| BlackRock, Inc. |
| 0.04% | 0.06% | #324 | $2.87B | 5.3M | $3.20B | 5.4M | -105,120-1.95% | Reduce |
| Avoro Capital Advisors LLC |
| 13.52% | 15.44% | #2 | $1.51B | 2.8M | $1.57B | 3.0M | -232,223-7.72% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.05% | 0.06% | #308 | $1.04B | 1.9M | $1.19B | 2.0M | -84,313-4.21% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.02% | 0.03% | #436 | $1.04B | 1.9M | $1.16B | 2.0M | -39,283-2.01% | Reduce |
| STATE STREET CORP |
| 0.03% | 0.04% | #373 | $1.03B | 1.9M | $1.09B | 1.8M | +54,101+2.93% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 1.28% | 1.66% | #37 | $925.8M | 1.7M | $1.06B | 1.8M | -78,280-4.38% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.13% | 0.25% | #173 | $747.2M | 1.4M | $1.34B | 2.3M | -885,222-39.10% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.03% | 0.05% | #387 | $538.9M | 996,598 | $729.9M | 1.2M | -236,431-19.17% | Reduce |
| Jupiter Topco LLC |
| 0.18% | — | #143 | $450.1M | 831,129 | $0 | 0 | +831,129 | New Buy |
| Caption Management, LLC |
| 1.9% | 3.99% | #24 | $408.6M | 754,133 | $682.9M | 1.2M | -397,512-34.52% | Reduce |
| CITADEL ADVISORS LLC |
| 0.05% | 0.07% | #311 | $405.3M | 747,992 | $413.8M | 697,843 | +50,149+7.19% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.03% | 0.06% | #378 | $383.6M | 707,879 | $511.4M | 862,496 | -154,617-17.93% | Reduce |
| NORGES BANK |
| 0.04% | 0.02% | #342 | $376.4M | 694,753 | $143.8M | 466,353 | +228,400+48.98% | Add |
| ASSETMARK, INC |
| 0.58% | 0.74% | #61 | $338.1M | 624,068 | $365.3M | 616,050 | +8,018+1.30% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| 0.1% | 0.22% | #204 | $294.6M | 546,002 | $486.4M | 826,226 | -280,224-33.92% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| 0.05% | 0.06% | #292 | $286.0M | 527,904 | $304.0M | 512,739 | +15,165+2.96% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.09% | 0.07% | #223 | $262.8M | 485,074 | $180.7M | 304,772 | +180,302+59.16% | Add |
| FMR LLC |
| 0.01% | 0.02% | #547 | $256.5M | 473,409 | $313.3M | 528,346 | -54,937-10.40% | Reduce |
| Invesco Ltd. |
| 0.02% | 0.05% | #454 | $256.3M | 473,109 | $360.7M | 608,367 | -135,258-22.23% | Reduce |
| BAILLIE GIFFORD & CO |
| 0.23% | 0.25% | #127 | $253.1M | 467,209 | $253.9M | 428,127 | +39,082+9.13% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 2.58% | 3.2% | #16 | $247.6M | 457,000 | $271.0M | 457,000 | 00.00% | Unchanged |
| MORGAN STANLEY |
| 0.01% | 0.01% | #528 | $236.6M | 436,699 | $184.0M | 438,804 | -2,105-0.48% | Reduce |
| Vestal Point Capital, LP |
| 5.51% | 1.24% | #4 | $235.7M | 435,000 | $44.5M | 75,000 | +360,000+480.00% | Add |
| NORTHERN TRUST CORP |
| 0.03% | 0.03% | #397 | $233.4M | 430,844 | $258.9M | 436,566 | -5,722-1.31% | Reduce |
| JANE STREET GROUP, LLC |
| 0.02% | 0.02% | #470 | $223.6M | 412,726 | $120.6M | 203,359 | +209,367+102.95% | Add |
| FRANKLIN RESOURCES INC |
| 0.04% | 0.04% | #341 | $184.4M | 340,275 | $164.8M | 277,983 | +62,292+22.41% | Add |
| Swedbank AB |
| 0.15% | 0.2% | #155 | $175.0M | 322,995 | $194.0M | 327,122 | -4,127-1.26% | Reduce |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.2% | 0.25% | #138 | $172.5M | 318,320 | $178.0M | 300,204 | +18,116+6.03% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.02% | 0.03% | #443 | $161.0M | 297,162 | $178.2M | 300,481 | -3,319-1.10% | Reduce |
| Bank of New York Mellon Corp |
| 0.03% | 0.04% | #406 | $159.5M | 294,413 | $195.2M | 329,148 | -34,735-10.55% | Reduce |
| Eversept Partners, LP |
| 8.09% | 8.26% | #3 | $155.9M | 287,668 | $156.7M | 264,271 | +23,397+8.85% | Add |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC |
| 0.22% | 0.33% | #128 | $154.3M | 284,783 | $203.8M | 343,659 | -58,876-17.13% | Reduce |
| JPMORGAN CHASE & CO |
| 0.01% | 0.01% | #593 | $151.0M | 275,358 | $171.6M | 291,621 | -16,263-5.58% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| 0.03% | 0.04% | #361 | $145.5M | 268,477 | $158.9M | 267,978 | +499+0.19% | Add |
| LSV ASSET MANAGEMENT |
| 0.26% | 0.51% | #104 | $145.4M | 268,370 | $236.4M | 398,665 | -130,295-32.68% | Reduce |
| Pictet Asset Management Holding SA |
| 0.14% | 0.19% | #167 | $145.2M | 267,852 | $183.3M | 309,220 | -41,368-13.38% | Reduce |
| CITIGROUP INC |
| 0.05% | 0.06% | #309 | $142.1M | 262,200 | $151.6M | 255,620 | +6,580+2.57% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.05% | 0.03% | #307 | $139.1M | 234,607 | $107.5M | 220,634 | +13,973+6.33% | Add |
| FIRST TRUST ADVISORS LP |
| 0.08% | 0.11% | #239 | $134.9M | 249,056 | $160.4M | 270,578 | -21,522-7.95% | Reduce |
| LORD, ABBETT & CO. LLC |
| 0.38% | 0.48% | #86 | $132.4M | 244,323 | $148.4M | 250,276 | -5,953-2.38% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.03% | #520 | $131.9M | 243,444 | $240.4M | 405,447 | -162,003-39.96% | Reduce |
| Qube Research & Technologies Ltd |
| 0.12% | 0.08% | #185 | $126.6M | 233,639 | $73.2M | 123,441 | +110,198+89.27% | Add |
| Soleus Capital Management, L.P. |
| 4.21% | 4.5% | #9 | $122.2M | 225,587 | $111.0M | 187,187 | +38,400+20.51% | Add |
| FULLER & THALER ASSET MANAGEMENT, INC. |
| 0.33% | 0.56% | #94 | $119.6M | 220,697 | $166.3M | 280,405 | -59,708-21.29% | Reduce |
| UBS Group AG |
| 0.02% | 0.02% | #498 | $119.5M | 220,616 | $140.4M | 236,729 | -16,113-6.81% | Reduce |
| Amundi |
| 0.03% | 0.02% | #386 | $118.7M | 219,094 | $87.5M | 147,599 | +71,495+48.44% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.02% | 0.03% | #442 | $118.2M | 218,164 | $122.9M | 207,309 | +10,855+5.24% | Add |
| Legal & General Group Plc |
| 0.02% | 0.03% | #430 | $112.2M | 207,093 | $110.8M | 186,794 | +20,299+10.87% | Add |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
| 1.04% | 1.54% | #43 | $112.1M | 206,808 | $149.8M | 252,702 | -45,894-18.16% | Reduce |
| Point72 Asset Management, L.P. |
| 0.12% | 0.13% | #181 | $109.0M | 201,159 | $101.2M | 170,703 | +30,456+17.84% | Add |
