| Darwin Global Management, Ltd. |
| 12.14% | 12.1% | #1 | $456.6M | 3.1M | $456.1M | 3.1M | +19,807+0.65% | Add |
| Paradigm Biocapital Advisors LP |
| 3.55% | 3.63% | #2 | $189.8M | 1.2M | $177.7M | 1.1M | +118,093+10.59% | Add |
| RTW INVESTMENTS, LP |
| 0.94% | 1.13% | #9 | $110.2M | 715,332 | $114.1M | 715,332 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| 0.03% | 0.04% | #31 | $76.2M | 494,564 | $90.9M | 570,088 | -75,524-13.25% | Reduce |
| MAVERICK CAPITAL LTD |
| 0.54% | — | #13 | $61.0M | 396,311 | $0 | 0 | +396,311 | New Buy |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.8% | 0.94% | #10 | $60.2M | 390,829 | $57.0M | 357,650 | +33,179+9.28% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.57% | 0.57% | #12 | $55.0M | 357,199 | $48.5M | 304,013 | +53,186+17.49% | Add |
| Holocene Advisors, LP |
| 0.09% | 0.19% | #21 | $38.7M | 251,035 | $78.8M | 494,495 | -243,460-49.23% | Reduce |
| Logos Global Management LP |
| 1.66% | — | #6 | $38.5M | 250,000 | $0 | 0 | +250,000 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #49 | $36.2M | 235,071 | $387,020 | 5,230 | +229,841+4,394.67% | Add |
| UBS Group AG |
| <0.01% | 0.02% | #43 | $34.6M | 224,989 | $122.5M | 768,359 | -543,370-70.72% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #46 | $28.7M | 186,168 | $320,156 | 2,008 | +184,160+9,171.31% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #48 | $25.6M | 166,188 | $16.8M | 105,509 | +60,679+57.51% | Add |
| Affinity Asset Advisors, LLC |
| 1.15% | 0.54% | #8 | $25.4M | 165,000 | $10.4M | 65,000 | +100,000+153.85% | Add |
| MPM BioImpact LLC |
| 1.29% | 1.08% | #7 | $21.1M | 137,208 | $14.0M | 88,045 | +49,163+55.84% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #55 | $19.2M | 124,783 | $602,365 | 3,778 | +121,005+3,202.89% | Add |
| Patient Square Capital LP |
| 2.62% | 3.3% | #3 | $16.9M | 110,000 | $18.6M | 116,684 | -6,684-5.73% | Reduce |
| Duquesne Family Office LLC |
| 0.31% | 0.5% | #16 | $16.3M | 106,100 | $16.9M | 106,100 | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | 0.01% | #52 | $16.3M | 105,859 | $44.9M | 281,805 | -175,946-62.44% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #58 | $10.1M | 65,801 | $1.9M | 12,222 | +53,579+438.38% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #45 | $8.8M | 57,125 | $5.2M | 32,525 | +24,600+75.63% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #36 | $8.6M | 55,763 | $8.3M | 52,000 | +3,763+7.24% | Add |
| Point72 Asset Management, L.P. |
| 0.01% | — | #38 | $7.9M | 51,186 | $0 | 0 | +51,186 | New Buy |
| Soleus Capital Management, L.P. |
| 0.27% | — | #17 | $7.8M | 50,524 | $0 | 0 | +50,524 | New Buy |
| Trexquant Investment LP |
| 0.04% | 0.02% | #25 | $7.6M | 49,516 | $2.4M | 15,072 | +34,444+228.53% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #44 | $5.9M | 38,100 | $0 | 0 | +38,100 | New Buy |
| PFM Health Sciences, LP |
| 0.46% | 0.86% | #14 | $5.4M | 34,803 | $9.5M | 59,432 | -24,629-41.44% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #63 | $5.1M | 33,181 | $448 | 3 | +33,178+1,105,933.33% | Add |
| Walleye Capital LLC |
| 0.02% | — | #34 | $4.9M | 31,721 | $0 | 0 | +31,721 | New Buy |
| Artia Global Partners LP |
| 0.71% | 0.8% | #11 | $3.8M | 24,989 | $4.0M | 24,989 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #65 | $3.5M | 22,640 | $1.7M | 10,427 | +12,213+117.13% | Add |
| BALANCE CAPITAL PARTNERS L.P. |
| 2.49% | 2.63% | #4 | $3.5M | 22,500 | $2.3M | 14,500 | +8,000+55.17% | Add |
| NATIONAL BANK OF CANADA /FI/ |
| <0.01% | — | #47 | $3.1M | 20,000 | $0 | 0 | +20,000 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #69 | $2.5M | 15,924 | $2.6M | 16,048 | -124-0.77% | Reduce |
| Verdad Advisers, LP |
| 2.03% | 2.48% | #5 | $2.1M | 13,758 | $2.2M | 13,813 | -55-0.40% | Reduce |
| ORBIMED ADVISORS LLC |
| 0.04% | — | #29 | $2.0M | 13,300 | $0 | 0 | +13,300 | New Buy |
| TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #51 | $2.0M | 13,010 | $5.3M | 33,410 | -20,400-61.06% | Reduce |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | — | #30 | $2.0M | 12,733 | $0 | 0 | +12,733 | New Buy |
| Qube Research & Technologies Ltd |
| <0.01% | — | #50 | $1.9M | 12,171 | $0 | 0 | +12,171 | New Buy |
| Lighthouse Investment Partners, LLC |
| 0.04% | — | #28 | $1.5M | 10,000 | $0 | 0 | +10,000 | New Buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #56 | $1.5M | 9,820 | $3.1M | 19,600 | -9,780-49.90% | Reduce |
| HighVista Strategies LLC |
| 0.34% | 0.35% | #15 | $1.5M | 9,554 | $1.3M | 8,033 | +1,521+18.93% | Add |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #53 | $1.4M | 8,785 | $2.7M | 16,981 | -8,196-48.27% | Reduce |
| BARCLAYS PLC |
| <0.01% | <0.01% | #64 | $1.1M | 6,822 | $1.1M | 6,822 | 00.00% | Unchanged |
| Capricorn Fund Managers Ltd |
| 0.08% | — | #23 | $985,504 | 6,400 | $0 | 0 | +6,400 | New Buy |
| Voleon Capital Management LP |
| 0.02% | 0.03% | #33 | $968,412 | 6,289 | $1.3M | 7,883 | -1,594-20.22% | Reduce |
| GSA CAPITAL PARTNERS LLP |
| 0.04% | 0.02% | #27 | $671,991 | 4,364 | $262,000 | 1,645 | +2,719+165.29% | Add |
| SmartHarvest Portfolios, LLC |
| 0.22% | 0.28% | #18 | $671,221 | 4,359 | $667,575 | 4,187 | +172+4.11% | Add |
| XTX Topco Ltd |
| 0.01% | 0.04% | #39 | $667,217 | 4,333 | $2.4M | 15,058 | -10,725-71.22% | Reduce |
| Mariner, LLC |
| <0.01% | — | #59 | $590,533 | 3,835 | $0 | 0 | +3,835 | New Buy |
