| TANG CAPITAL MANAGEMENT LLC |
| 1.79% | 4.51% | #3 | $39.4M | 18.0M | $88.8M | 16.8M | +1.2M+7.15% | Add |
| ORBIMED ADVISORS LLC |
| 0.63% | 1.6% | #10 | $33.3M | 15.2M | $80.5M | 15.2M | 00.00% | Unchanged |
| MONTANOVA CAPITAL, LLC |
| 0.56% | 1.93% | #12 | $30.9M | 14.1M | $75.7M | 14.3M | -206,220-1.44% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #114 | $24.7M | 11.3M | $50.3M | 9.5M | +1.8M+18.68% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #94 | $21.8M | 10.0M | $35.4M | 6.7M | +3.3M+48.67% | Add |
| Enavate Sciences GP, LLC |
| 4.94% | 11.72% | #1 | $17.1M | 7.8M | $41.2M | 7.8M | 00.00% | Unchanged |
| Vivo Capital, LLC |
| 1.55% | 4.2% | #5 | $17.0M | 7.8M | $50.5M | 9.5M | -1.8M-18.74% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #119 | $13.4M | 6.1M | $31.9M | 6.0M | +81,607+1.35% | Add |
| Palo Alto Investors LP |
| 1.87% | 1.23% | #2 | $12.8M | 5.8M | $8.0M | 1.5M | +4.3M+285.06% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #47 | $10.3M | 4.7M | $4.5M | 846,220 | +3.9M+456.98% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #108 | $8.4M | 3.8M | $18.9M | 3.6M | +249,419+6.99% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #113 | $8.3M | 3.8M | $5.7M | 1.1M | +2.7M+248.31% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #79 | $8.1M | 3.7M | $4.7M | 891,110 | +2.8M+316.33% | Add |
| Qube Research & Technologies Ltd |
| 0.01% | 0.02% | #34 | $8.1M | 3.7M | $13.5M | 2.6M | +1.1M+44.59% | Add |
| Blue Owl Capital Holdings LP |
| 1.16% | 4.18% | #7 | $7.9M | 3.6M | $15.6M | 2.9M | +682,551+23.20% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #93 | $7.7M | 3.5M | $10.6M | 2.0M | +1.5M+76.96% | Add |
| Rock Springs Capital Management LP |
| 0.38% | 1.03% | #13 | $7.7M | 3.5M | $17.5M | 3.3M | +219,621+6.64% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #54 | $7.7M | 3.5M | $1.1M | 200,428 | +3.3M+1,650.82% | Add |
| Birchview Capital, LP |
| 1.66% | 4.41% | #4 | $3.7M | 1.7M | $7.8M | 1.5M | +209,133+14.27% | Add |
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
| 0.31% | — | #15 | $3.1M | 1.4M | $0 | 0 | +1.4M | New Buy |
| Fisher Asset Management, LLC |
| <0.01% | <0.01% | #81 | $3.0M | 1.4M | $7.1M | 1.3M | +43,631+3.24% | Add |
| ROYCE & ASSOCIATES LP |
| 0.02% | 0.08% | #26 | $2.9M | 1.3M | $8.6M | 1.6M | -283,018-17.47% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #152 | $2.7M | 1.2M | $9.5M | 1.8M | -589,525-32.72% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | 0.07% | #43 | $2.6M | 1.2M | $44.9M | 8.5M | -7.3M-86.02% | Reduce |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | — | #51 | $2.5M | 1.2M | $0 | 0 | +1.2M | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #118 | $2.5M | 1.1M | $5.5M | 1.0M | +92,356+8.81% | Add |
| Atle Fund Management AB |
| 0.62% | 0.99% | #11 | $2.3M | 1.0M | $3.1M | 41,831 | +1.0M+2,406.74% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #101 | $2.2M | 1.0M | $1.5M | 290,972 | +719,590+247.31% | Add |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #58 | $2.2M | 1.0M | $265,569 | 50,202 | +957,305+1,906.91% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #107 | $2.2M | 1.0M | $5.3M | 998,140 | +2,798+0.28% | Add |
| Blackstone Inc. |
| 0.01% | 0.04% | #36 | $2.0M | 899,936 | $9.8M | 1.9M | -957,912-51.56% | Reduce |
| FIRST TRUST ADVISORS LP |
| <0.01% | — | #74 | $1.8M | 807,004 | $0 | 0 | +807,004 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #160 | $1.7M | 789,399 | $4.3M | 847,702 | -58,303-6.88% | Reduce |
| KVP Capital Advisors, LP |
| 1.24% | 1.98% | #6 | $1.7M | 771,000 | $2.6M | 500,000 | +271,000+54.20% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #164 | $1.6M | 735,186 | $654,333 | 186,952 | +548,234+293.25% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #103 | $1.6M | 713,907 | $3.2M | 598,238 | +115,669+19.33% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #133 | $1.6M | 712,763 | $12.7M | 2.4M | -1.7M-70.19% | Reduce |
| Burkehill Global Management, LP |
| 0.06% | 0.18% | #23 | $1.5M | 700,000 | $3.7M | 700,000 | 00.00% | Unchanged |
| Point72 Asset Management, L.P. |
| <0.01% | — | #64 | $1.5M | 686,577 | $0 | 0 | +686,577 | New Buy |
| ACUTA CAPITAL PARTNERS, LLC |
| 0.91% | 3.17% | #8 | $1.3M | 595,213 | $4.5M | 849,076 | -253,863-29.90% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #169 | $1.2M | 566,919 | $4.6M | 865,613 | -298,694-34.51% | Reduce |
| CM Management, LLC |
| 0.77% | — | #9 | $1.2M | 550,000 | $0 | 0 | +550,000 | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #127 | $1.2M | 541,178 | $2.3M | 439,784 | +101,394+23.06% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | 0.01% | #59 | $1.1M | 523,777 | $2.6M | 497,818 | +25,959+5.21% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #174 | $869,638 | 397,095 | $2.1M | 391,725 | +5,370+1.37% | Add |
| Artia Global Partners LP |
| 0.15% | — | #16 | $839,208 | 383,200 | $0 | 0 | +383,200 | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #144 | $829,324 | 378,687 | $1.9M | 360,125 | +18,562+5.15% | Add |
| ArrowMark Colorado Holdings LLC |
| 0.03% | 0.07% | #25 | $798,785 | 364,742 | $2.7M | 514,793 | -150,051-29.15% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #147 | $768,760 | 351,032 | $1.6M | 297,301 | +53,731+18.07% | Add |
| MARSHALL WACE, LLP |
| <0.01% | — | #99 | $733,364 | 334,869 | $0 | 0 | +334,869 | New Buy |
