| MPM BioImpact LLC |
| 10.81% | 8.39% | #2 | $177.2M | 9.7M | $108.7M | 7.6M | +2.1M+27.24% | Add |
| Lynx1 Capital Management LP |
| 32.16% | 20.13% | #1 | $163.2M | 9.0M | $127.4M | 9.0M | 00.00% | Unchanged |
| BVF INC/IL |
| 2.68% | 2.6% | #7 | $104.7M | 5.8M | $81.7M | 5.8M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #81 | $95.3M | 5.2M | $63.2M | 4.4M | +782,800+17.59% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #52 | $69.7M | 3.8M | $28.8M | 2.0M | +1.8M+88.50% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #73 | $66.8M | 3.7M | $36.2M | 2.5M | +1.1M+44.20% | Add |
| Kynam Capital Management, LP |
| 3.13% | 2.73% | #5 | $56.7M | 3.1M | $44.3M | 3.1M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #93 | $47.6M | 2.6M | $35.3M | 2.5M | +131,032+5.28% | Add |
| RTW INVESTMENTS, LP |
| 0.37% | 0.24% | #16 | $43.1M | 2.4M | $24.2M | 1.7M | +658,387+38.59% | Add |
| Siren, L.L.C. |
| 0.7% | 0.47% | #13 | $34.5M | 1.9M | $17.0M | 1.2M | +700,000+58.66% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #78 | $28.2M | 1.5M | $19.4M | 1.4M | +179,041+13.09% | Add |
| Blue Owl Capital Holdings LP |
| 4.08% | 7.29% | #3 | $28.0M | 1.5M | $27.1M | 1.9M | -370,000-19.37% | Reduce |
| Venrock Adviser, LLC |
| 0.76% | 0.73% | #11 | $25.1M | 1.4M | $19.6M | 1.4M | 00.00% | Unchanged |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.26% | 0.2% | #19 | $19.7M | 1.1M | $15.8M | 1.1M | -30,192-2.71% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #57 | $19.1M | 1.0M | $12.9M | 906,028 | +140,666+15.53% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #76 | $18.2M | 1.0M | $6.5M | 455,449 | +546,149+119.91% | Add |
| Affinity Asset Advisors, LLC |
| 0.72% | 0.57% | #12 | $15.9M | 875,760 | $11.1M | 781,260 | +94,500+12.10% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #111 | $13.5M | 738,741 | $7.9M | 552,553 | +186,188+33.70% | Add |
| BOONE CAPITAL MANAGEMENT LLC |
| 3% | — | #6 | $12.8M | 704,442 | $0 | 0 | +704,442 | New Buy |
| Elmind Capital, LP |
| 3.16% | 2.14% | #4 | $12.6M | 690,000 | $7.5M | 530,000 | +160,000+30.19% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #112 | $11.5M | 629,035 | $2.4M | 400,154 | +228,881+57.20% | Add |
| TWIN FOCUS CAPITAL PARTNERS, LLC |
| 1.1% | 0.97% | #8 | $10.8M | 595,489 | $8.5M | 595,489 | 00.00% | Unchanged |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #55 | $10.6M | 581,338 | $5.1M | 360,874 | +220,464+61.09% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #88 | $10.4M | 571,080 | $6.4M | 449,258 | +121,822+27.12% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #92 | $9.3M | 513,184 | $4.2M | 292,378 | +220,806+75.52% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #113 | $9.3M | 510,325 | $7.3M | 516,724 | -6,399-1.24% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #71 | $8.6M | 471,947 | $11.4M | 805,700 | -333,753-41.42% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #89 | $8.5M | 464,034 | $6.2M | 432,893 | +31,141+7.19% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.12% | — | #25 | $7.8M | 426,478 | $0 | 0 | +426,478 | New Buy |
| TCG Crossover Management, LLC |
| 0.18% | 0.17% | #21 | $7.4M | 406,786 | $5.8M | 406,786 | 00.00% | Unchanged |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #72 | $7.0M | 382,840 | $5.2M | 367,906 | +14,934+4.06% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #68 | $6.7M | 366,232 | $5.2M | 366,582 | -350-0.10% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #79 | $6.6M | 363,136 | $4.9M | 342,852 | +20,284+5.92% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #50 | $6.0M | 326,811 | $4.6M | 324,111 | +2,700+0.83% | Add |
| GREAT POINT PARTNERS LLC |
| 1.03% | 0.98% | #9 | $5.5M | 300,000 | $4.3M | 300,000 | 00.00% | Unchanged |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | 0.01% | #49 | $5.3M | 292,500 | $4.1M | 289,115 | +3,385+1.17% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #137 | $5.2M | 282,631 | $4.0M | 297,231 | -14,600-4.91% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | 0.01% | #56 | $5.0M | 272,581 | $7.4M | 522,047 | -249,466-47.79% | Reduce |
| Bleichroeder LP |
| 0.81% | 0.25% | #10 | $4.6M | 250,000 | $1.4M | 100,000 | +150,000+150.00% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #114 | $4.5M | 248,627 | $2.9M | 202,385 | +46,242+22.85% | Add |
| FMR LLC |
| <0.01% | <0.01% | #149 | $4.4M | 240,115 | $102,774 | 7,232 | +232,883+3,220.17% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | — | #53 | $4.3M | 238,000 | $0 | 0 | +238,000 | New Buy |
| Susquehanna Portfolio Strategies, LLC |
| 0.07% | 0.05% | #27 | $4.3M | 233,842 | $3.3M | 233,842 | 00.00% | Unchanged |
| PFM Health Sciences, LP |
| 0.3% | 0.29% | #18 | $3.5M | 192,442 | $3.2M | 227,406 | -34,964-15.38% | Reduce |
| MOORE CAPITAL MANAGEMENT, LP |
| 0.05% | 0.03% | #28 | $3.5M | 189,946 | $1.5M | 105,960 | +83,986+79.26% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #119 | $3.1M | 171,031 | $2.0M | 143,708 | +27,323+19.01% | Add |
| Squarepoint Ops LLC |
| <0.01% | — | #58 | $3.1M | 168,117 | $0 | 0 | +168,117 | New Buy |
| PRUDENTIAL FINANCIAL INC |
| <0.01% | <0.01% | #60 | $3.1M | 167,555 | $2.1M | 149,445 | +18,110+12.12% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #117 | $3.0M | 164,716 | $2.1M | 149,626 | +15,090+10.09% | Add |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #87 | $2.8M | 156,317 | $2.0M | 144,107 | +12,210+8.47% | Add |
