| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.04% | 0.03% | #16 | $124.6M | 8.3M | $102.6M | 6.9M | +1.5M+21.17% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.02% | 0.02% | #20 | $45.8M | 3.1M | $38.7M | 2.6M | +467,181+18.01% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #30 | $43.4M | 2.9M | $42.7M | 2.9M | +39,864+1.39% | Add |
| Longaeva Partners L.P. |
| 0.92% | 1.76% | #3 | $42.1M | 2.8M | $47.4M | 3.2M | -365,684-11.50% | Reduce |
| Sessa Capital IM, L.P. |
| 0.5% | 0.54% | #4 | $29.9M | 2.0M | $29.8M | 2.0M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #55 | $29.8M | 2.0M | $390,531 | 26,175 | +2.0M+7,527.47% | Add |
| NORGES BANK |
| <0.01% | — | #33 | $29.3M | 2.0M | $0 | 0 | +2.0M | New Buy |
| Rock Springs Capital Management LP |
| 1.11% | 0.93% | #1 | $22.7M | 1.5M | $15.7M | 1.1M | +465,000+44.08% | Add |
| ExodusPoint Capital Management, LP |
| 0.14% | 3.11% | #12 | $21.5M | 1.4M | $6.1M | 409,248 | +1.0M+251.15% | Add |
| FMR LLC |
| <0.01% | <0.01% | #49 | $16.2M | 1.1M | $20.4M | 1.4M | -284,311-20.83% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #48 | $14.3M | 956,024 | $3.7M | 245,931 | +710,093+288.74% | Add |
| Boston Partners |
| 0.01% | 0.01% | #22 | $13.5M | 902,359 | $12.5M | 845,003 | +57,356+6.79% | Add |
| J. Goldman & Co LP |
| 0.32% | — | #6 | $12.4M | 830,218 | $0 | 0 | +830,218 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #37 | $8.1M | 539,313 | $0 | 0 | +539,313 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #47 | $6.2M | 413,416 | $4.6M | 311,349 | +102,067+32.78% | Add |
| STATE STREET CORP |
| <0.01% | — | #68 | $6.0M | 403,289 | $0 | 0 | +403,289 | New Buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.01% | 0.02% | #25 | $5.6M | 375,000 | $11.2M | 750,000 | -375,000-50.00% | Reduce |
| FIRST TRUST ADVISORS LP |
| <0.01% | <0.01% | #32 | $5.5M | 366,268 | $1.5M | 99,149 | +267,119+269.41% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #80 | $4.8M | 323,325 | $0 | 0 | +323,325 | New Buy |
| READYSTATE ASSET MANAGEMENT LP |
| 0.24% | 0.21% | #8 | $4.7M | 315,000 | $4.7M | 315,000 | 00.00% | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | — | #28 | $4.5M | 300,000 | $0 | 0 | +300,000 | New Buy |
| Burkehill Global Management, LP |
| 0.16% | 0.22% | #11 | $4.5M | 300,000 | $4.5M | 300,000 | 00.00% | Unchanged |
| Neuberger Berman Group LLC |
| <0.01% | — | #34 | $4.0M | 264,672 | $0 | 0 | +264,672 | New Buy |
| TUDOR INVESTMENT CORP ET AL |
| 0.01% | <0.01% | #29 | $3.9M | 258,215 | $237,228 | 15,900 | +242,315+1,523.99% | Add |
| Alberta Investment Management Corp |
| 0.02% | 0.02% | #18 | $3.7M | 250,000 | $3.7M | 250,000 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #52 | $3.6M | 243,916 | $0 | 0 | +243,916 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #65 | $3.6M | 238,819 | $746,940 | 50,063 | +188,756+377.04% | Add |
| CHILTON INVESTMENT CO INC. |
| 0.08% | 0.02% | #13 | $3.5M | 232,299 | $828,060 | 55,500 | +176,799+318.56% | Add |
| NORTHERN TRUST CORP |
| <0.01% | — | #57 | $3.4M | 227,933 | $0 | 0 | +227,933 | New Buy |
| Parkman Healthcare Partners LLC |
| 0.35% | 0.49% | #5 | $3.4M | 226,446 | $4.7M | 317,324 | -90,878-28.64% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #61 | $3.3M | 219,810 | $821,406 | 55,054 | +164,756+299.26% | Add |
| Ghisallo Capital Management LLC |
| 0.02% | 0.02% | #19 | $3.0M | 200,000 | $3.7M | 250,000 | -50,000-20.00% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #75 | $2.9M | 193,047 | $0 | 0 | +193,047 | New Buy |
| Game Creek Capital, LP |
| 1.01% | 0.11% | #2 | $2.9M | 192,250 | $324,510 | 21,750 | +170,500+783.91% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #51 | $2.5M | 164,170 | $0 | 0 | +164,170 | New Buy |
| XTX Topco Ltd |
| 0.02% | 0.01% | #17 | $1.9M | 124,582 | $469,488 | 31,467 | +93,115+295.91% | Add |
| Freestone Grove Partners LP |
| 0.01% | — | #23 | $1.7M | 116,694 | $0 | 0 | +116,694 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #79 | $1.4M | 92,400 | $4.5M | 299,399 | -206,999-69.14% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #39 | $1.3M | 88,300 | $0 | 0 | +88,300 | New Buy |
| Waterfront Wealth Inc. |
| 0.19% | — | #10 | $1.2M | 79,703 | $0 | 0 | +79,703 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #83 | $1.1M | 71,080 | $0 | 0 | +71,080 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #69 | $1.1M | 70,798 | $0 | 0 | +70,798 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #81 | $1.0M | 68,624 | $4.6M | 305,899 | -237,275-77.57% | Reduce |
| Rhenman & Partners Asset Management AB |
| 0.08% | — | #14 | $822,250 | 55,000 | $0 | 0 | +55,000 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #76 | $799,825 | 53,500 | $0 | 0 | +53,500 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #56 | $606,835 | 40,591 | $242,674 | 16,265 | +24,326+149.56% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | — | #58 | $518,954 | 34,713 | $0 | 0 | +34,713 | New Buy |
| Engineers Gate Manager LP |
| 0.01% | — | #27 | $513,293 | 34,334 | $0 | 0 | +34,334 | New Buy |
| Magnetar Financial LLC |
| <0.01% | — | #31 | $512,875 | 34,306 | $0 | 0 | +34,306 | New Buy |
| CITIGROUP INC |
| <0.01% | <0.01% | #70 | $497,910 | 33,305 | $23,469 | 1,573 | +31,732+2,017.29% | Add |
