| Alpha Wave Global, LP |
| 1.57% | 10.54% | #5 | $97.8M | 3.7M | $83.4M | 3.7M | 00.00% | Unchanged |
| Commodore Capital LP |
| 4.28% | 3.54% | #3 | $71.9M | 2.7M | $61.2M | 2.7M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #61 | $56.0M | 2.1M | $15.0M | 666,188 | +1.5M+218.38% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.64% | 0.88% | #10 | $42.5M | 1.6M | $45.2M | 2.0M | -400,000-19.90% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.06% | 0.01% | #25 | $42.2M | 1.6M | $8.7M | 385,000 | +1.2M+315.58% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $36.7M | 1.4M | $27.1M | 1.2M | +182,452+15.12% | Add |
| Spruce Street Capital LP |
| 7.01% | 7% | #2 | $35.7M | 1.4M | $29.1M | 1.3M | +27,837+2.10% | Add |
| Vivo Capital, LLC |
| 2.91% | 1.94% | #4 | $31.9M | 1.2M | $23.3M | 1.0M | +173,307+16.74% | Add |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #34 | $26.7M | 1.0M | $24.8M | 1.1M | -88,567-8.04% | Reduce |
| ARMISTICE CAPITAL, LLC |
| 0.28% | 0.36% | #14 | $22.8M | 864,000 | $20.5M | 912,000 | -48,000-5.26% | Reduce |
| Affinity Asset Advisors, LLC |
| 1.01% | 0.58% | #8 | $22.4M | 850,000 | $11.2M | 500,000 | +350,000+70.00% | Add |
| Vestal Point Capital, LP |
| 0.48% | 1.3% | #12 | $20.7M | 785,000 | $46.4M | 2.1M | -1.3M-61.97% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #70 | $18.1M | 685,945 | $4.5M | 199,503 | +486,442+243.83% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #59 | $17.9M | 678,199 | $6.6M | 292,899 | +385,300+131.55% | Add |
| 72 Investment Holdings, LLC |
| 35.27% | 30.26% | #1 | $17.6M | 667,778 | $15.0M | 667,778 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #44 | $16.7M | 632,701 | $10.6M | 473,403 | +159,298+33.65% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #35 | $14.7M | 558,320 | $18.5M | 821,982 | -263,662-32.08% | Reduce |
| Point72 Asset Management, L.P. |
| 0.01% | 0.01% | #31 | $13.3M | 502,950 | $11.3M | 503,087 | -137-0.03% | Reduce |
| Venrock Adviser, LLC |
| 0.4% | 0.42% | #13 | $13.2M | 500,000 | $11.2M | 500,000 | 00.00% | Unchanged |
| Integral Health Asset Management, LLC |
| 0.52% | 0.54% | #11 | $13.2M | 500,000 | $11.2M | 500,000 | 00.00% | Unchanged |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.07% | 0.08% | #22 | $12.9M | 487,576 | $10.9M | 486,726 | +850+0.17% | Add |
| Parkman Healthcare Partners LLC |
| 1.16% | — | #6 | $11.3M | 429,035 | $0 | 0 | +429,035 | New Buy |
| Ikarian Capital, LLC |
| 1.14% | 0.94% | #7 | $10.7M | 407,338 | $11.6M | 515,000 | -107,662-20.91% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #60 | $9.5M | 358,279 | $8.3M | 371,208 | -12,929-3.48% | Reduce |
| ORBIMED ADVISORS LLC |
| 0.13% | 0.07% | #18 | $6.8M | 257,852 | $3.8M | 167,500 | +90,352+53.94% | Add |
| Schonfeld Strategic Advisors LLC |
| 0.02% | — | #27 | $6.8M | 257,631 | $0 | 0 | +257,631 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #69 | $6.2M | 236,830 | $2.4M | 104,717 | +132,113+126.16% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #36 | $6.0M | 225,503 | $4.0M | 176,347 | +49,156+27.87% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #52 | $5.6M | 211,257 | $3.7M | 165,272 | +45,985+27.82% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #56 | $5.0M | 190,996 | $299,524 | 13,324 | +177,672+1,333.47% | Add |
| Saturn V Capital Management LP |
| 0.69% | 0.36% | #9 | $4.8M | 182,829 | $2.0M | 88,999 | +93,830+105.43% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #79 | $4.8M | 181,101 | $0 | 0 | +181,101 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #41 | $3.9M | 147,299 | $4.9M | 216,099 | -68,800-31.84% | Reduce |
| Eversept Partners, LP |
| 0.18% | 0.15% | #17 | $3.4M | 128,286 | $2.8M | 125,168 | +3,118+2.49% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.04% | 0.04% | #26 | $2.8M | 106,234 | $3.1M | 139,304 | -33,070-23.74% | Reduce |
| ALKEON CAPITAL MANAGEMENT LLC |
| <0.01% | 0.01% | #40 | $2.7M | 102,101 | $5.1M | 227,101 | -125,000-55.04% | Reduce |
| STIFEL FINANCIAL CORP |
| <0.01% | <0.01% | #45 | $2.3M | 85,480 | $1.9M | 86,335 | -855-0.99% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #78 | $2.1M | 80,583 | $382,565 | 17,018 | +63,565+373.52% | Add |
| AWM Investment Company, Inc. |
| 0.18% | 0.42% | #16 | $2.1M | 80,000 | $3.8M | 170,000 | -90,000-52.94% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | — | #74 | $2.0M | 76,330 | $0 | 0 | +76,330 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #88 | $2.0M | 74,940 | $245,365 | 61,036 | +13,904+22.78% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #43 | $1.9M | 71,399 | $2.3M | 103,499 | -32,100-31.01% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #75 | $1.9M | 70,913 | $1.3M | 59,799 | +11,114+18.59% | Add |
| AdvisorShares Investments LLC |
| 0.23% | 0.17% | #15 | $1.9M | 70,748 | $922,197 | 41,023 | +29,725+72.46% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #85 | $1.8M | 69,298 | $14.3M | 637,598 | -568,300-89.13% | Reduce |
| Nuveen, LLC |
| <0.01% | — | #72 | $1.6M | 62,342 | $0 | 0 | +62,342 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #83 | $1.5M | 58,697 | $387,780 | 17,250 | +41,447+240.27% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #47 | $1.5M | 55,509 | $1.3M | 60,076 | -4,567-7.60% | Reduce |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.02% | 0.02% | #28 | $1.3M | 50,653 | $1.2M | 52,653 | -2,000-3.80% | Reduce |
| XTX Topco Ltd |
| 0.02% | 0.02% | #30 | $1.2M | 46,601 | $895,626 | 39,841 | +6,760+16.97% | Add |
