| Novo Holdings A/S |
| 7.7% | 6.07% | #5 | $132.1M | 3.7M | $74.9M | 3.7M | 00.00% | Unchanged |
| FCPM III SERVICES B.V. |
| 15.41% | 9.08% | #2 | $115.6M | 3.2M | $65.6M | 3.2M | 00.00% | Unchanged |
| T. Rowe Price Investment Management, Inc. |
| 0.07% | 0.04% | #20 | $99.7M | 2.8M | $57.0M | 2.8M | -20,209-0.72% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #32 | $69.8M | 1.9M | $40.6M | 2.0M | -46,561-2.33% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #33 | $51.0M | 1.4M | $2.3M | 112,708 | +1.3M+1,162.50% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #58 | $36.7M | 1.0M | $27.2M | 1.3M | -314,597-23.48% | Reduce |
| Nan Fung Group Holdings Ltd |
| 26.47% | 16.28% | #1 | $34.8M | 971,253 | $19.7M | 971,253 | 00.00% | Unchanged |
| 5AM Venture Management, LLC |
| 11.83% | 5.36% | #3 | $34.0M | 950,011 | $19.3M | 950,011 | 00.00% | Unchanged |
| Sanofi |
| 6.12% | 5.52% | #7 | $32.7M | 912,041 | $18.5M | 912,041 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #52 | $30.5M | 852,150 | $6.9M | 339,116 | +513,034+151.29% | Add |
| FMR LLC |
| <0.01% | <0.01% | #46 | $29.5M | 823,556 | $4.2M | 204,501 | +619,055+302.71% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #56 | $28.1M | 784,150 | $14.6M | 719,820 | +64,330+8.94% | Add |
| Blue Owl Capital Holdings LP |
| 3.81% | 5.49% | #8 | $26.2M | 729,929 | $20.5M | 1.0M | -276,000-27.44% | Reduce |
| Paradigm Biocapital Advisors LP |
| 0.46% | — | #12 | $24.6M | 685,852 | $0 | 0 | +685,852 | New Buy |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 7.12% | 4.44% | #6 | $21.9M | 611,446 | $12.4M | 611,447 | -1-0.00% | Reduce |
| Velan Capital Investment Management LP |
| 10.76% | 6.28% | #4 | $17.7M | 492,893 | $10.0M | 492,893 | 00.00% | Unchanged |
| Siren, L.L.C. |
| 0.33% | 0.25% | #13 | $16.1M | 450,000 | $9.1M | 450,000 | 00.00% | Unchanged |
| Capital World Investors |
| <0.01% | — | #39 | $14.9M | 415,730 | $0 | 0 | +415,730 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #54 | $14.4M | 402,051 | $9.8M | 481,201 | -79,150-16.45% | Reduce |
| BAKER BROS. ADVISORS LP |
| 0.07% | 0.04% | #19 | $13.1M | 364,705 | $7.4M | 364,705 | 00.00% | Unchanged |
| DAFNA Capital Management LLC |
| 1.17% | 0.79% | #10 | $6.1M | 171,006 | $3.5M | 171,006 | 00.00% | Unchanged |
| BNP Paribas Asset Management Holding S.A. |
| 0.01% | — | #31 | $6.1M | 170,862 | $0 | 0 | +170,862 | New Buy |
| Freestone Grove Partners LP |
| 0.04% | 0.05% | #23 | $6.1M | 168,912 | $6.4M | 313,957 | -145,045-46.20% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #55 | $4.9M | 136,818 | $3.3M | 161,146 | -24,328-15.10% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #42 | $4.6M | 128,841 | $0 | 0 | +128,841 | New Buy |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 2.84% | 2.79% | #9 | $4.5M | 125,432 | $3.9M | 192,139 | -66,707-34.72% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #50 | $4.4M | 123,135 | $2.7M | 131,231 | -8,096-6.17% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #57 | $4.4M | 122,028 | $4.8M | 236,512 | -114,484-48.41% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #60 | $4.2M | 116,652 | $3.0M | 146,172 | -29,520-20.20% | Reduce |
| STEMPOINT CAPITAL LP |
| 0.55% | 0.37% | #11 | $3.8M | 106,906 | $2.0M | 100,000 | +6,906+6.91% | Add |
| SEVEN GRAND MANAGERS, LLC |
| 0.14% | 0.14% | #15 | $3.6M | 100,000 | $2.0M | 100,000 | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #77 | $3.5M | 96,761 | $2.3M | 112,604 | -15,843-14.07% | Reduce |
| LAZARD ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #36 | $2.9M | 80,082 | $2.9M | 142,016 | -61,934-43.61% | Reduce |
| Burkehill Global Management, LP |
| 0.1% | 0.08% | #17 | $2.7M | 75,000 | $1.5M | 75,000 | 00.00% | Unchanged |
| Boxer Capital Management, LLC |
| 0.2% | — | #14 | $2.7M | 75,000 | $0 | 0 | +75,000 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #47 | $2.5M | 70,484 | $758,329 | 37,301 | +33,183+88.96% | Add |
| Trexquant Investment LP |
| 0.01% | — | #25 | $2.3M | 63,792 | $0 | 0 | +63,792 | New Buy |
| TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #41 | $2.0M | 54,526 | $971,123 | 47,768 | +6,758+14.15% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #80 | $2.0M | 54,464 | $383,607 | 18,869 | +35,595+188.64% | Add |
| HRT FINANCIAL LP |
| <0.01% | — | #37 | $1.9M | 51,983 | $0 | 0 | +51,983 | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #64 | $1.9M | 51,917 | $939,409 | 46,208 | +5,709+12.36% | Add |
| Jain Global LLC |
| 0.01% | — | #30 | $1.6M | 45,551 | $0 | 0 | +45,551 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | — | #73 | $1.5M | 42,751 | $0 | 0 | +42,751 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #85 | $1.4M | 38,304 | $0 | 0 | +38,304 | New Buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.02% | — | #24 | $1.3M | 35,000 | $0 | 0 | +35,000 | New Buy |
| Weiss Asset Management LP |
| 0.01% | — | #26 | $1.2M | 33,094 | $0 | 0 | +33,094 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #72 | $1.1M | 30,410 | $802,323 | 39,465 | -9,055-22.94% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.04% | 0.45% | #22 | $949,652 | 26,497 | $7.6M | 374,909 | -348,412-92.93% | Reduce |
| Jump Financial, LLC |
| 0.01% | — | #28 | $903,956 | 25,222 | $0 | 0 | +25,222 | New Buy |
| XTX Topco Ltd |
| 0.01% | <0.01% | #27 | $893,097 | 24,919 | $208,606 | 10,261 | +14,658+142.85% | Add |
