| Jupiter Topco LLC |
| 0.04% | — | #27 | $94.8M | 1.3M | $0 | 0 | +1.3M | New Buy |
| Cormorant Asset Management, LP |
| 3.21% | 3.88% | #3 | $63.2M | 900,000 | $77.3M | 1.1M | -159,331-15.04% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #52 | $48.2M | 686,184 | $45.4M | 621,933 | +64,251+10.33% | Add |
| Vivo Capital, LLC |
| 3.57% | 3.38% | #2 | $39.1M | 557,172 | $40.7M | 557,172 | 00.00% | Unchanged |
| Vestal Point Capital, LP |
| 0.89% | 1% | #10 | $38.3M | 545,000 | $35.9M | 492,319 | +52,681+10.70% | Add |
| BRAIDWELL LP |
| 1.26% | 1.31% | #9 | $34.0M | 483,822 | $39.4M | 539,708 | -55,886-10.35% | Reduce |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.18% | 0.23% | #20 | $30.4M | 433,377 | $31.6M | 432,515 | +862+0.20% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.03% | #29 | $24.2M | 345,053 | $21.7M | 297,158 | +47,895+16.12% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | 0.06% | #28 | $23.5M | 335,000 | $36.2M | 495,743 | -160,743-32.42% | Reduce |
| Point72 Asset Management, L.P. |
| 0.03% | — | #32 | $23.0M | 327,416 | $0 | 0 | +327,416 | New Buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.21% | 0.24% | #18 | $19.9M | 283,000 | $20.7M | 283,000 | 00.00% | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.16% | 0.2% | #21 | $18.6M | 265,000 | $19.3M | 265,000 | 00.00% | Unchanged |
| Parkman Healthcare Partners LLC |
| 1.47% | 0.3% | #6 | $14.4M | 205,053 | $2.9M | 40,098 | +164,955+411.38% | Add |
| MPM BioImpact LLC |
| 0.87% | 1.2% | #11 | $14.2M | 202,114 | $15.5M | 212,175 | -10,061-4.74% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #41 | $12.0M | 171,315 | $10.0M | 136,677 | +34,638+25.34% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #50 | $9.4M | 133,689 | $5.4M | 74,369 | +59,320+79.76% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.12% | 0.16% | #23 | $9.1M | 130,013 | $9.5M | 130,013 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #62 | $8.6M | 122,178 | $7.9M | 108,239 | +13,939+12.88% | Add |
| SEVEN GRAND MANAGERS, LLC |
| 0.34% | 0.59% | #16 | $8.4M | 120,000 | $8.8M | 120,000 | 00.00% | Unchanged |
| GREAT POINT PARTNERS LLC |
| 1.45% | 3.69% | #7 | $7.7M | 109,603 | $16.1M | 220,000 | -110,397-50.18% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #58 | $7.3M | 104,146 | $6.5M | 88,716 | +15,430+17.39% | Add |
| ORBIMED ADVISORS LLC |
| 0.12% | 0.06% | #22 | $6.5M | 93,000 | $2.9M | 40,000 | +53,000+132.50% | Add |
| ACUTA CAPITAL PARTNERS, LLC |
| 4.54% | 5.76% | #1 | $6.5M | 92,745 | $8.2M | 111,996 | -19,251-17.19% | Reduce |
| Ikarian Capital, LLC |
| 0.66% | 0.99% | #13 | $6.2M | 88,951 | $12.2M | 166,647 | -77,696-46.62% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #63 | $5.6M | 80,060 | $4.4M | 60,482 | +19,578+32.37% | Add |
| Sio Capital Management, LLC |
| 0.86% | 0.9% | #12 | $5.2M | 73,952 | $6.3M | 86,083 | -12,131-14.09% | Reduce |
| Trexquant Investment LP |
| 0.03% | <0.01% | #30 | $5.0M | 70,615 | $543,699 | 7,451 | +63,164+847.73% | Add |
| B Group, Inc. |
| 2.22% | 3.65% | #4 | $4.7M | 67,500 | $4.9M | 67,500 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #43 | $4.7M | 66,740 | $3.9M | 52,832 | +13,908+26.32% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | — | #55 | $4.7M | 66,533 | $0 | 0 | +66,533 | New Buy |
| Schonfeld Strategic Advisors LLC |
| 0.02% | 0.01% | #34 | $4.7M | 66,277 | $966,414 | 13,244 | +53,033+400.43% | Add |
| Walleye Capital LLC |
| 0.02% | 0.02% | #33 | $4.6M | 66,106 | $3.9M | 53,706 | +12,400+23.09% | Add |
| Woodline Partners LP |
| 0.01% | 0.01% | #36 | $3.2M | 45,668 | $3.3M | 45,668 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #59 | $3.0M | 42,466 | $2.7M | 37,378 | +5,088+13.61% | Add |
| Artia Global Partners LP |
| 0.5% | 0.56% | #14 | $2.7M | 38,407 | $2.8M | 38,407 | 00.00% | Unchanged |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #54 | $2.7M | 37,902 | $3.7M | 50,027 | -12,125-24.24% | Reduce |
| LOS ANGELES CAPITAL MANAGEMENT LLC |
| 0.01% | — | #37 | $2.5M | 35,747 | $0 | 0 | +35,747 | New Buy |
| KVP Capital Advisors, LP |
| 1.64% | 1.73% | #5 | $2.2M | 31,813 | $2.3M | 31,813 | 00.00% | Unchanged |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 1.35% | 0.69% | #8 | $2.1M | 30,456 | $971,304 | 13,311 | +17,145+128.80% | Add |
| ADAR1 Capital Management, LLC |
| 0.1% | 0.15% | #24 | $2.1M | 30,300 | $2.5M | 33,900 | -3,600-10.62% | Reduce |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.05% | #31 | $2.0M | 27,870 | $3.7M | 51,290 | -23,420-45.66% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #74 | $1.9M | 26,966 | $1.4M | 19,422 | +7,544+38.84% | Add |
| AdvisorShares Investments LLC |
| 0.21% | 0.17% | #19 | $1.7M | 24,274 | $920,371 | 12,613 | +11,661+92.45% | Add |
| Aquatic Capital Management LLC |
| 0.05% | <0.01% | #26 | $1.5M | 20,831 | $149,224 | 2,045 | +18,786+918.63% | Add |
| PLATINUM INVESTMENT MANAGEMENT LTD |
| 0.33% | 0.35% | #17 | $1.3M | 19,127 | $1.4M | 19,127 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | <0.01% | #80 | $1.3M | 18,599 | $11.7M | 192,866 | -174,267-90.36% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #67 | $1.3M | 18,032 | $1.1M | 15,318 | +2,714+17.72% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #61 | $1.2M | 16,889 | $607,767 | 8,329 | +8,560+102.77% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #71 | $1.1M | 15,536 | $969,042 | 13,280 | +2,256+16.99% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #66 | $1.0M | 14,902 | $967,045 | 13,253 | +1,649+12.44% | Add |
