| RTW INVESTMENTS, LP |
| 0.52% | 0.63% | #6 | $60.5M | 17.7M | $63.3M | 17.7M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #78 | $33.9M | 9.9M | $28.0M | 7.8M | +2.1M+26.67% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #59 | $19.9M | 5.8M | $16.8M | 4.7M | +1.1M+23.88% | Add |
| CITIGROUP INC |
| 0.01% | 0.01% | #29 | $16.6M | 4.9M | $18.3M | 5.1M | -242,157-4.74% | Reduce |
| MARSHALL WACE, LLP |
| 0.01% | 0.01% | #25 | $13.8M | 4.0M | $10.9M | 3.0M | +990,547+32.60% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #30 | $13.7M | 4.0M | $11.2M | 3.1M | +882,220+28.29% | Add |
| Newtyn Management, LLC |
| 1.71% | 1.21% | #1 | $13.7M | 4.0M | $11.3M | 3.2M | +834,100+26.35% | Add |
| MAVERICK CAPITAL LTD |
| 0.12% | 0.15% | #11 | $13.4M | 3.9M | $12.8M | 3.6M | +356,591+10.00% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #100 | $12.9M | 3.8M | $13.5M | 3.8M | +8,651+0.23% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | 0.01% | #33 | $11.6M | 3.4M | $11.0M | 3.1M | +316,232+10.30% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #61 | $10.2M | 3.0M | $6.7M | 1.9M | +1.1M+59.77% | Add |
| Monaco Asset Management SAM |
| 0.67% | 1.36% | #4 | $8.5M | 2.5M | $7.4M | 2.1M | +422,165+20.51% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #83 | $8.1M | 2.4M | $7.8M | 2.2M | +181,473+8.29% | Add |
| FEDERATED HERMES, INC. |
| 0.01% | 0.01% | #24 | $7.9M | 2.3M | $3.7M | 1.0M | +1.3M+125.08% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.02% | 0.01% | #17 | $6.8M | 2.0M | $1.5M | 416,533 | +1.6M+374.13% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #89 | $6.7M | 2.0M | $2.7M | 796,224 | +1.2M+149.73% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #113 | $6.2M | 1.8M | $16.1M | 4.5M | -2.7M-59.43% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #70 | $3.8M | 1.1M | $1.0M | 288,264 | +837,236+290.44% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #111 | $3.6M | 1.1M | $11.9M | 3.6M | -2.6M-70.87% | Reduce |
| Opaleye Management Inc. |
| 0.31% | 0.45% | #8 | $3.4M | 1.0M | $3.4M | 955,000 | +45,000+4.71% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #50 | $3.3M | 950,552 | $7.8M | 2.2M | -1.2M-56.19% | Reduce |
| Jump Financial, LLC |
| 0.02% | 0.02% | #18 | $3.0M | 867,900 | $1.7M | 476,478 | +391,422+82.15% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #34 | $2.7M | 792,974 | $2.3M | 637,174 | +155,800+24.45% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #92 | $2.6M | 749,073 | $2.6M | 724,392 | +24,681+3.41% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #96 | $2.5M | 735,090 | $2.3M | 640,840 | +94,250+14.71% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #117 | $2.5M | 734,584 | $2.3M | 630,125 | +104,459+16.58% | Add |
| Prosight Management, LP |
| 0.41% | 0.4% | #7 | $2.4M | 700,000 | $2.4M | 683,856 | +16,144+2.36% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #40 | $2.3M | 670,527 | $3.6M | 1.0M | -341,599-33.75% | Reduce |
| Qube Research & Technologies Ltd |
| <0.01% | — | #42 | $2.2M | 644,869 | $0 | 0 | +644,869 | New Buy |
| Woodline Partners LP |
| 0.01% | 0.01% | #27 | $2.2M | 641,222 | $2.3M | 641,222 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #82 | $2.0M | 592,844 | $2.1M | 590,750 | +2,094+0.35% | Add |
| FMR LLC |
| <0.01% | <0.01% | #140 | $1.7M | 488,299 | $1.7M | 462,630 | +25,669+5.55% | Add |
| IEQ CAPITAL, LLC |
| 0.01% | 0.01% | #26 | $1.5M | 440,255 | $1.4M | 381,839 | +58,416+15.30% | Add |
| ADAR1 Capital Management, LLC |
| 0.07% | 0.09% | #13 | $1.5M | 435,500 | $1.5M | 432,500 | +3,000+0.69% | Add |
| Aberdeen Group plc |
| <0.01% | <0.01% | #46 | $1.4M | 397,727 | $2.4M | 664,821 | -267,094-40.18% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #73 | $1.3M | 387,065 | $963,757 | 269,206 | +117,859+43.78% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #129 | $1.3M | 383,316 | $1.2M | 347,543 | +35,773+10.29% | Add |
| LOS ANGELES CAPITAL MANAGEMENT LLC |
| <0.01% | — | #31 | $1.2M | 348,093 | $0 | 0 | +348,093 | New Buy |
| Susquehanna Portfolio Strategies, LLC |
| 0.02% | 0.01% | #20 | $1.1M | 332,106 | $933,696 | 260,809 | +71,297+27.34% | Add |
| LPL Financial LLC |
| <0.01% | <0.01% | #103 | $1.1M | 321,836 | $558,788 | 156,086 | +165,750+106.19% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #62 | $1.1M | 315,761 | $3.9M | 1.1M | -781,862-71.23% | Reduce |
| BIT Capital GmbH |
| 0.03% | — | #16 | $1.0M | 298,000 | $0 | 0 | +298,000 | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #112 | $940,531 | 275,009 | $46,533 | 12,998 | +262,011+2,015.78% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #122 | $888,548 | 259,809 | $858,636 | 239,842 | +19,967+8.33% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #143 | $845,544 | 247,235 | $2.0M | 553,639 | -306,404-55.34% | Reduce |
| Privium Fund Management B.V. |
| 0.15% | 0.18% | #9 | $834,979 | 244,146 | $866,883 | 242,146 | +2,000+0.83% | Add |
| Hennion & Walsh Asset Management, Inc. |
| 0.02% | 0.03% | #19 | $769,250 | 224,927 | $1.0M | 287,815 | -62,888-21.85% | Reduce |
| M28 Capital Management LP |
| 1.53% | 1.4% | #2 | $721,179 | 210,871 | $754,918 | 210,871 | 00.00% | Unchanged |
| ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #107 | $700,427 | 195,650 | $475,851 | 135,570 | +60,080+44.32% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #135 | $689,616 | 201,642 | $4.6M | 1.3M | -1.1M-84.47% | Reduce |
