| Samsara BioCapital, LLC |
| 4.44% | 3.36% | #1 | $54.0M | 1.7M | $34.6M | 1.7M | 00.00% | Unchanged |
| Casdin Capital, LLC |
| 2.43% | 2.17% | #4 | $48.6M | 1.5M | $28.6M | 1.4M | +125,000+8.80% | Add |
| Redmile Group, LLC |
| 2.98% | 1.95% | #3 | $44.4M | 1.4M | $29.4M | 1.5M | -47,400-3.25% | Reduce |
| RTW INVESTMENTS, LP |
| 0.37% | 0.27% | #9 | $42.8M | 1.4M | $27.5M | 1.4M | 00.00% | Unchanged |
| EcoR1 Capital, LLC |
| 1.94% | 1.09% | #6 | $40.0M | 1.3M | $25.6M | 1.3M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #45 | $33.3M | 1.1M | $20.3M | 1.0M | +52,913+5.26% | Add |
| BAKER BROS. ADVISORS LP |
| 0.16% | 0.11% | #11 | $31.2M | 991,691 | $20.0M | 991,691 | 00.00% | Unchanged |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.02% | #15 | $25.7M | 818,706 | $14.5M | 718,389 | +100,317+13.96% | Add |
| Trails Edge Capital Partners, LP |
| 3.57% | 3.62% | #2 | $22.5M | 714,885 | $15.8M | 782,787 | -67,902-8.67% | Reduce |
| TORONTO DOMINION BANK |
| 0.02% | 0.02% | #17 | $21.4M | 681,337 | $13.7M | 681,337 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $16.9M | 536,525 | $10.4M | 514,727 | +21,798+4.23% | Add |
| JENNISON ASSOCIATES LLC |
| 0.01% | 0.01% | #25 | $16.3M | 518,582 | $10.6M | 527,685 | -9,103-1.73% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #34 | $13.7M | 435,682 | $8.3M | 413,231 | +22,451+5.43% | Add |
| GREAT POINT PARTNERS LLC |
| 2.09% | 2.32% | #5 | $11.1M | 352,180 | $10.1M | 500,000 | -147,820-29.56% | Reduce |
| ArrowMark Colorado Holdings LLC |
| 0.45% | 0.28% | #8 | $10.8M | 342,453 | $10.6M | 524,796 | -182,343-34.75% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #49 | $9.3M | 295,561 | $7.7M | 382,647 | -87,086-22.76% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #46 | $9.2M | 293,182 | $5.6M | 279,003 | +14,179+5.08% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #63 | $7.1M | 224,322 | $6.3M | 313,005 | -88,683-28.33% | Reduce |
| FRANKLIN RESOURCES INC |
| <0.01% | — | #35 | $6.4M | 204,280 | $0 | 0 | +204,280 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #58 | $6.0M | 191,724 | $7.4M | 426,576 | -234,852-55.06% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #42 | $5.4M | 171,289 | $3.7M | 185,679 | -14,390-7.75% | Reduce |
| BLAIR WILLIAM & CO/IL |
| 0.01% | 0.01% | #22 | $4.6M | 146,905 | $3.4M | 168,218 | -21,313-12.67% | Reduce |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.03% | <0.01% | #16 | $4.5M | 143,528 | $660,542 | 32,765 | +110,763+338.05% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | — | #28 | $4.5M | 141,920 | $0 | 0 | +141,920 | New Buy |
| MOORE CAPITAL MANAGEMENT, LP |
| 0.07% | — | #14 | $4.5M | 141,636 | $0 | 0 | +141,636 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #61 | $3.4M | 107,100 | $3.1M | 153,200 | -46,100-30.09% | Reduce |
| Rock Springs Capital Management LP |
| 0.16% | 0.12% | #10 | $3.4M | 106,750 | $2.1M | 104,339 | +2,411+2.31% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #37 | $3.4M | 106,660 | $2.1M | 106,255 | +405+0.38% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #52 | $3.3M | 103,641 | $2.0M | 97,621 | +6,020+6.17% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #60 | $3.2M | 101,276 | $2.2M | 107,714 | -6,438-5.98% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #76 | $3.0M | 95,601 | $1.3M | 65,080 | +30,521+46.90% | Add |
| DAFNA Capital Management LLC |
| 0.53% | 0.26% | #7 | $2.8M | 89,032 | $1.1M | 56,635 | +32,397+57.20% | Add |
| Woodline Partners LP |
| 0.01% | 0.01% | #26 | $2.6M | 83,835 | $1.7M | 83,835 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #44 | $2.3M | 74,262 | $1.4M | 69,712 | +4,550+6.53% | Add |
| Trexquant Investment LP |
| 0.01% | — | #20 | $2.3M | 73,762 | $0 | 0 | +73,762 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #79 | $2.0M | 61,882 | $1.3M | 64,922 | -3,040-4.68% | Reduce |
| XTX Topco Ltd |
| 0.02% | 0.01% | #18 | $1.7M | 55,424 | $553,009 | 27,431 | +27,993+102.05% | Add |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
| <0.01% | <0.01% | #36 | $1.7M | 52,300 | $1.0M | 52,300 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #48 | $1.3M | 42,734 | $4.1M | 204,809 | -162,075-79.13% | Reduce |
| Raiffeisen Bank International AG |
| 0.01% | 0.01% | #21 | $1.1M | 34,000 | $829,900 | 43,000 | -9,000-20.93% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #75 | $1.0M | 32,742 | $605,969 | 30,058 | +2,684+8.93% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #68 | $1.0M | 32,628 | $230,126 | 11,415 | +21,213+185.83% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #69 | $987,310 | 31,393 | $0 | 0 | +31,393 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #72 | $903,897 | 28,741 | $525,032 | 26,043 | +2,698+10.36% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #64 | $875,065 | 27,824 | $508,234 | 25,210 | +2,614+10.37% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #86 | $820,499 | 26,089 | $491,904 | 24,400 | +1,689+6.92% | Add |
| Quadrature Capital Ltd |
| 0.01% | — | #27 | $764,864 | 24,320 | $0 | 0 | +24,320 | New Buy |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #57 | $733,729 | 23,330 | $373,766 | 18,540 | +4,790+25.84% | Add |
| Seven Fleet Capital Management LP |
| 0.11% | — | #12 | $693,787 | 22,060 | $0 | 0 | +22,060 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #39 | $641,737 | 20,405 | $874,944 | 43,400 | -22,995-52.98% | Reduce |
