| Bratton Capital Management, L.P. |
| 100% | 100% | #1 | $40.8M | 9.8M | $40.7M | 9.8M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #97 | $33.6M | 8.1M | $31.2M | 7.5M | +560,302+7.46% | Add |
| RTW INVESTMENTS, LP |
| 0.26% | 0.31% | #10 | $30.9M | 7.4M | $30.8M | 7.4M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #104 | $19.1M | 4.6M | $0 | 0 | +4.6M | New Buy |
| FEDERATED HERMES, INC. |
| 0.02% | 0.02% | #24 | $12.9M | 3.1M | $12.2M | 2.9M | +172,222+5.86% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #109 | $12.2M | 2.9M | $10.6M | 2.5M | +381,829+15.00% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #94 | $10.9M | 2.6M | $10.0M | 2.4M | +214,697+8.92% | Add |
| Samsara BioCapital, LLC |
| 0.85% | 1.01% | #5 | $10.4M | 2.5M | $10.4M | 2.5M | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #101 | $6.9M | 1.7M | $10.0M | 2.4M | -736,627-30.63% | Reduce |
| Sio Capital Management, LLC |
| 1.02% | 1.14% | #4 | $6.2M | 1.5M | $8.0M | 1.9M | -436,712-22.71% | Reduce |
| Propel Bio Management, LLC |
| 3.14% | 1.86% | #2 | $6.0M | 1.4M | $3.0M | 710,988 | +731,409+102.87% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #100 | $5.8M | 1.4M | $6.7M | 1.6M | -227,930-14.11% | Reduce |
| WASATCH ADVISORS LP |
| 0.04% | 0.02% | #17 | $5.8M | 1.4M | $3.6M | 878,316 | +507,527+57.78% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #48 | $5.3M | 1.3M | $4.7M | 1.1M | +141,823+12.45% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #75 | $5.1M | 1.2M | $1.1M | 253,465 | +961,760+379.44% | Add |
| Janney Montgomery Scott LLC |
| 0.01% | 0.01% | #30 | $4.6M | 1.1M | $4.5M | 1.1M | +17,050+1.57% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #89 | $4.5M | 1.1M | $4.3M | 1.0M | +54,393+5.26% | Add |
| COMMONWEALTH EQUITY SERVICES, LLC |
| 0.01% | 0.01% | #38 | $4.4M | 1.0M | $4.5M | 1.1M | -36,505-3.37% | Reduce |
| BARCLAYS PLC |
| <0.01% | <0.01% | #86 | $4.1M | 996,665 | $3.3M | 799,163 | +197,502+24.71% | Add |
| Blue Owl Capital Holdings LP |
| 0.57% | 1.5% | #7 | $3.9M | 942,932 | $5.6M | 1.3M | -405,000-30.05% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #105 | $3.5M | 831,151 | $3.0M | 732,504 | +98,647+13.47% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #71 | $3.3M | 794,688 | $3.4M | 809,007 | -14,319-1.77% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | 0.02% | #47 | $3.1M | 744,536 | $12.0M | 2.9M | -2.2M-74.33% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #138 | $3.1M | 734,245 | $0 | 0 | +734,245 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #111 | $3.0M | 710,897 | $4.2M | 1.0M | -308,606-30.27% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #136 | $2.7M | 658,617 | $7.9M | 1.4M | -751,492-53.29% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #92 | $2.7M | 651,211 | $0 | 0 | +651,211 | New Buy |
| DAFNA Capital Management LLC |
| 0.51% | 0.35% | #8 | $2.7M | 645,915 | $1.5M | 368,415 | +277,500+75.32% | Add |
| Everstar Asset Management, LLC |
| 1.05% | 1.22% | #3 | $2.5M | 611,943 | $2.3M | 553,181 | +58,762+10.62% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #134 | $2.0M | 482,290 | $4.6M | 1.1M | -633,260-56.77% | Reduce |
| AWM Investment Company, Inc. |
| 0.17% | 0.12% | #14 | $2.0M | 475,400 | $1.1M | 270,400 | +205,000+75.81% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #133 | $1.9M | 468,569 | $1.9M | 466,767 | +1,802+0.39% | Add |
| Bracebridge Capital, LLC |
| 0.37% | 0.18% | #9 | $1.9M | 459,216 | $1.9M | 459,216 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #122 | $1.9M | 458,414 | $1.9M | 464,207 | -5,793-1.25% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #64 | $1.7M | 416,248 | $0 | 0 | +416,248 | New Buy |
| STIFEL FINANCIAL CORP |
| <0.01% | <0.01% | #74 | $1.5M | 361,903 | $1.5M | 359,903 | +2,000+0.56% | Add |
| Man Group plc |
| <0.01% | — | #65 | $1.5M | 351,700 | $0 | 0 | +351,700 | New Buy |
| HRT FINANCIAL LP |
| <0.01% | — | #61 | $1.4M | 344,811 | $0 | 0 | +344,811 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #132 | $1.3M | 306,394 | $1.1M | 267,419 | +38,975+14.57% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #126 | $1.3M | 301,647 | $1.2M | 290,060 | +11,587+3.99% | Add |
| GROUP ONE TRADING LLC |
| <0.01% | 0.01% | #70 | $1.2M | 300,400 | $2.7M | 659,800 | -359,400-54.47% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #81 | $1.2M | 285,659 | $76,007 | 18,315 | +267,344+1,459.70% | Add |
| Walleye Capital LLC |
| <0.01% | 0.01% | #44 | $1.2M | 282,568 | $2.4M | 584,977 | -302,409-51.70% | Reduce |
| Simplify Asset Management Inc. |
| 0.02% | 0.01% | #25 | $1.2M | 278,723 | $972,258 | 234,279 | +44,444+18.97% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #129 | $1.1M | 275,544 | $1.1M | 255,184 | +20,360+7.98% | Add |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #84 | $1.1M | 260,481 | $938,577 | 226,163 | +34,318+15.17% | Add |
| Rosalind Advisors, Inc. |
| 0.25% | 0.42% | #11 | $1.0M | 250,000 | $1.0M | 250,000 | 00.00% | Unchanged |
| Latash Investments, LLC |
| 0.74% | 0.78% | #6 | $1.0M | 243,134 | $1.0M | 243,134 | 00.00% | Unchanged |
| Hudson Bay Capital Management LP |
| <0.01% | <0.01% | #60 | $973,440 | 234,000 | $971,100 | 234,000 | 00.00% | Unchanged |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #93 | $957,632 | 230,200 | $786,010 | 189,400 | +40,800+21.54% | Add |
