| BlackRock, Inc. |
| <0.01% | <0.01% | #80 | $99.8M | 4.1M | $104.0M | 3.4M | +723,246+21.14% | Add |
| TANG CAPITAL MANAGEMENT LLC |
| 4.48% | 5.25% | #1 | $98.7M | 4.1M | $103.4M | 3.4M | +700,000+20.59% | Add |
| MONTANOVA CAPITAL, LLC |
| 1.8% | 2.97% | #7 | $98.6M | 4.1M | $116.1M | 3.8M | +274,184+7.18% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #67 | $81.8M | 3.4M | $66.3M | 2.2M | +1.2M+55.70% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #91 | $55.3M | 2.3M | $61.6M | 2.0M | +269,942+13.31% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #64 | $38.6M | 1.6M | $41.5M | 1.4M | +237,087+17.37% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #59 | $38.0M | 1.6M | $27.7M | 911,976 | +666,155+73.05% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #54 | $37.2M | 1.5M | $43.8M | 1.4M | +106,212+7.38% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.32% | 0.49% | #14 | $36.3M | 1.5M | $45.8M | 1.5M | 00.00% | Unchanged |
| PERCEPTIVE ADVISORS LLC |
| 0.54% | — | #11 | $36.1M | 1.5M | $0 | 0 | +1.5M | New Buy |
| Boxer Capital Management, LLC |
| 2.53% | 2.35% | #4 | $33.6M | 1.4M | $17.9M | 590,000 | +805,156+136.47% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #74 | $33.0M | 1.4M | $34.0M | 1.1M | +253,960+22.71% | Add |
| FMR LLC |
| <0.01% | <0.01% | #90 | $27.4M | 1.1M | $23.5M | 772,649 | +365,081+47.25% | Add |
| Ikarian Capital, LLC |
| 2.44% | 2.17% | #5 | $23.0M | 954,215 | $26.7M | 878,015 | +76,200+8.68% | Add |
| DIADEMA PARTNERS LP |
| 2.57% | 5.34% | #3 | $20.8M | 863,700 | $31.4M | 1.0M | -167,851-16.27% | Reduce |
| Soleus Capital Management, L.P. |
| 0.63% | — | #10 | $18.3M | 761,737 | $0 | 0 | +761,737 | New Buy |
| Caption Management, LLC |
| 0.08% | 0.07% | #25 | $17.2M | 714,100 | $11.2M | 368,600 | +345,500+93.73% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #96 | $16.5M | 684,515 | $4.0M | 551,694 | +132,821+24.08% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #100 | $15.3M | 636,087 | $11.5M | 379,214 | +256,873+67.74% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #71 | $14.9M | 619,661 | $11.3M | 371,984 | +247,677+66.58% | Add |
| DG Capital Management, LLC |
| 3.1% | 3.65% | #2 | $14.7M | 611,595 | $11.9M | 392,096 | +219,499+55.98% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #81 | $12.1M | 503,532 | $12.7M | 417,543 | +85,989+20.59% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.01% | #41 | $11.7M | 486,836 | $9.0M | 297,123 | +189,713+63.85% | Add |
| J. Goldman & Co LP |
| 0.29% | 0.5% | #15 | $11.2M | 463,321 | $17.1M | 561,522 | -98,201-17.49% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #51 | $10.6M | 438,746 | $9.6M | 315,000 | +123,746+39.28% | Add |
| Jones Hill Capital LP |
| 2.15% | 5.93% | #6 | $10.1M | 420,751 | $27.6M | 909,207 | -488,456-53.72% | Reduce |
| MERCER GLOBAL ADVISORS INC /ADV |
| 0.01% | 0.02% | #43 | $9.7M | 402,731 | $12.3M | 402,999 | -268-0.07% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $9.7M | 402,226 | $10.8M | 356,354 | +45,872+12.87% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #70 | $9.0M | 372,539 | $9.7M | 320,098 | +52,441+16.38% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #111 | $8.7M | 362,501 | $9.5M | 343,613 | +18,888+5.50% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.1% | 0.11% | #22 | $7.2M | 298,862 | $8.3M | 274,445 | +24,417+8.90% | Add |
| GROUP ONE TRADING LLC |
| 0.01% | 0.01% | #47 | $6.6M | 272,609 | $3.9M | 127,138 | +145,471+114.42% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #115 | $6.0M | 251,235 | $12.6M | 415,483 | -164,248-39.53% | Reduce |
| RTW INVESTMENTS, LP |
| 0.05% | 0.08% | #27 | $6.0M | 250,000 | $7.6M | 250,000 | 00.00% | Unchanged |
| Nuveen, LLC |
| <0.01% | <0.01% | #84 | $5.7M | 236,612 | $5.0M | 162,906 | +73,706+45.24% | Add |
| Palo Alto Investors LP |
| 0.81% | 1.07% | #8 | $5.5M | 229,763 | $7.0M | 229,763 | 00.00% | Unchanged |
| HBK Sorce Advisory LLC |
| 0.1% | 0.12% | #20 | $5.4M | 223,076 | $6.2M | 204,837 | +18,239+8.90% | Add |
| Trexquant Investment LP |
| 0.03% | 0.05% | #32 | $4.8M | 197,793 | $6.8M | 222,413 | -24,620-11.07% | Reduce |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #86 | $4.7M | 196,856 | $6.0M | 196,300 | +556+0.28% | Add |
| MOODY ALDRICH PARTNERS LLC |
| 0.77% | 1.24% | #9 | $4.3M | 177,754 | $6.9M | 226,028 | -48,274-21.36% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #101 | $3.9M | 161,767 | $4.0M | 130,730 | +31,037+23.74% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #110 | $3.9M | 160,938 | $3.8M | 126,023 | +34,915+27.71% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #124 | $3.4M | 140,500 | $30.7M | 1.0M | -870,781-86.11% | Reduce |
| LMR Partners LLP |
| 0.01% | 0.01% | #42 | $3.4M | 140,300 | $2.6M | 87,100 | +53,200+61.08% | Add |
| Woodline Partners LP |
| 0.01% | 0.02% | #44 | $3.3M | 138,773 | $4.2M | 137,655 | +1,118+0.81% | Add |
| PFM Health Sciences, LP |
| 0.25% | 0.34% | #16 | $2.9M | 122,221 | $3.8M | 123,831 | -1,610-1.30% | Reduce |
| Pier Capital, LLC |
| 0.36% | 0.22% | #13 | $2.7M | 111,908 | $1.3M | 44,401 | +67,507+152.04% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #95 | $2.7M | 111,623 | $1.3M | 42,536 | +69,087+162.42% | Add |
| Jefferies Financial Group Inc. |
| 0.02% | 0.02% | #37 | $2.5M | 105,755 | $3.2M | 104,361 | +1,394+1.34% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #113 | $2.4M | 100,246 | $3.3M | 108,604 | -8,358-7.70% | Reduce |
