| BlackRock, Inc. |
| <0.01% | <0.01% | #87 | $63.2M | 7.6M | $72.1M | 6.8M | +811,539+11.94% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #72 | $34.3M | 4.1M | $41.2M | 3.9M | +233,771+6.01% | Add |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.02% | #38 | $29.0M | 3.5M | $38.6M | 3.6M | -143,414-3.94% | Reduce |
| PFIZER INC |
| 16.24% | 14.63% | #1 | $27.7M | 3.5M | $34.9M | 3.5M | 00.00% | Unchanged |
| ARMISTICE CAPITAL, LLC |
| 0.28% | 0.37% | #7 | $23.2M | 2.8M | $21.0M | 2.0M | +818,000+41.35% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #107 | $22.6M | 2.7M | $28.5M | 2.7M | +24,801+0.92% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.02% | 0.02% | #37 | $21.4M | 2.6M | $19.4M | 1.8M | +741,333+40.46% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #104 | $18.3M | 2.2M | $19.4M | 1.8M | +368,400+20.15% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #92 | $13.9M | 1.7M | $16.5M | 1.6M | +110,158+7.07% | Add |
| Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #42 | $13.2M | 1.6M | $12.7M | 1.2M | +390,641+32.51% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.04% | 0.06% | #25 | $11.7M | 1.4M | $15.3M | 1.4M | -28,878-2.00% | Reduce |
| FEDERATED HERMES, INC. |
| 0.02% | 0.02% | #35 | $11.3M | 1.4M | $12.1M | 1.1M | +215,317+18.88% | Add |
| Nextech Invest Ltd. |
| 0.43% | 0.4% | #5 | $9.0M | 1.1M | $5.7M | 539,394 | +583,319+108.14% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #46 | $7.1M | 848,382 | $10.1M | 949,874 | -101,492-10.68% | Reduce |
| Hillsdale Investment Management Inc. |
| 0.14% | — | #9 | $6.2M | 750,900 | $0 | 0 | +750,900 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #100 | $6.1M | 728,147 | $4.5M | 427,093 | +301,054+70.49% | Add |
| TCG Crossover Management, LLC |
| 0.14% | 0.72% | #10 | $5.9M | 707,098 | $25.3M | 2.4M | -1.7M-70.38% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #96 | $5.6M | 677,773 | $13.0M | 1.2M | -549,715-44.78% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #85 | $5.4M | 654,909 | $5.1M | 485,764 | +169,145+34.82% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #111 | $5.3M | 640,811 | $8.0M | 756,875 | -116,064-15.33% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #102 | $5.1M | 615,296 | $5.5M | 520,955 | +94,341+18.11% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #68 | $5.0M | 601,873 | $3.0M | 285,118 | +316,755+111.10% | Add |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.09% | 0.12% | #13 | $4.9M | 589,238 | $5.9M | 552,641 | +36,597+6.62% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #69 | $4.8M | 574,011 | $6.1M | 576,352 | -2,341-0.41% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #99 | $4.5M | 542,174 | $5.6M | 525,174 | +17,000+3.24% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #133 | $4.2M | 502,755 | $14.2M | 1.7M | -1.2M-69.75% | Reduce |
| NORDEA INVESTMENT MANAGEMENT AB |
| <0.01% | <0.01% | #56 | $4.0M | 476,196 | $5.1M | 474,503 | +1,693+0.36% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #109 | $3.7M | 444,674 | $723,407 | 68,246 | +376,428+551.58% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #91 | $3.6M | 427,224 | $4.4M | 412,596 | +14,628+3.55% | Add |
| ALGERT GLOBAL LLC |
| 0.04% | 0.03% | #26 | $3.5M | 426,415 | $1.9M | 179,496 | +246,919+137.56% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #98 | $3.0M | 366,423 | $2.3M | 216,788 | +149,635+69.02% | Add |
| FMR LLC |
| <0.01% | <0.01% | #153 | $3.0M | 365,206 | $935,259 | 88,232 | +276,974+313.92% | Add |
| Brummer Multi-Strategy AB |
| 11.43% | 12.58% | #2 | $3.0M | 285,076 | $3.0M | 285,076 | 00.00% | Unchanged |
| Ikarian Capital, LLC |
| 0.32% | 0.31% | #6 | $3.0M | 358,257 | $3.8M | 358,257 | 00.00% | Unchanged |
| Nantahala Capital Management, LLC |
| 0.08% | 0.12% | #15 | $2.5M | 300,000 | $3.2M | 300,000 | 00.00% | Unchanged |
| Jump Financial, LLC |
| 0.02% | 0.02% | #33 | $2.5M | 296,168 | $1.4M | 133,818 | +162,350+121.32% | Add |
| Arbiter Partners Capital Management LLC |
| 1.29% | — | #4 | $2.4M | 294,594 | $0 | 0 | +294,594 | New Buy |
| Man Group plc |
| <0.01% | <0.01% | #54 | $2.1M | 256,104 | $964,271 | 90,969 | +165,135+181.53% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #120 | $2.1M | 254,997 | $2.5M | 236,714 | +18,283+7.72% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #152 | $2.1M | 252,939 | $1.2M | 116,800 | +136,139+116.56% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #145 | $2.1M | 247,920 | $3.4M | 316,654 | -68,734-21.71% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #63 | $1.8M | 215,345 | $0 | 0 | +215,345 | New Buy |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #66 | $1.7M | 201,822 | $248,676 | 23,460 | +178,362+760.28% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #122 | $1.5M | 185,347 | $2.0M | 185,495 | -148-0.08% | Reduce |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| <0.01% | <0.01% | #65 | $1.5M | 180,000 | $1.9M | 180,000 | 00.00% | Unchanged |
| Rangeley Capital, LLC |
| 1.39% | 2.31% | #3 | $1.5M | 175,590 | $2.4M | 223,990 | -48,400-21.61% | Reduce |
| Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #60 | $1.4M | 167,056 | $1.4M | 131,974 | +35,082+26.58% | Add |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #83 | $1.4M | 166,222 | $1.5M | 137,185 | +29,037+21.17% | Add |
| Susquehanna Portfolio Strategies, LLC |
| 0.02% | 0.05% | #32 | $1.3M | 158,285 | $3.2M | 301,245 | -142,960-47.46% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #118 | $1.3M | 151,167 | $1.6M | 147,522 | +3,645+2.47% | Add |
