| BlackRock, Inc. |
| <0.01% | <0.01% | #73 | $76.6M | 6.4M | $48.5M | 5.8M | +614,632+10.63% | Add |
| Redmile Group, LLC |
| 3.51% | 2.42% | #2 | $52.3M | 4.4M | $36.6M | 4.4M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #77 | $35.6M | 3.0M | $22.9M | 2.7M | +239,688+8.78% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #64 | $26.2M | 2.2M | $27.1M | 3.5M | -1.3M-36.44% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #95 | $25.2M | 2.1M | $16.8M | 2.0M | +100,411+5.00% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #69 | $23.4M | 2.0M | $16.4M | 1.7M | +248,969+14.61% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #63 | $17.0M | 1.4M | $15.4M | 1.8M | -418,010-22.72% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| 0.01% | <0.01% | #38 | $16.5M | 1.4M | $8.8M | 1.1M | +326,646+31.06% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #85 | $16.2M | 1.4M | $8.5M | 1.0M | +336,653+33.04% | Add |
| MARSHALL WACE, LLP |
| 0.01% | — | #23 | $15.4M | 1.3M | $0 | 0 | +1.3M | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #83 | $14.9M | 1.2M | $9.5M | 1.1M | +103,798+9.13% | Add |
| Integral Health Asset Management, LLC |
| 0.38% | 0.6% | #8 | $9.6M | 800,000 | $12.6M | 1.5M | -700,000-46.67% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #79 | $9.0M | 754,923 | $312,574 | 37,300 | +717,623+1,923.92% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #53 | $8.9M | 740,026 | $4.9M | 582,016 | +158,010+27.15% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #58 | $8.8M | 731,586 | $8.5M | 1.0M | -278,795-27.59% | Reduce |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #46 | $8.5M | 712,814 | $2.4M | 286,001 | +426,813+149.23% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #36 | $8.0M | 669,808 | $4.6M | 554,892 | +114,916+20.71% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #93 | $6.9M | 579,412 | $3.5M | 414,984 | +164,428+39.62% | Add |
| STIFEL FINANCIAL CORP |
| 0.01% | <0.01% | #40 | $6.7M | 560,727 | $3.3M | 392,769 | +167,958+42.76% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #101 | $6.2M | 518,545 | $2.7M | 324,860 | +193,685+59.62% | Add |
| 22NW, LP |
| 5.64% | 3.25% | #1 | $5.9M | 492,759 | $4.1M | 492,759 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #56 | $5.8M | 480,762 | $2.4M | 285,174 | +195,588+68.59% | Add |
| Pale Fire Capital SE |
| 0.39% | 0.36% | #7 | $5.6M | 466,209 | $4.1M | 493,726 | -27,517-5.57% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #90 | $5.1M | 421,839 | $3.3M | 393,640 | +28,199+7.16% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #89 | $4.7M | 396,450 | $3.3M | 390,601 | +5,849+1.50% | Add |
| LAZARD ASSET MANAGEMENT LLC |
| 0.01% | — | #32 | $4.4M | 370,375 | $0 | 0 | +370,375 | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #124 | $4.1M | 342,858 | $2.6M | 311,268 | +31,590+10.15% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #81 | $4.0M | 337,159 | $2.6M | 312,064 | +25,095+8.04% | Add |
| Quantinno Capital Management LP |
| <0.01% | <0.01% | #44 | $3.6M | 300,127 | $368,309 | 43,951 | +256,176+582.87% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #110 | $3.5M | 293,293 | $1.6M | 187,848 | +105,445+56.13% | Add |
| GSK plc |
| 0.54% | 0.38% | #5 | $3.3M | 271,456 | $2.3M | 271,456 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #45 | $3.1M | 256,686 | $2.6M | 305,286 | -48,600-15.92% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #103 | $3.0M | 249,947 | $2.2M | 257,463 | -7,516-2.92% | Reduce |
| Jump Financial, LLC |
| 0.02% | 0.02% | #16 | $2.9M | 239,700 | $1.9M | 220,789 | +18,911+8.57% | Add |
| Hudson Bay Capital Management LP |
| 0.01% | 0.01% | #31 | $2.7M | 225,000 | $1.5M | 180,000 | +45,000+25.00% | Add |
| ArchPoint Investors |
| 0.56% | 0.44% | #4 | $2.7M | 222,278 | $1.9M | 222,278 | 00.00% | Unchanged |
| Corient Private Wealth LLC |
| <0.01% | — | #55 | $2.6M | 217,661 | $0 | 0 | +217,661 | New Buy |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #86 | $2.5M | 207,835 | $1.7M | 196,971 | +10,864+5.52% | Add |
| Walleye Capital LLC |
| 0.01% | — | #29 | $2.4M | 203,726 | $0 | 0 | +203,726 | New Buy |
| Y-Intercept (Hong Kong) Ltd |
| 0.04% | 0.04% | #13 | $2.2M | 181,471 | $2.3M | 275,021 | -93,550-34.02% | Reduce |
| Assenagon Asset Management S.A. |
| <0.01% | 0.01% | #50 | $2.0M | 169,279 | $8.2M | 980,611 | -811,332-82.74% | Reduce |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| <0.01% | <0.01% | #49 | $1.8M | 149,000 | $1.2M | 149,000 | 00.00% | Unchanged |
| IEQ CAPITAL, LLC |
| 0.01% | 0.01% | #30 | $1.7M | 141,469 | $1.2M | 139,639 | +1,830+1.31% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #112 | $1.6M | 134,194 | $1.2M | 140,219 | -6,025-4.30% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #133 | $1.6M | 133,851 | $1.3M | 158,829 | -24,978-15.73% | Reduce |
| CITIGROUP INC |
| <0.01% | <0.01% | #97 | $1.5M | 123,022 | $1.0M | 124,650 | -1,628-1.31% | Reduce |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #74 | $1.5M | 121,359 | $950,504 | 113,425 | +7,934+6.99% | Add |
| Susquehanna Portfolio Strategies, LLC |
| 0.02% | 0.02% | #17 | $1.4M | 119,471 | $1.6M | 186,601 | -67,130-35.98% | Reduce |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| <0.01% | <0.01% | #100 | $1.3M | 107,719 | $938,652 | 112,011 | -4,292-3.83% | Reduce |
| XTX Topco Ltd |
| 0.02% | <0.01% | #21 | $1.3M | 107,300 | $284,082 | 33,900 | +73,400+216.52% | Add |
