| Sands Capital Alternatives, LLC |
| 18.68% | — | #2 | $114.6M | 4.2M | $0 | 0 | +4.2M | New Buy |
| Samsara BioCapital, LLC |
| 5.52% | — | #3 | $67.2M | 2.5M | $0 | 0 | +2.5M | New Buy |
| T. Rowe Price Investment Management, Inc. |
| 0.04% | — | #18 | $59.7M | 2.2M | $0 | 0 | +2.2M | New Buy |
| ARK Investment Management LLC |
| 0.24% | — | #9 | $37.2M | 1.4M | $0 | 0 | +1.4M | New Buy |
| BRAIDWELL LP |
| 1.09% | — | #5 | $29.4M | 1.1M | $0 | 0 | +1.1M | New Buy |
| ALLIANCEBERNSTEIN L.P. |
| 0.01% | — | #30 | $27.2M | 1.0M | $0 | 0 | +1.0M | New Buy |
| Hillhouse Capital Advisors, Ltd. |
| 3.11% | — | #4 | $25.9M | 956,462 | $0 | 0 | +956,462 | New Buy |
| BlackRock, Inc. |
| <0.01% | — | #53 | $24.7M | 911,445 | $0 | 0 | +911,445 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | — | #31 | $23.5M | 865,764 | $0 | 0 | +865,764 | New Buy |
| FMR LLC |
| <0.01% | — | #43 | $22.5M | 829,424 | $0 | 0 | +829,424 | New Buy |
| PURA VIDA INVESTMENTS, LLC |
| 55.35% | — | #1 | $20.5M | 755,909 | $0 | 0 | +755,909 | New Buy |
| EMERALD ADVISERS, LLC |
| 0.41% | — | #7 | $17.5M | 647,183 | $0 | 0 | +647,183 | New Buy |
| Artisan Partners Limited Partnership |
| 0.03% | — | #20 | $16.6M | 613,744 | $0 | 0 | +613,744 | New Buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.17% | — | #10 | $16.3M | 600,000 | $0 | 0 | +600,000 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #58 | $12.6M | 463,385 | $0 | 0 | +463,385 | New Buy |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.06% | — | #17 | $12.5M | 462,900 | $0 | 0 | +462,900 | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #39 | $12.4M | 457,974 | $0 | 0 | +457,974 | New Buy |
| EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.4% | — | #8 | $11.4M | 422,127 | $0 | 0 | +422,127 | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #38 | $11.3M | 418,965 | $0 | 0 | +418,965 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #50 | $8.9M | 330,134 | $0 | 0 | +330,134 | New Buy |
| Woodline Partners LP |
| 0.02% | — | #22 | $6.6M | 243,320 | $0 | 0 | +243,320 | New Buy |
| NEW YORK STATE COMMON RETIREMENT FUND |
| 0.01% | — | #37 | $5.4M | 200,758 | $0 | 0 | +200,758 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | — | #48 | $4.9M | 180,000 | $0 | 0 | +180,000 | New Buy |
| LORD, ABBETT & CO. LLC |
| 0.01% | — | #28 | $4.8M | 177,552 | $0 | 0 | +177,552 | New Buy |
| LMR Partners LLP |
| 0.02% | — | #26 | $4.7M | 175,000 | $0 | 0 | +175,000 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | — | #52 | $4.3M | 160,029 | $0 | 0 | +160,029 | New Buy |
| Ghisallo Capital Management LLC |
| 0.02% | — | #21 | $4.1M | 150,000 | $0 | 0 | +150,000 | New Buy |
| SEVEN GRAND MANAGERS, LLC |
| 0.16% | — | #12 | $4.1M | 150,000 | $0 | 0 | +150,000 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #51 | $3.1M | 114,956 | $0 | 0 | +114,956 | New Buy |
| Alyeska Investment Group, L.P. |
| 0.01% | — | #32 | $3.1M | 113,396 | $0 | 0 | +113,396 | New Buy |
| Avidity Partners Management LP |
| 0.48% | — | #6 | $3.0M | 110,000 | $0 | 0 | +110,000 | New Buy |
| ExodusPoint Capital Management, LP |
| 0.02% | — | #27 | $2.7M | 100,691 | $0 | 0 | +100,691 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | — | #54 | $2.7M | 100,120 | $0 | 0 | +100,120 | New Buy |
| Burkehill Global Management, LP |
| 0.1% | — | #13 | $2.7M | 100,000 | $0 | 0 | +100,000 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | — | #67 | $2.6M | 92,665 | $0 | 0 | +92,665 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #69 | $2.5M | 91,085 | $0 | 0 | +91,085 | New Buy |
| UBS Group AG |
| <0.01% | — | #56 | $2.4M | 86,751 | $0 | 0 | +86,751 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #49 | $2.2M | 82,282 | $0 | 0 | +82,282 | New Buy |
| Freestone Grove Partners LP |
| 0.01% | — | #29 | $1.6M | 60,000 | $0 | 0 | +60,000 | New Buy |
| SOROS FUND MANAGEMENT LLC |
| 0.02% | — | #23 | $1.6M | 60,000 | $0 | 0 | +60,000 | New Buy |
| IEQ CAPITAL, LLC |
| 0.01% | — | #34 | $1.6M | 58,795 | $0 | 0 | +58,795 | New Buy |
| Sumitomo Mitsui Trust Group, Inc. |
| <0.01% | — | #44 | $1.5M | 56,452 | $0 | 0 | +56,452 | New Buy |
| Amova Asset Management Americas, Inc. |
| 0.02% | — | #24 | $1.5M | 55,800 | $0 | 0 | +55,800 | New Buy |
| Bellevue Group AG |
| 0.03% | — | #19 | $1.5M | 55,738 | $0 | 0 | +55,738 | New Buy |
| Point72 Asset Management, L.P. |
| <0.01% | — | #40 | $1.4M | 51,800 | $0 | 0 | +51,800 | New Buy |
| Shay Capital LLC |
| 0.07% | — | #15 | $1.1M | 40,000 | $0 | 0 | +40,000 | New Buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
| 0.06% | — | #16 | $941,161 | 34,742 | $0 | 0 | +34,742 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #66 | $880,804 | 32,514 | $0 | 0 | +32,514 | New Buy |
| TD ASSET MANAGEMENT INC |
| <0.01% | — | #47 | $724,441 | 26,742 | $0 | 0 | +26,742 | New Buy |
| Weiss Asset Management LP |
| 0.01% | — | #36 | $677,250 | 25,000 | $0 | 0 | +25,000 | New Buy |
