| RA CAPITAL MANAGEMENT, L.P. |
| 1.04% | 0.71% | #8 | $120.2M | 12.0M | $67.2M | 9.3M | +2.7M+28.87% | Add |
| PERCEPTIVE ADVISORS LLC |
| 1.79% | 1.68% | #5 | $118.9M | 11.9M | $85.7M | 11.9M | 00.00% | Unchanged |
| Bain Capital Life Sciences Investors, LLC |
| 5.83% | 6.37% | #2 | $98.0M | 9.8M | $70.6M | 9.8M | 00.00% | Unchanged |
| Siren, L.L.C. |
| 1.55% | 1.53% | #6 | $76.8M | 7.7M | $55.4M | 7.7M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #74 | $69.3M | 6.9M | $35.7M | 5.0M | +2.0M+39.85% | Add |
| FMR LLC |
| <0.01% | <0.01% | #52 | $68.7M | 6.9M | $26.0M | 3.6M | +3.3M+90.66% | Add |
| ARMISTICE CAPITAL, LLC |
| 0.52% | 0.41% | #10 | $42.7M | 4.3M | $23.0M | 3.2M | +1.1M+33.69% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #66 | $41.7M | 4.2M | $8.1M | 1.1M | +3.0M+270.98% | Add |
| Jupiter Topco LLC |
| 0.02% | — | #36 | $40.4M | 4.0M | $0 | 0 | +4.0M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #75 | $40.1M | 4.0M | $0 | 0 | +4.0M | New Buy |
| RTW INVESTMENTS, LP |
| 0.33% | — | #14 | $38.9M | 3.9M | $0 | 0 | +3.9M | New Buy |
| Deep Track Capital, LP |
| 0.52% | 0.42% | #11 | $35.6M | 3.6M | $25.7M | 3.6M | 00.00% | Unchanged |
| FRANKLIN RESOURCES INC |
| 0.01% | <0.01% | #42 | $34.4M | 3.4M | $15.8M | 2.2M | +1.2M+56.90% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #51 | $28.4M | 2.8M | $19.1M | 2.6M | +197,822+7.47% | Add |
| Alyeska Investment Group, L.P. |
| 0.06% | 0.05% | #23 | $22.8M | 2.3M | $16.4M | 2.3M | +359+0.02% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #47 | $22.2M | 2.2M | $17.6M | 2.4M | -213,066-8.74% | Reduce |
| Vestal Point Capital, LP |
| 0.5% | 1.01% | #13 | $21.6M | 2.2M | $36.0M | 5.0M | -2.8M-56.80% | Reduce |
| Redmile Group, LLC |
| 1.31% | 0.96% | #7 | $19.5M | 1.9M | $14.5M | 2.0M | -63,200-3.14% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #73 | $19.4M | 1.9M | $9.3M | 1.3M | +644,840+49.76% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #62 | $17.0M | 1.7M | $6.7M | 935,535 | +767,382+82.03% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.02% | #31 | $15.0M | 1.5M | $12.6M | 1.8M | -250,000-14.23% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #54 | $12.6M | 1.3M | $6.9M | 956,135 | +310,155+32.44% | Add |
| BLAIR WILLIAM & CO/IL |
| 0.02% | 0.01% | #34 | $7.6M | 756,277 | $4.7M | 651,216 | +105,061+16.13% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #97 | $7.5M | 748,589 | $0 | 0 | +748,589 | New Buy |
| Woodline Partners LP |
| 0.02% | 0.01% | #32 | $6.7M | 674,076 | $3.6M | 495,076 | +179,000+36.16% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.69% | — | #9 | $6.7M | 668,450 | $0 | 0 | +668,450 | New Buy |
| Birchview Capital, LP |
| 3.01% | 2.57% | #3 | $6.7M | 666,196 | $4.5M | 625,980 | +40,216+6.42% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #79 | $6.0M | 603,647 | $3.0M | 418,199 | +185,448+44.34% | Add |
| MOORE CAPITAL MANAGEMENT, LP |
| 0.09% | 0.05% | #20 | $6.0M | 603,472 | $2.3M | 324,749 | +278,723+85.83% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #98 | $5.2M | 524,102 | $2.8M | 386,793 | +137,309+35.50% | Add |
| Monashee Investment Management LLC |
| 8.38% | 5.56% | #1 | $5.0M | 500,000 | $10.2M | 1.4M | -920,295-64.80% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #71 | $4.9M | 494,730 | $0 | 0 | +494,730 | New Buy |
| Point72 Asset Management, L.P. |
| <0.01% | 0.02% | #45 | $4.5M | 448,008 | $14.8M | 2.1M | -1.6M-78.15% | Reduce |
| STEMPOINT CAPITAL LP |
| 0.51% | 0.26% | #12 | $3.6M | 358,780 | $1.4M | 195,403 | +163,377+83.61% | Add |
| Boxer Capital Management, LLC |
| 0.23% | 0.28% | #16 | $3.0M | 300,000 | $2.2M | 300,000 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #119 | $2.7M | 281,673 | $1.8M | 276,412 | +5,261+1.90% | Add |
| Ally Bridge Group (NY) LLC |
| 2.26% | 4.46% | #4 | $2.6M | 255,959 | $5.5M | 766,974 | -511,015-66.63% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #123 | $2.5M | 255,195 | $1.6M | 257,846 | -2,651-1.03% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #99 | $2.4M | 244,401 | $1.2M | 160,730 | +83,671+52.06% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #93 | $2.4M | 243,154 | $993,194 | 137,944 | +105,210+76.27% | Add |
| J. Goldman & Co LP |
| 0.06% | 0.06% | #22 | $2.4M | 242,164 | $2.0M | 284,467 | -42,303-14.87% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #81 | $2.4M | 241,642 | $2.9M | 400,292 | -158,650-39.63% | Reduce |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #72 | $2.2M | 222,789 | $924,106 | 128,348 | +94,441+73.58% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #115 | $2.1M | 213,737 | $4.1M | 575,831 | -362,094-62.88% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #105 | $1.9M | 188,347 | $712,642 | 98,978 | +89,369+90.29% | Add |
| ALGERT GLOBAL LLC |
| 0.02% | 0.01% | #28 | $1.9M | 187,419 | $523,000 | 72,654 | +114,765+157.96% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #100 | $1.9M | 185,365 | $1.2M | 161,278 | +24,087+14.94% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #56 | $1.8M | 178,253 | $1.2M | 178,253 | 00.00% | Unchanged |
| APIS CAPITAL ADVISORS, LLC |
| 0.16% | 0.18% | #18 | $1.6M | 160,000 | $1.2M | 160,000 | 00.00% | Unchanged |
| Soleus Capital Management, L.P. |
| 0.05% | — | #24 | $1.5M | 150,000 | $0 | 0 | +150,000 | New Buy |
