| Merck & Co., Inc. |
| 35.75% | 25.6% | #1 | $188.2M | 14.0M | $89.5M | 14.0M | 00.00% | Unchanged |
| ARK Investment Management LLC |
| 0.72% | 0.39% | #14 | $110.8M | 8.3M | $50.6M | 7.9M | +327,227+4.12% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #73 | $94.9M | 7.1M | $34.3M | 5.4M | +1.7M+31.40% | Add |
| Lightspeed Management Company, L.L.C. |
| 3.4% | 5.26% | #3 | $81.8M | 6.1M | $52.0M | 8.2M | -2.1M-25.23% | Reduce |
| AMERIPRISE FINANCIAL INC |
| 0.02% | 0.01% | #38 | $81.6M | 6.1M | $48.4M | 7.6M | -1.5M-19.84% | Reduce |
| Deep Track Capital, LP |
| 0.78% | 0.31% | #13 | $53.6M | 4.0M | $19.1M | 3.0M | +1.0M+33.33% | Add |
| Aberdeen Group plc |
| 0.07% | 0.04% | #26 | $50.2M | 3.7M | $22.2M | 3.5M | +258,982+7.42% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #89 | $40.3M | 3.0M | $18.3M | 2.9M | +141,687+4.94% | Add |
| Casdin Capital, LLC |
| 1.71% | 0.77% | #5 | $34.2M | 2.6M | $10.2M | 1.6M | +950,000+59.38% | Add |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.56% | 0.29% | #17 | $31.7M | 2.4M | $13.9M | 2.2M | +180,710+8.28% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #77 | $24.4M | 1.8M | $8.3M | 1.3M | +524,790+40.44% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #70 | $24.4M | 1.8M | $709,019 | 111,306 | +1.7M+1,535.62% | Add |
| AIGH Capital Management LLC |
| 1.45% | 2.52% | #7 | $23.0M | 1.7M | $18.5M | 2.9M | -1.2M-40.86% | Reduce |
| Blue Water Life Science Advisors, LP |
| 14.15% | 8.56% | #2 | $22.5M | 1.7M | $10.7M | 1.7M | 00.00% | Unchanged |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #53 | $20.1M | 1.5M | $6.8M | 1.1M | +430,735+40.40% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #94 | $19.9M | 1.5M | $7.2M | 1.1M | +352,907+31.12% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #87 | $17.0M | 1.3M | $2.2M | 342,055 | +928,891+271.56% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #74 | $15.7M | 1.2M | $4.7M | 737,132 | +432,699+58.70% | Add |
| HRT FINANCIAL LP |
| 0.02% | <0.01% | #35 | $12.5M | 930,816 | $1.3M | 208,891 | +721,925+345.60% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #83 | $11.6M | 865,741 | $226,135 | 35,500 | +830,241+2,338.71% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #58 | $10.1M | 753,004 | $2.2M | 343,520 | +409,484+119.20% | Add |
| STEMPOINT CAPITAL LP |
| 1.33% | — | #8 | $9.3M | 717,783 | $0 | 0 | +717,783 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #105 | $8.8M | 659,834 | $3.6M | 560,539 | +99,295+17.71% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #82 | $8.5M | 632,803 | $2.6M | 405,800 | +227,003+55.94% | Add |
| Trexquant Investment LP |
| 0.05% | — | #28 | $8.0M | 600,216 | $0 | 0 | +600,216 | New Buy |
| HOWLAND CAPITAL MANAGEMENT LLC |
| 0.27% | 0.14% | #21 | $7.4M | 555,641 | $3.5M | 547,115 | +8,526+1.56% | Add |
| STATE OF MICHIGAN RETIREMENT SYSTEM |
| 0.03% | 0.02% | #33 | $6.6M | 493,798 | $3.1M | 493,798 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #75 | $6.1M | 453,257 | $2.2M | 339,508 | +113,749+33.50% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #63 | $6.0M | 450,160 | $2.7M | 419,128 | +31,032+7.40% | Add |
| Sumitomo Mitsui Trust Group, Inc. |
| <0.01% | <0.01% | #54 | $5.6M | 417,488 | $3.1M | 484,270 | -66,782-13.79% | Reduce |
| Amova Asset Management Americas, Inc. |
| 0.07% | 0.04% | #25 | $5.6M | 417,488 | $3.1M | 484,270 | -66,782-13.79% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #59 | $4.9M | 364,764 | $86,849 | 13,634 | +351,130+2,575.40% | Add |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
| 0.3% | 0.16% | #19 | $4.7M | 351,741 | $2.1M | 323,374 | +28,367+8.77% | Add |
| Wellington Shields Capital Management, LLC |
| 0.58% | 0.32% | #16 | $4.6M | 339,733 | $2.2M | 339,733 | 00.00% | Unchanged |
| Wellington Shields & Co., LLC |
| 0.88% | 0.47% | #10 | $3.9M | 292,489 | $1.9M | 292,489 | 00.00% | Unchanged |
| Militia Capital Management LLC |
| 0.12% | — | #23 | $3.9M | 291,881 | $0 | 0 | +291,881 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #113 | $3.7M | 279,182 | $1.4M | 225,736 | +53,446+23.68% | Add |
| GILDER GAGNON HOWE & CO LLC |
| 0.04% | — | #29 | $3.7M | 278,490 | $0 | 0 | +278,490 | New Buy |
| TUDOR INVESTMENT CORP ET AL |
| 0.01% | <0.01% | #49 | $3.7M | 274,321 | $1.3M | 209,826 | +64,495+30.74% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #103 | $3.5M | 261,598 | $253,526 | 39,800 | +221,798+557.28% | Add |
| PERKINS CAPITAL MANAGEMENT INC |
| 2.53% | 1.43% | #4 | $3.2M | 239,000 | $1.5M | 239,000 | 00.00% | Unchanged |
| Bruce & Co., Inc. |
| 0.87% | 0.42% | #11 | $3.1M | 233,000 | $1.5M | 233,000 | 00.00% | Unchanged |
| FIRST MANHATTAN CO. LLC. |
| 0.01% | <0.01% | #46 | $3.1M | 230,600 | $1.5M | 230,600 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #106 | $2.8M | 209,320 | $921,268 | 144,626 | +64,694+44.73% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #100 | $2.5M | 189,065 | $793,965 | 124,641 | +64,424+51.69% | Add |
| FRED ALGER MANAGEMENT, LLC |
| 0.01% | — | #47 | $2.2M | 165,579 | $0 | 0 | +165,579 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #115 | $2.2M | 164,761 | $2.4M | 383,503 | -218,742-57.04% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #121 | $2.1M | 158,838 | $10.5M | 1.7M | -1.5M-90.37% | Reduce |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 1.63% | 1.4% | #6 | $2.1M | 157,500 | $1.5M | 235,000 | -77,500-32.98% | Reduce |
| Swiss National Bank |
| <0.01% | <0.01% | #84 | $1.8M | 136,500 | $671,398 | 105,400 | +31,100+29.51% | Add |
