| BAIN CAPITAL INVESTORS LLC |
| 12.01% | — | #4 | $578.4M | 26.3M | $0 | 0 | +26.3M | New Buy |
| Bain Capital Life Sciences Investors, LLC |
| 29.58% | — | #1 | $497.5M | 22.6M | $0 | 0 | +22.6M | New Buy |
| RTW INVESTMENTS, LP |
| 2.03% | — | #6 | $237.4M | 10.8M | $0 | 0 | +10.8M | New Buy |
| CANADA PENSION PLAN INVESTMENT BOARD |
| 0.09% | — | #20 | $160.9M | 7.3M | $0 | 0 | +7.3M | New Buy |
| Atlas Venture Life Science Advisors, LLC |
| 12.93% | — | #3 | $113.9M | 5.2M | $0 | 0 | +5.2M | New Buy |
| FMR LLC |
| <0.01% | — | #38 | $87.5M | 4.0M | $0 | 0 | +4.0M | New Buy |
| BlackRock, Inc. |
| <0.01% | — | #55 | $86.5M | 3.9M | $0 | 0 | +3.9M | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | — | #34 | $77.9M | 3.5M | $0 | 0 | +3.5M | New Buy |
| CITADEL ADVISORS LLC |
| 0.01% | — | #33 | $71.4M | 3.2M | $0 | 0 | +3.2M | New Buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.1% | — | #19 | $70.7M | 3.2M | $0 | 0 | +3.2M | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | — | #28 | $64.3M | 2.9M | $0 | 0 | +2.9M | New Buy |
| Royalty Pharma Sub-Manager, LLC |
| 22.36% | — | #2 | $54.1M | 2.5M | $0 | 0 | +2.5M | New Buy |
| Siren, L.L.C. |
| 0.99% | — | #8 | $48.8M | 2.2M | $0 | 0 | +2.2M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #64 | $37.3M | 1.7M | $0 | 0 | +1.7M | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #49 | $36.4M | 1.7M | $0 | 0 | +1.7M | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #54 | $25.0M | 1.1M | $0 | 0 | +1.1M | New Buy |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.11% | — | #17 | $24.2M | 1.1M | $0 | 0 | +1.1M | New Buy |
| Frazier Life Sciences Management, L.P. |
| 0.53% | — | #10 | $24.2M | 1.1M | $0 | 0 | +1.1M | New Buy |
| Trails Edge Capital Partners, LP |
| 3.44% | — | #5 | $21.7M | 984,786 | $0 | 0 | +984,786 | New Buy |
| UBS Group AG |
| <0.01% | — | #43 | $21.4M | 972,683 | $0 | 0 | +972,683 | New Buy |
| Jupiter Topco LLC |
| 0.01% | — | #32 | $21.3M | 970,857 | $0 | 0 | +970,857 | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #39 | $18.1M | 821,331 | $0 | 0 | +821,331 | New Buy |
| Deep Track Capital, LP |
| 0.22% | — | #13 | $15.4M | 700,000 | $0 | 0 | +700,000 | New Buy |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.18% | — | #14 | $13.6M | 616,720 | $0 | 0 | +616,720 | New Buy |
| Vestal Point Capital, LP |
| 0.3% | — | #11 | $12.7M | 575,000 | $0 | 0 | +575,000 | New Buy |
| Cormorant Asset Management, LP |
| 0.62% | — | #9 | $12.1M | 550,000 | $0 | 0 | +550,000 | New Buy |
| Catalio Capital Management, LP |
| 1.94% | — | #7 | $10.3M | 468,750 | $0 | 0 | +468,750 | New Buy |
| FEDERATED HERMES, INC. |
| 0.01% | — | #25 | $9.6M | 434,069 | $0 | 0 | +434,069 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | — | #63 | $9.3M | 421,034 | $0 | 0 | +421,034 | New Buy |
| FRANKLIN RESOURCES INC |
| <0.01% | — | #47 | $8.8M | 400,023 | $0 | 0 | +400,023 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #58 | $8.0M | 362,910 | $0 | 0 | +362,910 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | — | #61 | $7.8M | 354,431 | $0 | 0 | +354,431 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #53 | $6.4M | 290,128 | $0 | 0 | +290,128 | New Buy |
| SEVEN GRAND MANAGERS, LLC |
| 0.16% | — | #15 | $3.9M | 175,000 | $0 | 0 | +175,000 | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #37 | $3.4M | 154,838 | $0 | 0 | +154,838 | New Buy |
| EXCHANGE TRADED CONCEPTS, LLC |
| 0.02% | — | #23 | $3.4M | 152,501 | $0 | 0 | +152,501 | New Buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | — | #44 | $3.3M | 149,817 | $0 | 0 | +149,817 | New Buy |
| TD ASSET MANAGEMENT INC |
| <0.01% | — | #41 | $3.3M | 147,698 | $0 | 0 | +147,698 | New Buy |
| Aberdeen Group plc |
| <0.01% | — | #36 | $3.1M | 140,000 | $0 | 0 | +140,000 | New Buy |
| Nantahala Capital Management, LLC |
| 0.1% | — | #18 | $3.1M | 140,000 | $0 | 0 | +140,000 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #70 | $3.0M | 138,399 | $0 | 0 | +138,399 | New Buy |
| ALPS ADVISORS INC |
| 0.01% | — | #26 | $2.9M | 131,000 | $0 | 0 | +131,000 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #71 | $2.0M | 88,796 | $0 | 0 | +88,796 | New Buy |
| Avidity Partners Management LP |
| 0.28% | — | #12 | $1.8M | 80,000 | $0 | 0 | +80,000 | New Buy |
| Ghisallo Capital Management LLC |
| 0.01% | — | #31 | $1.7M | 75,000 | $0 | 0 | +75,000 | New Buy |
| Rock Springs Capital Management LP |
| 0.07% | — | #21 | $1.4M | 65,000 | $0 | 0 | +65,000 | New Buy |
| ALLIANCEBERNSTEIN L.P. |
| <0.01% | — | #72 | $1.3M | 61,090 | $0 | 0 | +61,090 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | — | #59 | $1.3M | 58,387 | $0 | 0 | +58,387 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #86 | $1.3M | 57,786 | $0 | 0 | +57,786 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | — | #83 | $1.2M | 56,510 | $0 | 0 | +56,510 | New Buy |
