| RA CAPITAL MANAGEMENT, L.P. |
| 0.76% | 0.92% | #7 | $87.0M | 10.9M | $87.2M | 10.9M | 00.00% | Unchanged |
| Rubric Capital Management LP |
| 0.63% | 0.68% | #8 | $68.4M | 8.5M | $64.2M | 8.0M | +540,861+6.76% | Add |
| ORBIMED ADVISORS LLC |
| 1.25% | 1.32% | #5 | $66.4M | 8.3M | $66.6M | 8.3M | 00.00% | Unchanged |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.63% | 0.71% | #9 | $60.1M | 7.5M | $60.3M | 7.5M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #98 | $42.5M | 5.3M | $40.2M | 5.0M | +299,065+5.97% | Add |
| Tyro Capital Management LLC |
| 8.01% | 2.59% | #1 | $35.7M | 4.5M | $23.8M | 3.0M | +1.5M+50.22% | Add |
| Aberdeen Group plc |
| 0.05% | 0.05% | #39 | $33.4M | 4.2M | $33.0M | 4.1M | +57,012+1.39% | Add |
| SR ONE CAPITAL MANAGEMENT, LP |
| 3.09% | 3.52% | #2 | $32.1M | 4.0M | $32.2M | 4.0M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #86 | $29.9M | 3.7M | $29.3M | 3.6M | +85,657+2.35% | Add |
| Capital World Investors |
| <0.01% | — | #69 | $22.1M | 2.8M | $0 | 0 | +2.8M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #110 | $20.5M | 2.6M | $20.4M | 2.5M | +11,024+0.43% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.02% | #58 | $20.2M | 2.5M | $48.0M | 6.0M | -3.5M-57.86% | Reduce |
| Janney Montgomery Scott LLC |
| 0.03% | 0.04% | #42 | $16.5M | 2.1M | $16.2M | 2.0M | +48,034+2.38% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #72 | $15.5M | 1.9M | $18.2M | 2.3M | -320,671-14.19% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #92 | $13.6M | 1.7M | $12.3M | 1.5M | +172,193+11.28% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.17% | 0.03% | #22 | $12.8M | 1.6M | $2.0M | 250,597 | +1.4M+539.08% | Add |
| GENERAL AMERICAN INVESTORS CO INC |
| 0.54% | 0.38% | #11 | $9.1M | 1.1M | $5.8M | 727,154 | +405,892+55.82% | Add |
| Third Point LLC |
| 0.17% | 0.39% | #24 | $8.0M | 1.0M | $8.0M | 1.0M | 00.00% | Unchanged |
| PEREGRINE CAPITAL MANAGEMENT LLC |
| 0.17% | — | #20 | $5.4M | 672,139 | $0 | 0 | +672,139 | New Buy |
| Tejara Capital Ltd |
| 2% | 0.56% | #3 | $4.9M | 607,039 | $1.7M | 210,400 | +396,639+188.52% | Add |
| ADAR1 Capital Management, LLC |
| 0.22% | 0.64% | #17 | $4.8M | 600,999 | $10.9M | 1.4M | -760,537-55.86% | Reduce |
| Pavaki Capital Management LLC |
| 1.62% | — | #4 | $4.6M | 579,600 | $0 | 0 | +579,600 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #138 | $4.5M | 566,829 | $4.1M | 510,551 | +56,278+11.02% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #106 | $4.5M | 566,563 | $14.8M | 1.8M | -1.3M-69.21% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #100 | $4.4M | 551,416 | $4.3M | 533,394 | +18,022+3.38% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #107 | $4.4M | 549,064 | $4.3M | 529,284 | +19,780+3.74% | Add |
| LEVIN CAPITAL STRATEGIES, L.P. |
| 0.29% | 0.34% | #15 | $4.4M | 548,965 | $4.4M | 552,561 | -3,596-0.65% | Reduce |
| Empire Life Investments Inc. |
| 0.21% | 0.25% | #18 | $3.8M | 471,856 | $4.0M | 499,150 | -27,294-5.47% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #129 | $3.7M | 463,256 | $2.3M | 285,728 | +177,528+62.13% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #96 | $3.7M | 461,384 | $3.7M | 464,681 | -3,297-0.71% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #88 | $3.7M | 461,001 | $3.6M | 446,307 | +14,694+3.29% | Add |
| FIL Ltd |
| <0.01% | <0.01% | #70 | $3.6M | 455,575 | $3.7M | 455,575 | 00.00% | Unchanged |
| K2 PRINCIPAL FUND, L.P. |
| 0.36% | 0.43% | #13 | $3.4M | 423,132 | $4.6M | 572,697 | -149,565-26.12% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #143 | $3.1M | 363,316 | $3.0M | 382,801 | -19,485-5.09% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #127 | $3.0M | 380,770 | $5.8M | 724,219 | -343,449-47.42% | Reduce |
| Eversept Partners, LP |
| 0.16% | 0.06% | #28 | $3.0M | 377,007 | $1.1M | 136,235 | +240,772+176.73% | Add |
| INVESTMENT MANAGEMENT ASSOCIATES INC /ADV |
| 0.61% | 0.69% | #10 | $3.0M | 373,491 | $2.9M | 359,074 | +14,417+4.02% | Add |
| FMR LLC |
| <0.01% | <0.01% | #154 | $2.8M | 349,164 | $2.7M | 342,042 | +7,122+2.08% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #94 | $2.6M | 318,583 | $4.2M | 525,224 | -206,641-39.34% | Reduce |
| Trexquant Investment LP |
| 0.01% | — | #50 | $2.3M | 286,733 | $0 | 0 | +286,733 | New Buy |
| Jump Financial, LLC |
| 0.02% | — | #46 | $2.0M | 255,200 | $0 | 0 | +255,200 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #148 | $1.9M | 232,813 | $2.1M | 255,737 | -22,924-8.96% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #161 | $1.8M | 229,100 | $7.0M | 700,414 | -471,314-67.29% | Reduce |
| FAS Wealth Partners, Inc. |
| 0.09% | 0.1% | #32 | $1.7M | 214,507 | $1.6M | 205,407 | +9,100+4.43% | Add |
| Hennion & Walsh Asset Management, Inc. |
| 0.04% | — | #41 | $1.4M | 175,614 | $0 | 0 | +175,614 | New Buy |
| Quinn Opportunity Partners LLC |
| 0.07% | 0.06% | #35 | $1.4M | 175,000 | $1.2M | 155,000 | +20,000+12.90% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #134 | $1.3M | 168,136 | $1.3M | 164,064 | +4,072+2.48% | Add |
| DAFNA Capital Management LLC |
| 0.25% | 0.25% | #16 | $1.3M | 164,285 | $1.1M | 139,285 | +25,000+17.95% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #122 | $1.3M | 161,342 | $1.2M | 150,696 | +10,646+7.06% | Add |
| Ishara Investments LP |
| 0.83% | — | #6 | $1.1M | 143,490 | $0 | 0 | +143,490 | New Buy |
