| FMR LLC |
| 0.01% | 0.01% | #62 | $227.0M | 6.6M | $177.5M | 6.3M | +280,800+4.47% | Add |
| GENERAL ATLANTIC, L.P. |
| 7.79% | 10.56% | #5 | $226.5M | 6.6M | $226.9M | 8.0M | -1.5M-18.43% | Reduce |
| Foresite Capital Management IV, LLC |
| 56.95% | 56.94% | #1 | $165.2M | 4.8M | $135.0M | 4.8M | 00.00% | Unchanged |
| venBio Partners LLC |
| 30.92% | 46.71% | #2 | $160.6M | 4.6M | $131.1M | 4.6M | +4,126+0.09% | Add |
| VIKING GLOBAL INVESTORS LP |
| 0.36% | 0.29% | #33 | $126.3M | 3.7M | $103.2M | 3.7M | 00.00% | Unchanged |
| EQT Fund Management S.a r.l. |
| 13.73% | 9.48% | #3 | $118.4M | 3.4M | $96.7M | 3.4M | 00.00% | Unchanged |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.22% | 1.04% | #24 | $116.7M | 3.4M | $88.3M | 3.1M | +250,000+8.00% | Add |
| Bain Capital Life Sciences Investors, LLC |
| 5.5% | 6.82% | #8 | $92.5M | 2.7M | $75.6M | 2.7M | 00.00% | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | 0.01% | #60 | $82.7M | 2.4M | $59.9M | 2.1M | +274,034+12.93% | Add |
| Polar Capital Holdings Plc |
| 0.19% | 0.08% | #37 | $80.4M | 2.3M | $22.1M | 781,016 | +1.5M+197.87% | Add |
| Point72 Asset Management, L.P. |
| 0.06% | 0.04% | #45 | $56.8M | 1.6M | $28.4M | 1.0M | +634,184+62.98% | Add |
| Commodore Capital LP |
| 2.93% | 3.14% | #14 | $49.3M | 1.4M | $54.2M | 1.9M | -493,970-25.74% | Reduce |
| Novo Holdings A/S |
| 2.82% | 4.01% | #15 | $48.4M | 1.4M | $49.4M | 1.8M | -350,000-20.00% | Reduce |
| Saturn V Capital Management LP |
| 6.52% | 6.15% | #6 | $45.4M | 1.3M | $33.9M | 1.2M | +112,720+9.38% | Add |
| TCG Crossover Management, LLC |
| 0.84% | — | #28 | $34.9M | 1.0M | $0 | 0 | +1.0M | New Buy |
| Sofinnova Investments, Inc. |
| 1.58% | 0.88% | #19 | $30.5M | 881,299 | $23.1M | 818,328 | +62,971+7.70% | Add |
| 5AM Venture Management, LLC |
| 9.58% | 6.26% | #4 | $27.6M | 797,600 | $22.5M | 797,600 | 00.00% | Unchanged |
| Seven Fleet Capital Management LP |
| 4.42% | 1.55% | #12 | $26.8M | 774,501 | $4.9M | 172,731 | +601,770+348.39% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #99 | $26.7M | 771,454 | $21.4M | 757,213 | +14,241+1.88% | Add |
| Cormorant Asset Management, LP |
| 1.32% | 1.42% | #21 | $25.9M | 750,000 | $28.3M | 1.0M | -250,000-25.00% | Reduce |
| Soleus Capital Management, L.P. |
| 0.87% | 0.8% | #27 | $25.3M | 730,907 | $19.8M | 702,052 | +28,855+4.11% | Add |
| Jones Hill Capital LP |
| 4.98% | 1.01% | #9 | $23.4M | 677,879 | $4.7M | 167,014 | +510,865+305.88% | Add |
| Patient Square Capital LP |
| 3.6% | 2.47% | #13 | $23.2M | 671,209 | $13.9M | 493,000 | +178,209+36.15% | Add |
| Foresite Capital Management V, LLC |
| 6.34% | 2.02% | #7 | $23.0M | 664,142 | $5.5M | 194,125 | +470,017+242.12% | Add |
| Kynam Capital Management, LP |
| 1.26% | 1.12% | #23 | $22.9M | 661,795 | $18.1M | 640,395 | +21,400+3.34% | Add |
| Rock Springs Capital Management LP |
| 1.09% | 1.07% | #26 | $22.4M | 648,333 | $18.2M | 645,533 | +2,800+0.43% | Add |
| Elmind Capital, LP |
| 4.57% | 3.82% | #11 | $18.2M | 525,750 | $13.4M | 475,750 | +50,000+10.51% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #56 | $18.1M | 524,302 | $13.1M | 462,251 | +62,051+13.42% | Add |
| DV EQUITIES, LLC |
| 2.39% | — | #16 | $16.7M | 482,524 | $0 | 0 | +482,524 | New Buy |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #63 | $16.3M | 471,402 | $9.1M | 321,157 | +150,245+46.78% | Add |
| Octagon Capital Advisors LP |
| 1.42% | 0.52% | #20 | $15.8M | 456,721 | $4.7M | 165,000 | +291,721+176.80% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #66 | $14.8M | 427,403 | $5.1M | 181,946 | +245,457+134.91% | Add |
| Alyeska Investment Group, L.P. |
| 0.04% | 0.01% | #48 | $14.1M | 406,829 | $3.5M | 125,000 | +281,829+225.46% | Add |
| Eversept Partners, LP |
| 0.69% | 0.61% | #29 | $13.4M | 386,383 | $11.5M | 406,960 | -20,577-5.06% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #77 | $12.4M | 358,270 | $12.5M | 442,256 | -83,986-18.99% | Reduce |
| Ikarian Capital, LLC |
| 1.13% | 1.12% | #25 | $10.7M | 308,856 | $13.8M | 486,856 | -178,000-36.56% | Reduce |
| Tetragon Partners GP Ltd |
| 1.61% | 1.22% | #18 | $10.2M | 295,627 | $6.3M | 221,611 | +74,016+33.40% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #79 | $8.8M | 254,790 | $2.0M | 71,941 | +182,849+254.17% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #81 | $8.7M | 250,385 | $4.8M | 168,630 | +81,755+48.48% | Add |
| EcoR1 Capital, LLC |
| 0.4% | — | #32 | $8.1M | 235,000 | $0 | 0 | +235,000 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #90 | $7.5M | 217,963 | $1.3M | 45,200 | +172,763+382.22% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #65 | $7.5M | 216,640 | $3.6M | 126,076 | +90,564+71.83% | Add |
| ORBIMED ADVISORS LLC |
| 0.13% | 0.12% | #40 | $7.1M | 205,400 | $5.8M | 205,400 | 00.00% | Unchanged |
| Walleye Capital LLC |
| 0.02% | — | #55 | $6.9M | 200,419 | $0 | 0 | +200,419 | New Buy |
| Kalehua Capital Management LLC |
| 4.93% | 3.97% | #10 | $6.9M | 198,772 | $5.6M | 198,772 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #105 | $5.8M | 168,631 | $4.3M | 152,945 | +15,686+10.26% | Add |
| Cinctive Capital Management LP |
| 0.21% | — | #36 | $5.6M | 161,113 | $0 | 0 | +161,113 | New Buy |
| HighVista Strategies LLC |
| 1.27% | 0.76% | #22 | $5.5M | 160,494 | $2.8M | 97,866 | +62,628+63.99% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #96 | $5.2M | 149,978 | $4.0M | 142,929 | +7,049+4.93% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #68 | $4.8M | 139,850 | $2.0M | 71,210 | +68,640+96.39% | Add |
