| JPMORGAN CHASE & CO |
| 0.19% | 0.16% | #133 | $3.51B | 12.9M | $2.50B | 13.4M | -521,321-3.89% | Reduce |
| BlackRock, Inc. |
| 0.04% | 0.04% | #308 | $2.96B | 10.9M | $2.14B | 10.7M | +237,270+2.22% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.24% | 0.28% | #117 | $2.45B | 9.0M | $2.44B | 12.2M | -3.2M-25.96% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.04% | 0.03% | #348 | $1.69B | 6.2M | $1.20B | 6.0M | +219,720+3.66% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.07% | 0.06% | #230 | $1.57B | 5.8M | $1.13B | 5.6M | +137,945+2.44% | Add |
| FMR LLC |
| 0.06% | 0.03% | #241 | $1.48B | 5.5M | $510.8M | 2.6M | +2.9M+113.42% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.19% | 0.18% | #134 | $1.10B | 4.0M | $953.7M | 4.8M | -727,855-15.26% | Reduce |
| STATE STREET CORP |
| 0.03% | 0.02% | #391 | $992.3M | 3.7M | $683.5M | 3.4M | +238,146+6.97% | Add |
| Duquesne Family Office LLC |
| 16.6% | 18.14% | #2 | $864.9M | 3.2M | $612.7M | 3.1M | +122,700+4.01% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.04% | 0.03% | #332 | $744.6M | 2.8M | $553.8M | 2.8M | -25,915-0.93% | Reduce |
| FRANKLIN RESOURCES INC |
| 0.15% | 0.11% | #157 | $739.9M | 2.7M | $497.0M | 2.5M | +240,578+9.68% | Add |
| Castle Hook Partners LP |
| 3.23% | 10.19% | #16 | $704.8M | 2.6M | $505.9M | 2.5M | +66,466+2.63% | Add |
| COATUE MANAGEMENT LLC |
| 1.4% | 1.75% | #39 | $680.0M | 2.5M | $508.3M | 2.5M | -36,752-1.45% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| 0.22% | 0.2% | #123 | $628.1M | 2.3M | $442.6M | 2.3M | +70,579+3.10% | Add |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 2.78% | 3.66% | #18 | $602.2M | 2.2M | $641.4M | 3.2M | -989,000-30.84% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.05% | 0.02% | #277 | $578.2M | 2.1M | $164.6M | 822,831 | +1.3M+158.86% | Add |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.18% | 0.14% | #142 | $535.1M | 2.0M | $408.0M | 2.0M | -68,715-3.37% | Reduce |
| NORGES BANK |
| 0.05% | 0.03% | #280 | $496.2M | 1.8M | $202.5M | 1.4M | +396,350+27.68% | Add |
| FRED ALGER MANAGEMENT, LLC |
| 1.61% | 1.54% | #33 | $482.6M | 1.8M | $351.3M | 1.8M | +21,537+1.23% | Add |
| Sofinnova Investments, Inc. |
| 21.76% | 11.78% | #1 | $420.8M | 1.6M | $310.0M | 1.6M | 00.00% | Unchanged |
| Capital World Investors |
| 0.05% | 0.04% | #288 | $408.4M | 1.5M | $293.6M | 1.5M | +36,412+2.48% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.18% | 0.13% | #137 | $408.2M | 1.5M | $238.3M | 1.2M | +311,974+26.18% | Add |
| JANE STREET GROUP, LLC |
| 0.03% | 0.01% | #371 | $391.9M | 1.4M | $100.0M | 499,977 | +943,609+188.73% | Add |
| MAVERICK CAPITAL LTD |
| 3.25% | 2.7% | #15 | $368.3M | 1.4M | $234.3M | 1.2M | +185,030+15.79% | Add |
| D. E. Shaw & Co., Inc. |
| 0.17% | 0.06% | #151 | $347.3M | 1.3M | $98.3M | 491,336 | +787,919+160.36% | Add |
| MORGAN STANLEY |
| 0.02% | 0.01% | #477 | $345.9M | 1.3M | $206.6M | 1.3M | -9,070-0.71% | Reduce |
| FEDERATED HERMES, INC. |
| 0.44% | 0.35% | #81 | $309.2M | 1.1M | $218.0M | 1.1M | +48,938+4.49% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.2% | 0.16% | #129 | $305.0M | 1.1M | $226.2M | 1.1M | -7,079-0.63% | Reduce |
| Clearbridge Investments, LLC |
| 0.23% | 0.16% | #121 | $276.4M | 1.0M | $178.7M | 893,322 | +125,003+13.99% | Add |
| RTW INVESTMENTS, LP |
| 2.32% | 2.49% | #23 | $271.5M | 1.0M | $250.0M | 1.3M | -250,000-20.00% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| 0.05% | 0.04% | #262 | $249.4M | 918,609 | $174.5M | 872,640 | +45,969+5.27% | Add |
| Invesco Ltd. |
| 0.02% | 0.04% | #471 | $237.1M | 873,332 | $251.7M | 1.3M | -385,045-30.60% | Reduce |
| NORTHERN TRUST CORP |
| 0.03% | 0.02% | #412 | $227.1M | 836,508 | $157.7M | 788,445 | +48,063+6.10% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.04% | 0.03% | #319 | $226.2M | 833,376 | $150.6M | 752,936 | +80,440+10.68% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.03% | 0.02% | #393 | $218.9M | 806,536 | $142.5M | 712,748 | +93,788+13.16% | Add |
| NWI MANAGEMENT LP |
| 9.58% | 8.8% | #3 | $207.0M | 762,603 | $190.2M | 830,303 | -67,700-8.15% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #527 | $200.0M | 736,637 | $146.7M | 733,669 | +2,968+0.40% | Add |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.64% | 0.63% | #62 | $197.2M | 726,628 | $150.9M | 754,729 | -28,101-3.72% | Reduce |
| ARK Investment Management LLC |
| 1.21% | 1.06% | #45 | $187.0M | 688,855 | $136.8M | 684,255 | +4,600+0.67% | Add |
| Sumitomo Mitsui Trust Group, Inc. |
| 0.1% | 0.09% | #197 | $174.7M | 643,643 | $138.5M | 692,368 | -48,725-7.04% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | 0.01% | #529 | $163.4M | 602,058 | $126.3M | 631,338 | -29,280-4.64% | Reduce |
| Chevy Chase Trust Holdings, LLC |
| 0.42% | 0.34% | #85 | $162.8M | 599,856 | $117.4M | 587,030 | +12,826+2.18% | Add |
| RAYMOND JAMES FINANCIAL INC |
| 0.04% | 0.03% | #310 | $161.0M | 593,083 | $112.3M | 591,043 | +2,040+0.35% | Add |
| WORLDQUANT MILLENNIUM ADVISORS LLC |
| 0.55% | 0.27% | #69 | $160.6M | 591,460 | $71.3M | 356,459 | +235,001+65.93% | Add |
| CITADEL ADVISORS LLC |
| 0.02% | 0.01% | #483 | $157.6M | 580,507 | $47.1M | 235,482 | +345,025+146.52% | Add |
| UBS Group AG |
| 0.02% | 0.01% | #468 | $150.3M | 553,739 | $84.6M | 422,899 | +130,840+30.94% | Add |
| Legal & General Group Plc |
| 0.03% | 0.02% | #377 | $150.1M | 553,114 | $99.6M | 498,141 | +54,973+11.04% | Add |
| Bank of New York Mellon Corp |
| 0.02% | 0.02% | #424 | $149.3M | 549,927 | $133.9M | 669,722 | -119,795-17.89% | Reduce |
| MAPLELANE CAPITAL, LLC |
| 2.69% | 4.86% | #20 | $148.5M | 547,000 | $135.8M | 474,862 | +72,138+15.19% | Add |
| FIRST TRUST ADVISORS LP |
| 0.08% | 0.08% | #220 | $138.8M | 511,214 | $105.8M | 528,798 | -17,584-3.33% | Reduce |
