| EQT Fund Management S.a r.l. |
| 8.15% | 11.1% | #4 | $70.3M | 5.3M | $113.3M | 4.9M | +358,680+7.28% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.4% | 0.85% | #9 | $46.4M | 3.5M | $80.3M | 3.5M | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #43 | $25.8M | 1.9M | $25.7M | 1.1M | +821,918+73.45% | Add |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 8.32% | 15.83% | #3 | $25.6M | 1.9M | $44.3M | 1.9M | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #46 | $23.4M | 1.6M | $32.1M | 1.5M | +93,712+6.42% | Add |
| RTW INVESTMENTS, LP |
| 0.17% | 0.34% | #14 | $20.0M | 1.5M | $34.5M | 1.5M | 00.00% | Unchanged |
| Nan Fung Group Holdings Ltd |
| 14.56% | 27.32% | #1 | $19.2M | 1.4M | $33.1M | 1.4M | 00.00% | Unchanged |
| Point72 Asset Management, L.P. |
| 0.02% | <0.01% | #27 | $19.1M | 1.4M | $840,905 | 36,577 | +1.4M+3,823.36% | Add |
| Andera Partners |
| 8.96% | 24.66% | #2 | $18.5M | 1.4M | $43.6M | 1.9M | -505,372-26.64% | Reduce |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.21% | 0.46% | #13 | $16.1M | 1.2M | $27.8M | 1.2M | 00.00% | Unchanged |
| Vestal Point Capital, LP |
| 0.31% | — | #11 | $13.3M | 1.0M | $0 | 0 | +1.0M | New Buy |
| Jupiter Topco LLC |
| <0.01% | — | #37 | $11.9M | 896,700 | $0 | 0 | +896,700 | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #72 | $11.8M | 886,538 | $15.5M | 673,571 | +212,967+31.62% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #65 | $11.7M | 881,895 | $10.5M | 455,051 | +426,844+93.80% | Add |
| BAKER BROS. ADVISORS LP |
| 0.06% | 0.11% | #18 | $11.3M | 847,390 | $19.5M | 847,390 | 00.00% | Unchanged |
| Defilade Capital Management, L.P. |
| 1.41% | 2.19% | #6 | $10.5M | 793,145 | $15.6M | 678,589 | +114,556+16.88% | Add |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | 0.01% | #39 | $10.0M | 755,018 | $11.3M | 492,938 | +262,080+53.17% | Add |
| Alyeska Investment Group, L.P. |
| 0.02% | 0.05% | #25 | $9.4M | 704,425 | $16.7M | 726,362 | -21,937-3.02% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | — | #31 | $8.3M | 627,015 | $0 | 0 | +627,015 | New Buy |
| Affinity Asset Advisors, LLC |
| 0.3% | — | #12 | $6.6M | 500,100 | $0 | 0 | +500,100 | New Buy |
| Velan Capital Investment Management LP |
| 3.65% | 6.43% | #5 | $6.0M | 451,255 | $10.3M | 446,255 | +5,000+1.12% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #52 | $5.5M | 413,553 | $6.9M | 298,375 | +115,178+38.60% | Add |
| FEDERATED HERMES, INC. |
| 0.01% | 0.01% | #35 | $4.3M | 325,000 | $7.5M | 325,000 | 00.00% | Unchanged |
| GREAT POINT PARTNERS LLC |
| 0.82% | 1.72% | #7 | $4.3M | 325,000 | $7.5M | 325,000 | 00.00% | Unchanged |
| Freestone Grove Partners LP |
| 0.03% | 0.05% | #24 | $4.1M | 306,328 | $7.8M | 337,291 | -30,963-9.18% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #70 | $4.0M | 301,759 | $5.7M | 248,611 | +53,148+21.38% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #78 | $3.9M | 293,516 | $4.1M | 179,511 | +114,005+63.51% | Add |
| MORGAN STANLEY |
| <0.01% | — | #71 | $3.9M | 290,174 | $0 | 0 | +290,174 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | — | #62 | $3.5M | 261,640 | $0 | 0 | +261,640 | New Buy |
| Caption Management, LLC |
| 0.02% | — | #28 | $3.2M | 244,481 | $0 | 0 | +244,481 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #69 | $2.6M | 192,995 | $3.5M | 154,323 | +38,672+25.06% | Add |
| Blue Owl Capital Holdings LP |
| 0.35% | 0.62% | #10 | $2.4M | 180,000 | $2.3M | 100,000 | +80,000+80.00% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #55 | $2.4M | 178,730 | $45,475 | 1,978 | +176,752+8,935.89% | Add |
| Eversept Partners, LP |
| 0.12% | 0.07% | #16 | $2.3M | 174,460 | $1.3M | 54,680 | +119,780+219.06% | Add |
| ORBIMED ADVISORS LLC |
| 0.04% | — | #21 | $2.1M | 161,000 | $0 | 0 | +161,000 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #49 | $1.8M | 133,350 | $50,578 | 2,200 | +131,150+5,961.36% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #67 | $1.8M | 133,072 | $2.2M | 94,948 | +38,124+40.15% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | — | #77 | $1.7M | 125,684 | $0 | 0 | +125,684 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #86 | $1.6M | 119,927 | $1.4M | 60,993 | +58,934+96.62% | Add |
| NEXTBio Capital Management LP |
| 0.73% | 1.96% | #8 | $1.6M | 119,063 | $4.2M | 184,063 | -65,000-35.31% | Reduce |
| LMR Partners LLP |
| 0.01% | — | #36 | $1.6M | 118,436 | $0 | 0 | +118,436 | New Buy |
| Longaeva Partners L.P. |
| 0.03% | — | #23 | $1.5M | 116,611 | $0 | 0 | +116,611 | New Buy |
| Holocene Advisors, LP |
| <0.01% | — | #41 | $1.5M | 111,132 | $0 | 0 | +111,132 | New Buy |
| ADAR1 Capital Management, LLC |
| 0.06% | 0.25% | #17 | $1.4M | 104,035 | $4.2M | 184,062 | -80,027-43.48% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #73 | $1.3M | 101,404 | $1.8M | 79,755 | +21,649+27.14% | Add |
| SEVEN GRAND MANAGERS, LLC |
| 0.05% | 0.25% | #20 | $1.2M | 90,568 | $3.8M | 164,670 | -74,102-45.00% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #64 | $1.2M | 88,199 | $1.7M | 72,582 | +15,617+21.52% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #68 | $1.2M | 87,018 | $2.1M | 91,429 | -4,411-4.82% | Reduce |
| Avidity Partners Management LP |
| 0.16% | — | #15 | $996,750 | 75,000 | $0 | 0 | +75,000 | New Buy |
| Quadrature Capital Ltd |
| 0.01% | — | #32 | $921,143 | 69,311 | $0 | 0 | +69,311 | New Buy |
