| FMR LLC |
| 0.01% | 0.01% | #57 | $122.7M | 32.7M | $150.2M | 32.0M | +759,300+2.38% | Add |
| Kynam Capital Management, LP |
| 4.5% | 4.35% | #1 | $81.4M | 21.7M | $70.6M | 15.0M | +6.7M+44.56% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #89 | $65.8M | 17.6M | $24.6M | 5.2M | +12.3M+235.86% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #63 | $56.6M | 15.1M | $48.0M | 10.2M | +4.9M+47.83% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #84 | $44.1M | 11.7M | $26.6M | 5.7M | +6.1M+107.42% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.59% | 0.93% | #10 | $39.1M | 10.4M | $47.5M | 10.1M | +340,361+3.37% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #101 | $32.0M | 8.5M | $41.0M | 8.7M | -207,661-2.38% | Reduce |
| Point72 Asset Management, L.P. |
| 0.03% | 0.05% | #29 | $29.3M | 7.8M | $37.0M | 7.9M | -64,357-0.82% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #64 | $19.4M | 5.2M | $16.8M | 3.6M | +1.6M+44.26% | Add |
| Venrock Adviser, LLC |
| 0.57% | 1.75% | #12 | $18.7M | 5.0M | $46.9M | 10.0M | -5.0M-50.09% | Reduce |
| BAKER BROS. ADVISORS LP |
| 0.09% | 0.13% | #24 | $18.7M | 5.0M | $23.4M | 5.0M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #91 | $17.5M | 4.7M | $9.7M | 2.1M | +2.6M+126.40% | Add |
| Elmind Capital, LP |
| 4.29% | 6.07% | #2 | $17.1M | 4.6M | $21.4M | 4.6M | 00.00% | Unchanged |
| Nextech Invest Ltd. |
| 0.79% | 1.47% | #5 | $16.7M | 4.4M | $20.9M | 4.4M | 00.00% | Unchanged |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #43 | $15.5M | 4.1M | $12.7M | 2.7M | +1.4M+52.49% | Add |
| Eversept Partners, LP |
| 0.69% | 0.79% | #7 | $13.3M | 3.6M | $15.0M | 3.2M | +369,983+11.60% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #77 | $13.0M | 3.5M | $14.7M | 3.1M | +348,204+11.16% | Add |
| Siren, L.L.C. |
| 0.26% | 0.45% | #17 | $13.0M | 3.5M | $16.3M | 3.5M | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.58% | 0.94% | #11 | $12.6M | 3.4M | $16.0M | 3.4M | -45,072-1.32% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #81 | $12.5M | 3.3M | $27.7M | 5.9M | -2.6M-43.55% | Reduce |
| MARSHALL WACE, LLP |
| 0.01% | 0.02% | #48 | $11.3M | 3.0M | $19.4M | 4.1M | -1.1M-26.92% | Reduce |
| Woodline Partners LP |
| 0.02% | 0.04% | #34 | $7.7M | 2.0M | $9.4M | 2.0M | +39,385+1.97% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #103 | $7.5M | 2.0M | $6.9M | 1.5M | +543,813+37.25% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #85 | $7.0M | 1.9M | $9.1M | 1.9M | -70,630-3.66% | Reduce |
| Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #54 | $6.8M | 1.8M | $10.6M | 2.2M | -425,019-18.89% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #120 | $6.6M | 1.8M | $3.7M | 794,755 | +956,412+120.34% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #70 | $6.3M | 1.7M | $17.2M | 3.7M | -2.0M-53.94% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #97 | $6.3M | 1.7M | $2.9M | 612,141 | +1.1M+173.66% | Add |
| TUDOR INVESTMENT CORP ET AL |
| 0.01% | — | #51 | $5.4M | 1.4M | $0 | 0 | +1.4M | New Buy |
| Caption Management, LLC |
| 0.02% | 0.05% | #33 | $5.3M | 1.4M | $8.9M | 1.9M | -473,224-25.00% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #88 | $4.8M | 1.3M | $5.2M | 1.1M | +164,547+14.92% | Add |
| Seven Fleet Capital Management LP |
| 0.67% | 0.55% | #8 | $4.1M | 1.1M | $1.7M | 371,398 | +714,000+192.25% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.43% | 0.16% | #13 | $3.3M | 879,000 | $1.0M | 220,000 | +659,000+299.55% | Add |
| Ally Bridge Group (NY) LLC |
| 2.57% | 3.42% | #3 | $2.9M | 775,000 | $4.2M | 900,000 | -125,000-13.89% | Reduce |
| DV EQUITIES, LLC |
| 0.38% | — | #14 | $2.7M | 714,000 | $0 | 0 | +714,000 | New Buy |
| GILDER GAGNON HOWE & CO LLC |
| 0.03% | 0.06% | #32 | $2.6M | 704,423 | $5.3M | 1.1M | -415,886-37.12% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #113 | $2.6M | 684,539 | $1.4M | 289,868 | +394,671+136.16% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #98 | $2.5M | 663,038 | $2.2M | 463,421 | +199,617+43.07% | Add |
| FIRST TRUST ADVISORS LP |
| <0.01% | <0.01% | #83 | $2.2M | 599,696 | $2.7M | 568,562 | +31,134+5.48% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #124 | $2.1M | 549,875 | $605,341 | 128,796 | +421,079+326.93% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #133 | $2.0M | 544,573 | $14.5M | 3.1M | -2.5M-82.32% | Reduce |
| Ensign Peak Advisors, Inc |
| <0.01% | 0.01% | #66 | $1.9M | 505,055 | $2.8M | 592,473 | -87,418-14.75% | Reduce |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #107 | $1.8M | 484,222 | $1.8M | 380,160 | +104,062+27.37% | Add |
| SCHULHOFF & CO INC |
| 0.72% | 0.92% | #6 | $1.8M | 477,550 | $2.2M | 477,550 | 00.00% | Unchanged |
| Exome Asset Management LLC |
| 1.06% | 1.27% | #4 | $1.7M | 460,067 | $2.5M | 521,468 | -61,401-11.77% | Reduce |
| Nuveen, LLC |
| <0.01% | — | #114 | $1.7M | 448,041 | $0 | 0 | +448,041 | New Buy |
| DAFNA Capital Management LLC |
| 0.31% | 0.25% | #15 | $1.6M | 438,407 | $1.1M | 230,000 | +208,407+90.61% | Add |
| Assenagon Asset Management S.A. |
| <0.01% | <0.01% | #75 | $1.4M | 364,173 | $1.7M | 364,173 | 00.00% | Unchanged |
| Jump Financial, LLC |
| 0.01% | <0.01% | #47 | $1.3M | 347,400 | $50,403 | 10,724 | +336,676+3,139.46% | Add |
| Swiss National Bank |
| <0.01% | <0.01% | #104 | $1.2M | 325,400 | $1.5M | 319,600 | +5,800+1.81% | Add |
