| Jupiter Topco LLC |
| 0.03% | — | #40 | $77.3M | 11.2M | $0 | 0 | +11.2M | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #77 | $51.4M | 7.4M | $9.0M | 1.3M | +6.1M+475.92% | Add |
| Squadron Capital Management LLC |
| 15.78% | 21.61% | #1 | $50.9M | 7.4M | $59.0M | 8.5M | -1.1M-13.27% | Reduce |
| Venrock Adviser, LLC |
| 1.44% | 1.26% | #7 | $47.4M | 6.8M | $33.7M | 4.8M | +2.0M+41.31% | Add |
| Spruce Street Capital LP |
| 8.68% | 10.34% | #2 | $44.2M | 6.4M | $43.0M | 6.3M | +129,214+2.06% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.05% | 0.05% | #37 | $33.0M | 4.8M | $33.2M | 4.8M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #78 | $30.9M | 4.5M | $21.4M | 3.1M | +1.4M+44.97% | Add |
| Jones Hill Capital LP |
| 5.38% | 0.51% | #3 | $25.3M | 3.7M | $2.4M | 342,752 | +3.3M+966.39% | Add |
| ORBIMED ADVISORS LLC |
| 0.47% | 0.65% | #15 | $25.1M | 3.6M | $32.8M | 4.7M | -1.1M-23.00% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #83 | $17.4M | 2.5M | $2.5M | 357,040 | +2.2M+605.12% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #76 | $17.3M | 2.5M | $5.9M | 848,683 | +1.6M+193.70% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #52 | $16.3M | 2.4M | $27.2M | 3.9M | -1.5M-39.55% | Reduce |
| MARSHALL WACE, LLP |
| 0.01% | 0.03% | #46 | $15.5M | 2.2M | $31.2M | 4.5M | -2.2M-49.87% | Reduce |
| Ikarian Capital, LLC |
| 1.58% | 1.52% | #5 | $14.9M | 2.1M | $18.7M | 2.7M | -540,000-20.09% | Reduce |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.09% | 0.11% | #31 | $14.8M | 2.1M | $14.8M | 2.1M | 00.00% | Unchanged |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #63 | $13.4M | 1.9M | $3.7M | 533,258 | +1.4M+263.42% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.17% | 0.1% | #25 | $12.9M | 1.9M | $5.9M | 842,106 | +1.0M+120.69% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | <0.01% | #45 | $10.5M | 1.5M | $1.8M | 252,457 | +1.3M+502.36% | Add |
| STEMPOINT CAPITAL LP |
| 1.44% | 0.77% | #6 | $10.1M | 1.5M | $4.2M | 597,409 | +862,684+144.40% | Add |
| Commodore Capital LP |
| 0.59% | 0.26% | #12 | $9.9M | 1.4M | $4.4M | 633,901 | +791,099+124.80% | Add |
| Polar Capital Holdings Plc |
| 0.02% | 0.03% | #41 | $9.3M | 1.3M | $9.8M | 1.4M | -74,193-5.24% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #75 | $8.1M | 1.2M | $169,128 | 24,300 | +1.1M+4,717.55% | Add |
| Sio Capital Management, LLC |
| 1.15% | 0.96% | #9 | $6.9M | 1.0M | $6.7M | 965,000 | +38,562+4.00% | Add |
| Opaleye Management Inc. |
| 0.59% | 0.86% | #13 | $6.5M | 935,000 | $6.5M | 935,000 | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #93 | $6.2M | 898,198 | $0 | 0 | +898,198 | New Buy |
| GREAT POINT PARTNERS LLC |
| 1.1% | 1.35% | #10 | $5.8M | 842,106 | $5.9M | 842,106 | 00.00% | Unchanged |
| Soleus Capital Management, L.P. |
| 0.2% | 0.24% | #22 | $5.8M | 842,106 | $5.9M | 842,106 | 00.00% | Unchanged |
| Boxer Capital Management, LLC |
| 0.44% | 0.77% | #16 | $5.8M | 842,106 | $5.9M | 842,106 | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #88 | $5.6M | 812,059 | $876,549 | 125,941 | +686,118+544.79% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #80 | $5.4M | 786,257 | $1.1M | 157,734 | +628,523+398.47% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #84 | $5.3M | 767,624 | $5.0M | 723,339 | +44,285+6.12% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #72 | $5.1M | 734,191 | $3.1M | 449,811 | +284,380+63.22% | Add |
| Corient Private Wealth LLC |
| <0.01% | 0.01% | #60 | $4.9M | 719,582 | $5.0M | 719,582 | 00.00% | Unchanged |
| Qube Research & Technologies Ltd |
| <0.01% | 0.01% | #57 | $4.8M | 691,545 | $4.5M | 653,333 | +38,212+5.85% | Add |
| Walleye Capital LLC |
| 0.02% | — | #43 | $4.3M | 616,238 | $0 | 0 | +616,238 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.05% | 0.07% | #36 | $3.9M | 564,759 | $5.1M | 729,055 | -164,296-22.54% | Reduce |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | 0.01% | #56 | $3.8M | 543,394 | $5.0M | 712,540 | -169,146-23.74% | Reduce |
| Integral Health Asset Management, LLC |
| 0.14% | 0.15% | #28 | $3.5M | 500,000 | $3.1M | 450,000 | +50,000+11.11% | Add |
| ADAR1 Capital Management, LLC |
| 0.14% | 0.19% | #27 | $3.1M | 451,918 | $3.1M | 451,918 | 00.00% | Unchanged |
| Knott David M Jr |
| 1.66% | 1.85% | #4 | $3.1M | 451,000 | $3.1M | 439,300 | +11,700+2.66% | Add |
| HighVista Strategies LLC |
| 0.7% | — | #11 | $3.1M | 445,799 | $0 | 0 | +445,799 | New Buy |
| AdvisorShares Investments LLC |
| 0.37% | 0.38% | #18 | $3.0M | 438,901 | $2.1M | 295,872 | +143,029+48.34% | Add |
| Birchview Capital, LP |
| 1.28% | 1.62% | #8 | $2.8M | 408,100 | $2.8M | 409,387 | -1,287-0.31% | Reduce |
| DIADEMA PARTNERS LP |
| 0.31% | 0.24% | #21 | $2.5M | 361,367 | $1.4M | 200,842 | +160,525+79.93% | Add |
| PARSONS CAPITAL MANAGEMENT INC/RI |
| 0.11% | 0.11% | #29 | $2.5M | 354,069 | $2.5M | 352,500 | +1,569+0.45% | Add |
| Seven Fleet Capital Management LP |
| 0.4% | — | #17 | $2.4M | 348,265 | $0 | 0 | +348,265 | New Buy |
| Harvest Investment Services, LLC |
| 0.36% | — | #19 | $2.4M | 340,890 | $0 | 0 | +340,890 | New Buy |
| Woodline Partners LP |
| 0.01% | 0.01% | #50 | $2.3M | 328,421 | $2.9M | 421,052 | -92,631-22.00% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #79 | $2.2M | 318,902 | $1.6M | 224,846 | +94,056+41.83% | Add |
| SEVEN GRAND MANAGERS, LLC |
| 0.09% | 0.15% | #30 | $2.2M | 315,788 | $2.2M | 315,788 | 00.00% | Unchanged |
