| NEA Management Company, LLC |
| 9.49% | 7.6% | #1 | $150.7M | 24.5M | $133.6M | 24.5M | 00.00% | Unchanged |
| Bain Capital Life Sciences Investors, LLC |
| 6.45% | 8.67% | #2 | $108.4M | 17.6M | $96.1M | 17.6M | 00.00% | Unchanged |
| Venrock Adviser, LLC |
| 2.75% | 2.8% | #6 | $90.8M | 14.7M | $75.0M | 13.7M | +1.0M+7.32% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.87% | 0.87% | #12 | $83.6M | 13.6M | $74.1M | 13.6M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #83 | $77.0M | 12.5M | $61.6M | 11.3M | +1.2M+10.66% | Add |
| TCG Crossover Management, LLC |
| 1.83% | 1.93% | #8 | $76.2M | 12.4M | $67.5M | 12.4M | 00.00% | Unchanged |
| Frazier Life Sciences Management, L.P. |
| 1.3% | 1.37% | #10 | $59.9M | 9.7M | $53.1M | 9.7M | 00.00% | Unchanged |
| Polar Capital Holdings Plc |
| 0.14% | 0.18% | #31 | $58.8M | 9.5M | $52.1M | 9.5M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #86 | $48.9M | 7.9M | $42.5M | 7.8M | +148,632+1.91% | Add |
| Nantahala Capital Management, LLC |
| 1.43% | 1.48% | #9 | $43.0M | 7.0M | $40.1M | 7.3M | -367,973-5.01% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #80 | $40.4M | 6.6M | $36.6M | 6.7M | -154,336-2.30% | Reduce |
| MARSHALL WACE, LLP |
| 0.03% | 0.02% | #43 | $38.5M | 6.3M | $24.6M | 4.5M | +1.7M+38.60% | Add |
| RTW INVESTMENTS, LP |
| 0.31% | 0.32% | #26 | $36.7M | 6.0M | $32.5M | 6.0M | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.08% | 0.09% | #38 | $26.1M | 4.2M | $23.2M | 4.2M | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.46% | 0.07% | #19 | $24.4M | 4.0M | $3.5M | 635,000 | +3.3M+523.61% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #78 | $23.9M | 3.9M | $19.6M | 3.6M | +277,653+7.72% | Add |
| Spruce Street Capital LP |
| 4.17% | 4.44% | #4 | $21.3M | 3.5M | $18.5M | 3.4M | +69,401+2.05% | Add |
| Rosalind Advisors, Inc. |
| 4.64% | 7.03% | #3 | $19.6M | 3.2M | $17.5M | 3.2M | -25,600-0.80% | Reduce |
| EMERALD ADVISERS, LLC |
| 0.46% | 0.58% | #20 | $19.4M | 3.1M | $18.4M | 3.4M | -222,846-6.61% | Reduce |
| Pictet Asset Management Holding SA |
| 0.02% | 0.01% | #47 | $17.0M | 2.8M | $12.4M | 2.3M | +487,674+21.43% | Add |
| Vestal Point Capital, LP |
| 0.39% | 0.4% | #22 | $16.8M | 2.7M | $14.2M | 2.6M | +119,948+4.61% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #66 | $16.6M | 2.7M | $14.8M | 2.7M | -15,911-0.59% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #54 | $15.5M | 2.5M | $11.5M | 2.1M | +403,116+19.09% | Add |
| Affinity Asset Advisors, LLC |
| 0.7% | 0.71% | #14 | $15.5M | 2.5M | $13.7M | 2.5M | 00.00% | Unchanged |
| EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.51% | 0.63% | #18 | $14.6M | 2.4M | $12.9M | 2.4M | +7,330+0.31% | Add |
| NAN FUNG TRINITY (HK) Ltd |
| 1.12% | 1.1% | #11 | $11.3M | 1.8M | $10.1M | 1.8M | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #107 | $10.1M | 1.6M | $7.5M | 1.4M | +260,361+18.93% | Add |
| ADAR1 Capital Management, LLC |
| 0.4% | 0.47% | #21 | $8.6M | 1.4M | $8.0M | 1.5M | -61,126-4.17% | Reduce |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.87% | 0.8% | #13 | $8.3M | 1.4M | $7.8M | 1.4M | -75,523-5.28% | Reduce |
| ALGERT GLOBAL LLC |
| 0.1% | 0.07% | #36 | $8.2M | 1.3M | $4.7M | 864,614 | +464,645+53.74% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #89 | $8.0M | 1.3M | $6.5M | 1.2M | +112,911+9.49% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #88 | $7.2M | 1.2M | $6.2M | 1.1M | +30,503+2.68% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #76 | $6.4M | 1.0M | $5.5M | 1.0M | +36,259+3.61% | Add |
| Longaeva Partners L.P. |
| 0.14% | 0.26% | #32 | $6.3M | 1.0M | $7.0M | 1.3M | -259,113-20.32% | Reduce |
| BNP Paribas Asset Management Holding S.A. |
| 0.01% | — | #55 | $6.2M | 1.0M | $0 | 0 | +1.0M | New Buy |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 3.8% | 6.19% | #5 | $6.0M | 977,460 | $8.7M | 1.6M | -608,517-38.37% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #75 | $5.3M | 864,956 | $4.6M | 848,391 | +16,565+1.95% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #108 | $5.1M | 829,345 | $3.2M | 580,059 | +249,286+42.98% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.61% | 0.64% | #16 | $4.7M | 756,164 | $4.0M | 739,164 | +17,000+2.30% | Add |
| Swedbank AB |
| <0.01% | <0.01% | #59 | $4.4M | 715,900 | $3.8M | 700,000 | +15,900+2.27% | Add |
| VOYA INVESTMENT MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $4.3M | 692,211 | $4.1M | 756,774 | -64,563-8.53% | Reduce |
| F/m Investments LLC |
| 0.21% | 0.24% | #28 | $4.1M | 658,354 | $3.6M | 651,024 | +7,330+1.13% | Add |
| Sio Capital Management, LLC |
| 0.63% | 0.48% | #15 | $3.8M | 617,675 | $3.4M | 613,888 | +3,787+0.62% | Add |
| KVP Capital Advisors, LP |
| 2.74% | 2.47% | #7 | $3.7M | 605,280 | $3.3M | 605,280 | 00.00% | Unchanged |
| Integral Health Asset Management, LLC |
| 0.15% | 0.16% | #30 | $3.7M | 600,000 | $3.3M | 600,000 | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #129 | $3.2M | 520,356 | $3.2M | 588,199 | -67,843-11.53% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #111 | $3.2M | 513,026 | $3.3M | 596,715 | -83,689-14.02% | Reduce |
| MOODY ALDRICH PARTNERS LLC |
| 0.53% | 0.6% | #17 | $3.0M | 482,793 | $3.4M | 614,279 | -131,486-21.40% | Reduce |
| Jupiter Topco LLC |
| <0.01% | — | #81 | $2.9M | 466,611 | $0 | 0 | +466,611 | New Buy |
| Y-Intercept (Hong Kong) Ltd |
| 0.05% | — | #40 | $2.5M | 410,609 | $0 | 0 | +410,609 | New Buy |
