| Nextech Invest Ltd. |
| 3.7% | 6.39% | #4 | $77.6M | 7.2M | $90.8M | 7.2M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #93 | $73.9M | 6.8M | $75.8M | 6.0M | +839,421+14.03% | Add |
| EcoR1 Capital, LLC |
| 3.54% | 3.62% | #5 | $72.9M | 6.7M | $85.2M | 6.7M | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #60 | $71.7M | 6.6M | $68.3M | 5.4M | +1.2M+22.83% | Add |
| VIKING GLOBAL INVESTORS LP |
| 0.16% | 0.21% | #30 | $55.5M | 5.1M | $73.8M | 5.8M | -697,771-11.98% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #86 | $53.0M | 4.9M | $46.9M | 3.7M | +1.2M+32.19% | Add |
| SR ONE CAPITAL MANAGEMENT, LP |
| 4.81% | 6.39% | #3 | $50.0M | 4.6M | $58.5M | 4.5M | +100,455+2.22% | Add |
| Venrock Adviser, LLC |
| 1.42% | 2.04% | #15 | $46.8M | 4.3M | $54.7M | 4.3M | 00.00% | Unchanged |
| NEA Management Company, LLC |
| 2.81% | 2.97% | #7 | $44.6M | 4.1M | $52.2M | 4.1M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #98 | $42.8M | 4.0M | $46.7M | 3.7M | +264,162+7.16% | Add |
| AIHC Capital Management Ltd |
| 39.77% | 26.04% | #2 | $41.5M | 3.8M | $31.2M | 2.5M | +1.4M+55.66% | Add |
| ALKEON CAPITAL MANAGEMENT LLC |
| 0.05% | 0.1% | #41 | $40.5M | 3.7M | $57.1M | 4.5M | -765,000-16.98% | Reduce |
| Column Group LLC |
| 43.53% | 44.55% | #1 | $38.3M | 3.5M | $44.9M | 3.5M | 00.00% | Unchanged |
| Siren, L.L.C. |
| 0.66% | 1.05% | #21 | $32.5M | 3.0M | $38.0M | 3.0M | 00.00% | Unchanged |
| FMR LLC |
| <0.01% | <0.01% | #91 | $28.5M | 2.6M | $30.8M | 2.4M | +201,395+8.27% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #68 | $28.4M | 2.6M | $30.8M | 2.4M | +188,558+7.75% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #75 | $26.6M | 2.5M | $18.7M | 1.5M | +976,084+66.14% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #92 | $22.6M | 2.1M | $23.3M | 1.8M | +251,288+13.67% | Add |
| First Turn Management, LLC |
| 2.34% | 2.86% | #10 | $21.8M | 2.0M | $25.6M | 2.0M | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.41% | 0.68% | #24 | $21.8M | 2.0M | $34.1M | 2.7M | -678,929-25.20% | Reduce |
| Integral Health Asset Management, LLC |
| 0.81% | 0.85% | #20 | $20.6M | 1.9M | $17.7M | 1.4M | +500,000+35.71% | Add |
| MPM BioImpact LLC |
| 1.24% | 1.77% | #16 | $20.4M | 1.9M | $22.9M | 1.8M | +78,217+4.34% | Add |
| Vivo Capital, LLC |
| 1.83% | 1.95% | #12 | $20.0M | 1.8M | $23.4M | 1.8M | 00.00% | Unchanged |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #66 | $19.5M | 1.8M | $18.6M | 1.5M | +330,109+22.44% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #64 | $19.5M | 1.8M | $18.4M | 1.5M | +344,542+23.72% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #95 | $19.4M | 1.8M | $8.9M | 745,528 | +1.0M+140.64% | Add |
| D. E. Shaw & Co., Inc. |
| 0.01% | <0.01% | #58 | $17.1M | 1.6M | $562,421 | 44,390 | +1.5M+3,459.85% | Add |
| Woodline Partners LP |
| 0.04% | 0.06% | #43 | $13.5M | 1.2M | $15.8M | 1.2M | 00.00% | Unchanged |
| ALGERT GLOBAL LLC |
| 0.16% | 0.03% | #31 | $13.2M | 1.2M | $1.7M | 136,350 | +1.1M+791.30% | Add |
| BRAIDWELL LP |
| 0.49% | 0.48% | #23 | $13.2M | 1.2M | $14.3M | 1.1M | +86,500+7.67% | Add |
| Candriam S.C.A. |
| 0.06% | — | #40 | $12.8M | 1.2M | $0 | 0 | +1.2M | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #105 | $11.7M | 1.1M | $13.2M | 1.0M | +34,896+3.35% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.01% | #48 | $11.4M | 1.1M | $4.4M | 344,315 | +707,588+205.51% | Add |
| Defilade Capital Management, L.P. |
| 1.52% | 1.5% | #14 | $11.3M | 1.0M | $10.7M | 842,928 | +204,762+24.29% | Add |
| Euclidean Capital LLC |
| 2.44% | 3.2% | #9 | $10.7M | 989,410 | $12.5M | 989,410 | 00.00% | Unchanged |
| ROYCE & ASSOCIATES LP |
| 0.09% | 0.15% | #37 | $10.6M | 979,664 | $15.3M | 1.2M | -227,559-18.85% | Reduce |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.14% | 0.2% | #32 | $10.3M | 954,768 | $12.1M | 953,451 | +1,317+0.14% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 1.21% | 1.08% | #17 | $9.2M | 852,983 | $6.8M | 537,628 | +315,355+58.66% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #96 | $8.7M | 806,304 | $9.0M | 710,861 | +95,443+13.43% | Add |
| Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #59 | $8.6M | 794,542 | $10.9M | 859,491 | -64,949-7.56% | Reduce |
| Jones Hill Capital LP |
| 1.72% | — | #13 | $8.1M | 747,313 | $0 | 0 | +747,313 | New Buy |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.83% | 1.42% | #19 | $8.0M | 738,873 | $13.9M | 1.1M | -361,137-32.83% | Reduce |
| NEXTBio Capital Management LP |
| 3.52% | 3.08% | #6 | $7.6M | 706,124 | $6.6M | 523,619 | +182,505+34.85% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #72 | $7.6M | 697,694 | $430,932 | 34,012 | +663,682+1,951.32% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #97 | $7.3M | 677,823 | $7.7M | 605,037 | +72,786+12.03% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #126 | $6.8M | 628,682 | $7.2M | 570,691 | +57,991+10.16% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #62 | $6.5M | 603,664 | $0 | 0 | +603,664 | New Buy |
| ArrowMark Colorado Holdings LLC |
| 0.26% | 0.32% | #27 | $6.3M | 582,875 | $12.2M | 960,517 | -377,642-39.32% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #90 | $6.1M | 566,038 | $6.4M | 507,294 | +58,744+11.58% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | 0.02% | #55 | $5.6M | 518,460 | $6.6M | 522,061 | -3,601-0.69% | Reduce |
