| T. Rowe Price Investment Management, Inc. |
| 0.15% | 0.15% | #16 | $226.6M | 22.4M | $213.1M | 21.7M | +712,884+3.29% | Add |
| RTW INVESTMENTS, LP |
| 1.12% | 1.26% | #6 | $131.1M | 12.9M | $126.6M | 12.9M | +76,836+0.60% | Add |
| MONTANOVA CAPITAL, LLC |
| 2.07% | 2.81% | #1 | $113.4M | 11.2M | $110.1M | 11.2M | 00.00% | Unchanged |
| PERCEPTIVE ADVISORS LLC |
| 1.58% | 2% | #4 | $105.2M | 10.4M | $102.2M | 10.4M | 00.00% | Unchanged |
| BAKER BROS. ADVISORS LP |
| 0.48% | 0.62% | #9 | $96.3M | 9.5M | $107.4M | 10.9M | -1.4M-12.90% | Reduce |
| Jefferies Financial Group Inc. |
| 0.43% | 0.34% | #10 | $65.9M | 6.5M | $49.8M | 5.1M | +1.4M+28.60% | Add |
| Vestal Point Capital, LP |
| 1.46% | 1.7% | #5 | $62.6M | 6.2M | $60.8M | 6.2M | 00.00% | Unchanged |
| Sofinnova Investments, Inc. |
| 1.92% | 1.36% | #2 | $37.2M | 3.7M | $35.7M | 3.6M | +38,892+1.07% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #50 | $22.1M | 2.2M | $18.8M | 2.2M | -18,827-0.85% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #47 | $18.5M | 1.8M | $18.4M | 1.9M | -45,306-2.42% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #44 | $16.7M | 1.6M | $15.4M | 1.6M | +85,960+5.50% | Add |
| Point72 Asset Management, L.P. |
| 0.02% | 0.02% | #27 | $14.7M | 1.4M | $14.7M | 1.5M | -44,203-2.96% | Reduce |
| Woodline Partners LP |
| 0.03% | 0.04% | #26 | $9.1M | 900,736 | $9.8M | 1.0M | -99,861-9.98% | Reduce |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.95% | 1.09% | #7 | $7.3M | 720,057 | $6.8M | 696,105 | +23,952+3.44% | Add |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO |
| 0.82% | 1% | #8 | $7.1M | 697,431 | $6.9M | 697,431 | 00.00% | Unchanged |
| Aberdeen Group plc |
| 0.01% | 0.01% | #29 | $6.6M | 653,604 | $8.1M | 820,717 | -167,113-20.36% | Reduce |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #35 | $5.3M | 523,217 | $3.6M | 366,772 | +156,445+42.65% | Add |
| Boxer Capital Management, LLC |
| 0.36% | — | #11 | $4.8M | 475,000 | $0 | 0 | +475,000 | New Buy |
| TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #39 | $4.6M | 449,348 | $4.6M | 470,444 | -21,096-4.48% | Reduce |
| WASATCH ADVISORS LP |
| 0.03% | 0.03% | #24 | $4.5M | 441,510 | $4.6M | 464,823 | -23,313-5.02% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #64 | $4.3M | 419,698 | $4.5M | 456,998 | -37,300-8.16% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #56 | $4.2M | 410,712 | $6.4M | 652,170 | -241,458-37.02% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.01% | #34 | $4.1M | 401,643 | $9.7M | 982,864 | -581,221-59.14% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #58 | $3.9M | 384,171 | $2.1M | 215,978 | +168,193+77.88% | Add |
| SECTORAL ASSET MANAGEMENT INC |
| 1.59% | 0.57% | #3 | $2.3M | 224,928 | $692,687 | 66,830 | +158,098+236.57% | Add |
| Atom Investors LP |
| 0.19% | 0.18% | #14 | $2.2M | 216,365 | $2.5M | 254,140 | -37,775-14.86% | Reduce |
| MOORE CAPITAL MANAGEMENT, LP |
| 0.03% | — | #25 | $2.0M | 192,770 | $0 | 0 | +192,770 | New Buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
| <0.01% | <0.01% | #48 | $1.9M | 197,300 | $3.7M | 402,352 | -205,052-50.96% | Reduce |
| Tidal Investments LLC |
| <0.01% | <0.01% | #43 | $1.7M | 171,499 | $1.7M | 170,389 | +1,110+0.65% | Add |
| Burkehill Global Management, LP |
| 0.05% | 0.07% | #20 | $1.5M | 150,000 | $1.5M | 150,000 | 00.00% | Unchanged |
| SummitTX Capital, L.P. |
| 0.04% | 0.05% | #23 | $1.5M | 146,351 | $1.5M | 151,112 | -4,761-3.15% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #54 | $1.5M | 145,010 | $2.1M | 215,721 | -70,711-32.78% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #68 | $1.4M | 141,400 | $1.3M | 134,277 | +7,123+5.30% | Add |
| ALPS ADVISORS INC |
| 0.01% | 0.01% | #32 | $1.4M | 135,599 | $1.1M | 109,138 | +26,461+24.25% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #69 | $1.3M | 137,074 | $1.3M | 140,465 | -3,391-2.41% | Reduce |
| MYDA Advisors LLC |
| 0.18% | 0.19% | #15 | $1.2M | 120,000 | $1.2M | 120,000 | 00.00% | Unchanged |
| DAFNA Capital Management LLC |
| 0.23% | 0.51% | #12 | $1.2M | 116,960 | $2.2M | 225,860 | -108,900-48.22% | Reduce |
| Jump Financial, LLC |
| 0.01% | 0.01% | #30 | $1.1M | 106,046 | $475,656 | 48,339 | +57,707+119.38% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #66 | $1.1M | 104,548 | $186,399 | 18,943 | +85,605+451.91% | Add |
| SG Americas Securities, LLC |
| <0.01% | <0.01% | #55 | $884,116 | 87,277 | $978,000 | 99,441 | -12,164-12.23% | Reduce |
| CITIGROUP INC |
| <0.01% | <0.01% | #60 | $678,031 | 66,933 | $599,394 | 60,914 | +6,019+9.88% | Add |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #52 | $672,976 | 66,434 | $659,752 | 67,048 | -614-0.92% | Reduce |
| D. E. Shaw & Co., Inc. |
| <0.01% | — | #59 | $599,301 | 59,161 | $0 | 0 | +59,161 | New Buy |
| MACQUARIE GROUP LTD |
| <0.01% | — | #45 | $541,955 | 53,500 | $0 | 0 | +53,500 | New Buy |
| Engineers Gate Manager LP |
| 0.01% | <0.01% | #31 | $515,475 | 50,886 | $396,040 | 40,248 | +10,638+26.43% | Add |
| Vanguard Personalized Indexing Management, LLC |
| <0.01% | <0.01% | #38 | $500,067 | 49,365 | $441,718 | 44,890 | +4,475+9.97% | Add |
| Ikarian Capital, LLC |
| 0.05% | 0.04% | #21 | $492,003 | 48,569 | $477,919 | 48,569 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | <0.01% | #65 | $468,665 | 46,265 | $636,195 | 64,654 | -18,389-28.44% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #75 | $442,245 | 43,657 | $249,877 | 25,394 | +18,263+71.92% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #61 | $438,599 | 43,297 | $1.0M | 104,023 | -60,726-58.38% | Reduce |
