| FEDERATED HERMES, INC. |
| 0.1% | 0.06% | #17 | $67.6M | 13.0M | $39.6M | 13.0M | 00.00% | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.43% | 0.3% | #8 | $49.1M | 9.4M | $28.0M | 9.2M | +265,039+2.89% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #73 | $40.1M | 7.7M | $19.3M | 6.3M | +1.4M+22.25% | Add |
| Opaleye Management Inc. |
| 2.97% | 2.53% | #2 | $32.8M | 6.3M | $19.2M | 6.3M | 00.00% | Unchanged |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.02% | #22 | $24.2M | 4.7M | $15.4M | 5.0M | -386,382-7.65% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #78 | $19.9M | 3.8M | $10.7M | 3.5M | +313,747+8.91% | Add |
| Siren, L.L.C. |
| 0.35% | 0.28% | #9 | $17.3M | 3.3M | $10.2M | 3.3M | 00.00% | Unchanged |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.05% | <0.01% | #20 | $13.3M | 2.6M | $672,241 | 220,407 | +2.3M+1,062.24% | Add |
| JENNISON ASSOCIATES LLC |
| 0.01% | 0.01% | #33 | $12.8M | 2.5M | $10.5M | 3.4M | -979,573-28.49% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #71 | $11.3M | 2.2M | $6.0M | 2.0M | +205,795+10.48% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #91 | $9.6M | 1.9M | $5.4M | 1.8M | +78,287+4.42% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #38 | $9.6M | 1.8M | $5.4M | 1.8M | +73,377+4.16% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #75 | $8.4M | 1.6M | $3.2M | 337,920 | +1.3M+379.04% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #70 | $8.3M | 1.6M | $3.3M | 1.1M | +501,211+46.09% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $7.2M | 1.4M | $9.1M | 3.0M | -1.6M-53.69% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #72 | $6.8M | 1.3M | $1.8M | 602,296 | +714,486+118.63% | Add |
| Squadron Capital Management LLC |
| 2.1% | — | #4 | $6.8M | 1.3M | $0 | 0 | +1.3M | New Buy |
| Nuveen, LLC |
| <0.01% | <0.01% | #49 | $6.7M | 1.3M | $297,942 | 97,686 | +1.2M+1,225.89% | Add |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.11% | 0.08% | #13 | $6.4M | 1.2M | $3.8M | 1.2M | -14,420-1.17% | Reduce |
| Blackstone Inc. |
| 0.02% | — | #27 | $5.6M | 1.1M | $0 | 0 | +1.1M | New Buy |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #44 | $5.2M | 1.0M | $2.4M | 796,696 | +211,266+26.52% | Add |
| Affinity Asset Advisors, LLC |
| 0.24% | 0.24% | #11 | $5.2M | 1.0M | $4.7M | 1.5M | -547,641-35.39% | Reduce |
| GREAT POINT PARTNERS LLC |
| 0.94% | 0.67% | #6 | $4.9M | 951,809 | $2.9M | 951,809 | 00.00% | Unchanged |
| Ikarian Capital, LLC |
| 0.52% | <0.01% | #7 | $4.9M | 935,012 | $50,261 | 16,479 | +918,533+5,573.96% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #63 | $4.6M | 890,733 | $1.6M | 530,229 | +360,504+67.99% | Add |
| 22NW, LP |
| 4.08% | 1.97% | #1 | $4.3M | 820,653 | $2.5M | 820,653 | 00.00% | Unchanged |
| Velan Capital Investment Management LP |
| 2.38% | 1.43% | #3 | $3.9M | 750,000 | $2.3M | 750,000 | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #94 | $3.8M | 730,332 | $9.1M | 3.0M | -2.2M-75.41% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #76 | $3.8M | 725,271 | $1.9M | 632,821 | +92,450+14.61% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #74 | $3.8M | 723,588 | $1.9M | 638,384 | +85,204+13.35% | Add |
| Woodline Partners LP |
| 0.01% | 0.01% | #30 | $3.2M | 611,797 | $1.9M | 611,797 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #68 | $3.0M | 571,037 | $1.8M | 599,814 | -28,777-4.80% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #59 | $2.7M | 517,234 | $4.6M | 1.5M | -1.0M-65.92% | Reduce |
| J. Goldman & Co LP |
| 0.07% | 0.05% | #18 | $2.6M | 500,405 | $1.8M | 585,892 | -85,487-14.59% | Reduce |
| Integral Health Asset Management, LLC |
| 0.1% | 0.29% | #14 | $2.6M | 500,000 | $6.1M | 2.0M | -1.5M-75.00% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #86 | $2.6M | 496,033 | $5.9M | 1.9M | -1.4M-74.41% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #47 | $2.2M | 431,073 | $2.5M | 830,588 | -399,515-48.10% | Reduce |
| Vestal Point Capital, LP |
| 0.05% | — | #21 | $2.0M | 382,999 | $0 | 0 | +382,999 | New Buy |
| Knott David M Jr |
| 1.03% | 0.68% | #5 | $1.9M | 370,000 | $1.1M | 370,000 | 00.00% | Unchanged |
| XTX Topco Ltd |
| 0.02% | 0.02% | #24 | $1.8M | 353,670 | $893,122 | 292,827 | +60,843+20.78% | Add |
| Jupiter Topco LLC |
| <0.01% | — | #66 | $1.7M | 332,349 | $0 | 0 | +332,349 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #98 | $1.7M | 322,590 | $604,217 | 198,104 | +124,486+62.84% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.01% | — | #32 | $1.5M | 289,519 | $0 | 0 | +289,519 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.02% | — | #26 | $1.5M | 286,955 | $0 | 0 | +286,955 | New Buy |
| Susquehanna Portfolio Strategies, LLC |
| 0.02% | 0.01% | #25 | $1.5M | 279,641 | $348,703 | 114,329 | +165,312+144.59% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #109 | $1.4M | 263,879 | $1.7M | 565,363 | -301,484-53.33% | Reduce |
| Schonfeld Strategic Advisors LLC |
| <0.01% | — | #36 | $1.4M | 263,746 | $0 | 0 | +263,746 | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #128 | $1.1M | 216,117 | $174,966 | 57,366 | +158,751+276.73% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #100 | $1.1M | 212,270 | $578,828 | 189,779 | +22,491+11.85% | Add |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #62 | $1.1M | 210,044 | $140,638 | 46,111 | +163,933+355.52% | Add |
