| EcoR1 Capital, LLC |
| 3.11% | — | #3 | $63.9M | 3.2M | $0 | 0 | +3.2M | New Buy |
| TCG Crossover Management, LLC |
| 1.4% | — | #8 | $58.3M | 2.9M | $0 | 0 | +2.9M | New Buy |
| FMR LLC |
| <0.01% | — | #49 | $41.3M | 2.1M | $0 | 0 | +2.1M | New Buy |
| Affinity Asset Advisors, LLC |
| 1.85% | — | #5 | $40.9M | 2.0M | $0 | 0 | +2.0M | New Buy |
| BlackRock, Inc. |
| <0.01% | — | #72 | $39.5M | 2.0M | $0 | 0 | +2.0M | New Buy |
| Trails Edge Capital Partners, LP |
| 4.84% | — | #2 | $30.5M | 1.5M | $0 | 0 | +1.5M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #71 | $29.2M | 1.5M | $0 | 0 | +1.5M | New Buy |
| Jupiter Topco LLC |
| 0.01% | — | #35 | $22.0M | 1.1M | $0 | 0 | +1.1M | New Buy |
| Vestal Point Capital, LP |
| 0.48% | — | #12 | $20.4M | 1.0M | $0 | 0 | +1.0M | New Buy |
| Woodline Partners LP |
| 0.06% | — | #23 | $18.5M | 917,176 | $0 | 0 | +917,176 | New Buy |
| Sanofi |
| 3.1% | — | #4 | $16.5M | 821,917 | $0 | 0 | +821,917 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #64 | $15.7M | 781,534 | $0 | 0 | +781,534 | New Buy |
| 683 Capital Management, LLC |
| 0.74% | — | #9 | $15.1M | 750,000 | $0 | 0 | +750,000 | New Buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | — | #27 | $14.7M | 729,000 | $0 | 0 | +729,000 | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | — | #29 | $14.4M | 714,948 | $0 | 0 | +714,948 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #68 | $14.1M | 702,087 | $0 | 0 | +702,087 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | — | #63 | $13.0M | 647,962 | $0 | 0 | +647,962 | New Buy |
| STEMPOINT CAPITAL LP |
| 1.78% | — | #6 | $12.5M | 622,723 | $0 | 0 | +622,723 | New Buy |
| Palo Alto Investors LP |
| 1.77% | — | #7 | $12.1M | 603,489 | $0 | 0 | +603,489 | New Buy |
| Sofinnova Investments, Inc. |
| 0.59% | — | #10 | $11.4M | 565,199 | $0 | 0 | +565,199 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #75 | $11.0M | 546,992 | $0 | 0 | +546,992 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | — | #61 | $9.8M | 487,213 | $0 | 0 | +487,213 | New Buy |
| Point72 Asset Management, L.P. |
| 0.01% | — | #34 | $8.2M | 408,330 | $0 | 0 | +408,330 | New Buy |
| UBS Group AG |
| <0.01% | — | #66 | $6.3M | 310,886 | $0 | 0 | +310,886 | New Buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #46 | $6.0M | 299,500 | $0 | 0 | +299,500 | New Buy |
| FEDERATED HERMES, INC. |
| 0.01% | — | #36 | $5.8M | 290,000 | $0 | 0 | +290,000 | New Buy |
| Ally Bridge Group (NY) LLC |
| 5.06% | — | #1 | $5.7M | 284,287 | $0 | 0 | +284,287 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #69 | $5.2M | 256,873 | $0 | 0 | +256,873 | New Buy |
| Nantahala Capital Management, LLC |
| 0.17% | — | #17 | $5.0M | 250,000 | $0 | 0 | +250,000 | New Buy |
| Granahan Investment Management, LLC |
| 0.17% | — | #16 | $4.8M | 238,304 | $0 | 0 | +238,304 | New Buy |
| APIS CAPITAL ADVISORS, LLC |
| 0.44% | — | #13 | $4.5M | 226,000 | $0 | 0 | +226,000 | New Buy |
| FRED ALGER MANAGEMENT, LLC |
| 0.01% | — | #30 | $4.4M | 218,400 | $0 | 0 | +218,400 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | — | #78 | $4.0M | 201,096 | $0 | 0 | +201,096 | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #67 | $3.9M | 193,183 | $0 | 0 | +193,183 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #62 | $3.8M | 191,220 | $0 | 0 | +191,220 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | — | #81 | $3.4M | 168,790 | $0 | 0 | +168,790 | New Buy |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | — | #40 | $3.3M | 164,793 | $0 | 0 | +164,793 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | — | #47 | $3.3M | 163,851 | $0 | 0 | +163,851 | New Buy |
| D. E. Shaw & Co., Inc. |
| <0.01% | — | #54 | $2.6M | 128,130 | $0 | 0 | +128,130 | New Buy |
| Rockefeller Capital Management L.P. |
| <0.01% | — | #42 | $2.4M | 116,939 | $0 | 0 | +116,939 | New Buy |
| Ensign Peak Advisors, Inc |
| <0.01% | — | #41 | $2.3M | 115,978 | $0 | 0 | +115,978 | New Buy |
| Jain Global LLC |
| 0.01% | — | #37 | $2.0M | 98,956 | $0 | 0 | +98,956 | New Buy |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| <0.01% | — | #44 | $1.9M | 93,732 | $0 | 0 | +93,732 | New Buy |
| Financial Enhancement Group LLC |
| 0.18% | — | #15 | $1.5M | 74,450 | $0 | 0 | +74,450 | New Buy |
| ADAR1 Capital Management, LLC |
| 0.07% | — | #22 | $1.4M | 71,910 | $0 | 0 | +71,910 | New Buy |
| Invesco Ltd. |
| <0.01% | — | #113 | $1.4M | 71,014 | $0 | 0 | +71,014 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #99 | $1.4M | 69,813 | $0 | 0 | +69,813 | New Buy |
| NORGES BANK |
| <0.01% | — | #111 | $1.4M | 69,100 | $0 | 0 | +69,100 | New Buy |
| Opaleye Management Inc. |
| 0.12% | — | #18 | $1.3M | 65,000 | $0 | 0 | +65,000 | New Buy |
| Quantinno Capital Management LP |
| <0.01% | — | #50 | $1.3M | 62,494 | $0 | 0 | +62,494 | New Buy |
