| Frazier Life Sciences Management, L.P. |
| 2.95% | 3.56% | #5 | $135.3M | 12.5M | $138.5M | 12.5M | 00.00% | Unchanged |
| Medicxi Ventures Management (Jersey) Ltd |
| 45.65% | 8.45% | #1 | $81.0M | 7.5M | $82.9M | 7.5M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #78 | $49.1M | 4.5M | $45.1M | 4.1M | +463,133+11.40% | Add |
| Invesco Ltd. |
| <0.01% | 0.01% | #57 | $43.7M | 4.0M | $48.0M | 4.3M | -292,329-6.76% | Reduce |
| Carlyle Group Inc. |
| 0.38% | 0.37% | #9 | $37.9M | 3.5M | $38.8M | 3.5M | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.02% | #40 | $36.6M | 3.4M | $44.7M | 4.0M | -647,075-16.08% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #81 | $28.8M | 2.7M | $28.7M | 2.6M | +73,308+2.84% | Add |
| GW&K Investment Management, LLC |
| 0.18% | 0.14% | #16 | $23.5M | 2.2M | $15.8M | 1.4M | +745,729+52.48% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #53 | $21.4M | 2.0M | $11.0M | 994,504 | +976,324+98.17% | Add |
| NEA Management Company, LLC |
| 1.34% | 1.24% | #7 | $21.3M | 2.0M | $21.8M | 2.0M | 00.00% | Unchanged |
| 683 Capital Management, LLC |
| 0.99% | 1.07% | #8 | $20.1M | 1.9M | $20.6M | 1.9M | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #63 | $19.3M | 1.8M | $7.0M | 626,196 | +1.2M+183.94% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #88 | $17.2M | 1.6M | $15.4M | 1.4M | +199,433+14.38% | Add |
| Catalys Pacific, LLC |
| 7.06% | 7.19% | #2 | $16.2M | 1.5M | $16.6M | 1.5M | 00.00% | Unchanged |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.02% | 0.02% | #31 | $15.9M | 1.5M | $13.4M | 1.2M | +257,369+21.35% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #76 | $14.3M | 1.3M | $14.8M | 1.3M | -12,358-0.93% | Reduce |
| WASATCH ADVISORS LP |
| 0.09% | 0.1% | #22 | $14.2M | 1.3M | $14.9M | 1.3M | -33,669-2.51% | Reduce |
| Ensign Peak Advisors, Inc |
| 0.02% | 0.03% | #36 | $11.4M | 1.1M | $18.1M | 1.6M | -575,893-35.38% | Reduce |
| Propel Bio Management, LLC |
| 5.96% | 5.9% | #3 | $11.4M | 1.1M | $9.4M | 841,272 | +209,086+24.85% | Add |
| Point72 Asset Management, L.P. |
| 0.01% | — | #42 | $11.1M | 1.0M | $0 | 0 | +1.0M | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #100 | $8.6M | 796,631 | $7.4M | 666,029 | +130,602+19.61% | Add |
| SummitTX Capital, L.P. |
| 0.22% | 0.35% | #15 | $8.6M | 789,550 | $11.1M | 995,885 | -206,335-20.72% | Reduce |
| HSBC HOLDINGS PLC |
| <0.01% | — | #59 | $7.7M | 709,695 | $0 | 0 | +709,695 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #71 | $7.6M | 696,801 | $10.2M | 918,158 | -221,357-24.11% | Reduce |
| MARSHALL WACE, LLP |
| 0.01% | 0.01% | #50 | $7.2M | 666,090 | $9.6M | 860,692 | -194,602-22.61% | Reduce |
| EcoR1 Capital, LLC |
| 0.33% | 0.29% | #12 | $6.8M | 625,000 | $6.9M | 625,000 | 00.00% | Unchanged |
| PERCEPTIVE ADVISORS LLC |
| 0.09% | 0.2% | #23 | $5.8M | 532,000 | $10.3M | 925,000 | -393,000-42.49% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #55 | $5.6M | 519,076 | $5.4M | 482,136 | +36,940+7.66% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #84 | $5.0M | 458,301 | $4.6M | 414,956 | +43,345+10.45% | Add |
| StepStone Group LP |
| 2.05% | 2.26% | #6 | $4.7M | 422,085 | $4.7M | 422,085 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #82 | $4.5M | 419,094 | $4.5M | 409,015 | +10,079+2.46% | Add |
| Woodline Partners LP |
| 0.01% | 0.02% | #41 | $4.0M | 369,052 | $4.1M | 369,052 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #73 | $3.8M | 354,573 | $3.8M | 338,713 | +15,860+4.68% | Add |
| Hennion & Walsh Asset Management, Inc. |
| 0.1% | 0.05% | #21 | $3.6M | 327,278 | $1.6M | 145,932 | +181,346+124.27% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #80 | $3.2M | 293,979 | $2.8M | 254,219 | +39,760+15.64% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #113 | $3.1M | 289,906 | $979,902 | 88,200 | +201,706+228.69% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #124 | $3.0M | 275,251 | $3.0M | 287,430 | -12,179-4.24% | Reduce |
| Simplify Asset Management Inc. |
| 0.04% | 0.04% | #26 | $2.7M | 249,267 | $2.9M | 262,386 | -13,119-5.00% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #118 | $2.7M | 248,325 | $5.1M | 458,079 | -209,754-45.79% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | 0.01% | #58 | $2.5M | 226,400 | $3.4M | 305,800 | -79,400-25.96% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #110 | $2.2M | 204,573 | $4.0M | 360,371 | -155,798-43.23% | Reduce |
| NewEdge Advisors, LLC |
| 0.01% | 0.01% | #49 | $2.2M | 203,962 | $2.0M | 183,000 | +20,962+11.45% | Add |
| Avidity Partners Management LP |
| 0.35% | 0.56% | #11 | $2.2M | 200,000 | $2.8M | 249,390 | -49,390-19.80% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #133 | $2.2M | 199,909 | $3.0M | 255,573 | -55,664-21.78% | Reduce |
| Jump Financial, LLC |
| 0.02% | <0.01% | #38 | $2.1M | 191,866 | $293,804 | 26,445 | +165,421+625.53% | Add |
| Opaleye Management Inc. |
| 0.18% | — | #17 | $2.0M | 185,589 | $0 | 0 | +185,589 | New Buy |
| Trexquant Investment LP |
| 0.01% | 0.02% | #43 | $1.9M | 173,884 | $3.3M | 293,305 | -119,421-40.72% | Reduce |
| Jones Hill Capital LP |
| 0.37% | — | #10 | $1.8M | 161,486 | $0 | 0 | +161,486 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #111 | $1.7M | 152,313 | $1.4M | 124,018 | +28,295+22.82% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #112 | $1.6M | 152,002 | $512,315 | 46,113 | +105,889+229.63% | Add |
