| MPM BioImpact LLC |
| 9.5% | 6.68% | #2 | $155.9M | 4.8M | $86.5M | 4.8M | 00.00% | Unchanged |
| EcoR1 Capital, LLC |
| 7.56% | 3.66% | #3 | $155.5M | 4.8M | $86.3M | 4.8M | 00.00% | Unchanged |
| Blue Owl Capital Holdings LP |
| 14.41% | 15.2% | #1 | $99.0M | 3.1M | $56.6M | 3.2M | -91,129-2.88% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #46 | $73.4M | 2.3M | $37.8M | 2.1M | +166,231+7.87% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.04% | 0.03% | #17 | $66.1M | 2.1M | $38.0M | 2.1M | -72,365-3.41% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | 0.01% | #26 | $63.4M | 2.0M | $41.5M | 2.3M | -350,800-15.14% | Reduce |
| RTW INVESTMENTS, LP |
| 0.44% | 0.28% | #9 | $51.3M | 1.6M | $28.5M | 1.6M | 00.00% | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.37% | 0.28% | #10 | $42.4M | 1.3M | $26.9M | 1.5M | -188,679-12.55% | Reduce |
| Jupiter Topco LLC |
| 0.02% | — | #24 | $42.4M | 1.3M | $0 | 0 | +1.3M | New Buy |
| BAKER BROS. ADVISORS LP |
| 0.16% | 0.1% | #13 | $32.1M | 996,351 | $17.8M | 996,351 | 00.00% | Unchanged |
| Octagon Capital Advisors LP |
| 2.78% | 1.9% | #5 | $31.0M | 960,847 | $17.2M | 960,847 | 00.00% | Unchanged |
| Merck & Co., Inc. |
| 5.83% | 4.88% | #4 | $30.7M | 952,844 | $17.0M | 952,844 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #57 | $26.3M | 817,075 | $14.9M | 833,913 | -16,838-2.02% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #37 | $24.6M | 763,499 | $28.0M | 1.6M | -800,697-51.19% | Reduce |
| TCG Crossover Management, LLC |
| 0.54% | — | #8 | $22.5M | 696,560 | $0 | 0 | +696,560 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #50 | $16.8M | 520,737 | $8.8M | 491,936 | +28,801+5.85% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.22% | 0.15% | #12 | $16.3M | 507,000 | $9.1M | 507,000 | 00.00% | Unchanged |
| Avidity Partners Management LP |
| 2.5% | 1.7% | #6 | $15.6M | 484,200 | $8.4M | 468,566 | +15,634+3.34% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #60 | $15.6M | 484,010 | $7.7M | 428,253 | +55,757+13.02% | Add |
| Alyeska Investment Group, L.P. |
| 0.02% | 0.01% | #22 | $9.3M | 290,000 | $5.2M | 290,000 | 00.00% | Unchanged |
| FMR LLC |
| <0.01% | <0.01% | #65 | $9.2M | 285,631 | $6.9M | 386,379 | -100,748-26.07% | Reduce |
| ArrowMark Colorado Holdings LLC |
| 0.33% | 0.16% | #11 | $7.9M | 245,872 | $5.9M | 329,471 | -83,599-25.37% | Reduce |
| a16z Capital Management, L.L.C. |
| 0.59% | 0.58% | #7 | $7.4M | 415,000 | $7.4M | 415,000 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #54 | $5.8M | 180,575 | $2.7M | 149,476 | +31,099+20.81% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #53 | $5.4M | 166,842 | $2.9M | 162,017 | +4,825+2.98% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #49 | $4.9M | 151,696 | $173,963 | 9,724 | +141,972+1,460.02% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #71 | $4.7M | 145,220 | $2.2M | 120,322 | +24,898+20.69% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #48 | $4.3M | 133,834 | $2.3M | 127,395 | +6,439+5.05% | Add |
| TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #36 | $3.4M | 105,902 | $1.8M | 100,962 | +4,940+4.89% | Add |
| Woodline Partners LP |
| 0.01% | 0.01% | #28 | $3.2M | 100,000 | $1.8M | 100,000 | 00.00% | Unchanged |
| SOROS FUND MANAGEMENT LLC |
| 0.04% | 0.02% | #18 | $3.2M | 100,000 | $1.8M | 100,000 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #64 | $3.2M | 99,960 | $6.3M | 353,263 | -253,303-71.70% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #33 | $3.1M | 95,400 | $0 | 0 | +95,400 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #75 | $2.3M | 72,835 | $1.3M | 69,926 | +2,909+4.16% | Add |
| POLEN CAPITAL MANAGEMENT LLC |
| 0.02% | — | #23 | $2.0M | 63,514 | $0 | 0 | +63,514 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #82 | $2.0M | 62,636 | $0 | 0 | +62,636 | New Buy |
| Tidal Investments LLC |
| <0.01% | — | #35 | $1.8M | 57,059 | $0 | 0 | +57,059 | New Buy |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | — | #62 | $1.6M | 50,464 | $0 | 0 | +50,464 | New Buy |
| Nuveen, LLC |
| <0.01% | <0.01% | #66 | $1.6M | 49,816 | $437,733 | 24,468 | +25,348+103.60% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #70 | $1.6M | 49,250 | $767,498 | 42,901 | +6,349+14.80% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | — | #58 | $1.6M | 48,123 | $0 | 0 | +48,123 | New Buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #45 | $1.5M | 48,044 | $840,705 | 46,993 | +1,051+2.24% | Add |
| Quantinno Capital Management LP |
| <0.01% | — | #39 | $1.5M | 46,887 | $0 | 0 | +46,887 | New Buy |
| GREAT LAKES ADVISORS, LLC |
| 0.01% | — | #27 | $1.4M | 43,612 | $0 | 0 | +43,612 | New Buy |
| Mirador Capital Partners LP |
| 0.16% | — | #14 | $1.3M | 40,124 | $0 | 0 | +40,124 | New Buy |
| Squarepoint Ops LLC |
| <0.01% | — | #43 | $1.2M | 38,381 | $0 | 0 | +38,381 | New Buy |
| Jump Financial, LLC |
| 0.01% | — | #29 | $1.1M | 32,779 | $0 | 0 | +32,779 | New Buy |
| Sofinnova Investments, Inc. |
| 0.05% | — | #16 | $1.0M | 32,436 | $0 | 0 | +32,436 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #52 | $996,358 | 30,914 | $0 | 0 | +30,914 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #76 | $891,450 | 27,659 | $136,161 | 7,611 | +20,048+263.41% | Add |
