| RA CAPITAL MANAGEMENT, L.P. |
| 6.88% | — | #5 | $791.9M | 28.9M | $0 | 0 | +28.9M | New Buy |
| FMR LLC |
| 0.01% | — | #30 | $281.7M | 10.3M | $0 | 0 | +10.3M | New Buy |
| ARCH Venture Management, LLC |
| 15.95% | — | #4 | $175.5M | 6.4M | $0 | 0 | +6.4M | New Buy |
| venBio Partners LLC |
| 27.75% | — | #2 | $144.1M | 5.3M | $0 | 0 | +5.3M | New Buy |
| Nextech Invest Ltd. |
| 6.08% | — | #7 | $127.6M | 4.7M | $0 | 0 | +4.7M | New Buy |
| Cormorant Asset Management, LP |
| 6.41% | — | #6 | $126.3M | 4.6M | $0 | 0 | +4.6M | New Buy |
| REGENERON PHARMACEUTICALS, INC. |
| 64.35% | — | #1 | $114.0M | 4.2M | $0 | 0 | +4.2M | New Buy |
| Siren, L.L.C. |
| 1.66% | — | #10 | $81.9M | 3.0M | $0 | 0 | +3.0M | New Buy |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.3% | — | #21 | $64.8M | 2.4M | $0 | 0 | +2.4M | New Buy |
| Jupiter Topco LLC |
| 0.03% | — | #28 | $62.7M | 2.3M | $0 | 0 | +2.3M | New Buy |
| Frazier Life Sciences Management, L.P. |
| 1.14% | — | #14 | $52.6M | 1.9M | $0 | 0 | +1.9M | New Buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.54% | — | #18 | $51.5M | 1.9M | $0 | 0 | +1.9M | New Buy |
| General Catalyst Group Management, LLC |
| 23.24% | — | #3 | $43.8M | 1.6M | $0 | 0 | +1.6M | New Buy |
| GENERAL ATLANTIC, L.P. |
| 1.45% | — | #11 | $42.1M | 1.5M | $0 | 0 | +1.5M | New Buy |
| Soleus Capital Management, L.P. |
| 1.38% | — | #12 | $40.1M | 1.5M | $0 | 0 | +1.5M | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #50 | $35.6M | 1.3M | $0 | 0 | +1.3M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #56 | $31.7M | 1.2M | $0 | 0 | +1.2M | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | — | #49 | $30.4M | 1.0M | $0 | 0 | +1.0M | New Buy |
| Foresite Capital Management VI LLC |
| 4.26% | — | #8 | $27.3M | 999,044 | $0 | 0 | +999,044 | New Buy |
| Catalio Capital Management, LP |
| 4.24% | — | #9 | $22.6M | 824,043 | $0 | 0 | +824,043 | New Buy |
| ALLIANCEBERNSTEIN L.P. |
| 0.01% | — | #35 | $22.2M | 810,279 | $0 | 0 | +810,279 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #43 | $20.6M | 751,947 | $0 | 0 | +751,947 | New Buy |
| Casdin Capital, LLC |
| 0.88% | — | #15 | $17.7M | 645,690 | $0 | 0 | +645,690 | New Buy |
| Venrock Adviser, LLC |
| 0.52% | — | #19 | $17.1M | 625,000 | $0 | 0 | +625,000 | New Buy |
| Rock Springs Capital Management LP |
| 0.77% | — | #16 | $15.8M | 578,028 | $0 | 0 | +578,028 | New Buy |
| Samsara BioCapital, LLC |
| 1.25% | — | #13 | $15.2M | 556,044 | $0 | 0 | +556,044 | New Buy |
| Logos Global Management LP |
| 0.62% | — | #17 | $14.4M | 525,000 | $0 | 0 | +525,000 | New Buy |
| BAKER BROS. ADVISORS LP |
| 0.07% | — | #25 | $13.7M | 500,000 | $0 | 0 | +500,000 | New Buy |
| Bellevue Group AG |
| 0.29% | — | #22 | $13.7M | 500,000 | $0 | 0 | +500,000 | New Buy |
| MARSHALL WACE, LLP |
| 0.01% | — | #34 | $12.2M | 445,359 | $0 | 0 | +445,359 | New Buy |
| FRANKLIN RESOURCES INC |
| <0.01% | — | #42 | $10.4M | 381,487 | $0 | 0 | +381,487 | New Buy |
| ICONIQ Capital, LLC |
| 0.28% | — | #23 | $9.6M | 350,000 | $0 | 0 | +350,000 | New Buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| <0.01% | — | #39 | $8.1M | 295,962 | $0 | 0 | +295,962 | New Buy |
| Kynam Capital Management, LP |
| 0.38% | — | #20 | $6.8M | 250,000 | $0 | 0 | +250,000 | New Buy |
| FEDERATED HERMES, INC. |
| 0.01% | — | #33 | $6.7M | 246,200 | $0 | 0 | +246,200 | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #53 | $4.8M | 174,773 | $0 | 0 | +174,773 | New Buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.02% | — | #29 | $2.7M | 100,000 | $0 | 0 | +100,000 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #66 | $2.7M | 99,358 | $0 | 0 | +99,358 | New Buy |
| TD ASSET MANAGEMENT INC |
| <0.01% | — | #44 | $2.1M | 76,982 | $0 | 0 | +76,982 | New Buy |
| Squarepoint Ops LLC |
| <0.01% | — | #51 | $1.3M | 48,484 | $0 | 0 | +48,484 | New Buy |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | — | #48 | $1.2M | 44,045 | $0 | 0 | +44,045 | New Buy |
| UBS Group AG |
| <0.01% | — | #67 | $1.1M | 38,698 | $0 | 0 | +38,698 | New Buy |
| WINTON GROUP Ltd |
| 0.03% | — | #27 | $955,213 | 34,900 | $0 | 0 | +34,900 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #65 | $760,886 | 27,800 | $0 | 0 | +27,800 | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #54 | $664,106 | 24,264 | $0 | 0 | +24,264 | New Buy |
| Hudson Bay Capital Management LP |
| <0.01% | — | #47 | $621,025 | 22,690 | $0 | 0 | +22,690 | New Buy |
| Brevan Howard Capital Management LP |
| <0.01% | — | #36 | $617,604 | 22,565 | $0 | 0 | +22,565 | New Buy |
| Ghisallo Capital Management LLC |
| <0.01% | — | #37 | $547,400 | 20,000 | $0 | 0 | +20,000 | New Buy |
| Mitsubishi UFJ Asset Management Co., Ltd. |
| <0.01% | — | #60 | $525,504 | 19,200 | $0 | 0 | +19,200 | New Buy |
| Vanguard Personalized Indexing Management, LLC |
| <0.01% | — | #40 | $321,023 | 11,729 | $0 | 0 | +11,729 | New Buy |
