| BlackRock, Inc. |
| <0.01% | <0.01% | #85 | $62.0M | 20.4M | $39.4M | 12.8M | +7.6M+59.32% | Add |
| Deep Track Capital, LP |
| 0.85% | — | #3 | $58.5M | 19.3M | $0 | 0 | +19.3M | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #79 | $36.8M | 12.1M | $22.0M | 7.1M | +5.0M+69.32% | Add |
| TCG Crossover Management, LLC |
| 0.73% | — | #4 | $30.4M | 10.0M | $0 | 0 | +10.0M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #110 | $24.9M | 8.2M | $17.4M | 5.7M | +2.5M+44.53% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #80 | $22.3M | 7.3M | $16.6M | 5.4M | +1.9M+36.20% | Add |
| MARSHALL WACE, LLP |
| 0.02% | 0.01% | #28 | $20.8M | 6.8M | $12.4M | 4.0M | +2.8M+70.26% | Add |
| VIKING GLOBAL INVESTORS LP |
| 0.06% | — | #18 | $20.4M | 6.7M | $0 | 0 | +6.7M | New Buy |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.17% | — | #9 | $19.8M | 6.5M | $0 | 0 | +6.5M | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #90 | $15.2M | 5.0M | $9.6M | 3.1M | +1.9M+61.29% | Add |
| Woodline Partners LP |
| 0.03% | — | #24 | $10.3M | 3.4M | $0 | 0 | +3.4M | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $10.1M | 3.3M | $10.0M | 3.3M | +50,931+1.56% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #96 | $8.7M | 2.9M | $7.5M | 2.4M | +413,722+16.94% | Add |
| Trails Edge Capital Partners, LP |
| 1.28% | — | #1 | $8.1M | 2.7M | $0 | 0 | +2.7M | New Buy |
| Nuveen, LLC |
| <0.01% | <0.01% | #68 | $7.3M | 2.4M | $7.2M | 2.3M | +70,753+3.03% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #43 | $7.2M | 2.4M | $7.6M | 2.5M | -97,758-3.94% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #101 | $6.7M | 2.2M | $4.2M | 1.4M | +863,801+63.95% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #99 | $5.3M | 1.7M | $3.0M | 982,373 | +760,186+77.38% | Add |
| GREAT POINT PARTNERS LLC |
| 1% | — | #2 | $5.3M | 1.7M | $0 | 0 | +1.7M | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #104 | $4.9M | 1.6M | $3.1M | 996,721 | +602,505+60.45% | Add |
| Weiss Asset Management LP |
| 0.05% | — | #19 | $4.7M | 1.5M | $0 | 0 | +1.5M | New Buy |
| Nantahala Capital Management, LLC |
| 0.15% | — | #11 | $4.6M | 1.5M | $0 | 0 | +1.5M | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #87 | $3.9M | 1.3M | $2.7M | 869,318 | +423,683+48.74% | Add |
| Cormorant Asset Management, LP |
| 0.19% | — | #8 | $3.8M | 1.3M | $0 | 0 | +1.3M | New Buy |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #76 | $3.7M | 1.2M | $263,198 | 85,454 | +1.1M+1,328.78% | Add |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #47 | $3.5M | 1.2M | $20,621 | 6,695 | +1.2M+17,242.79% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #125 | $2.6M | 866,385 | $2.8M | 904,768 | -38,383-4.24% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #159 | $2.3M | 758,435 | $5.6M | 1.5M | -732,614-49.13% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #147 | $2.3M | 757,919 | $1.8M | 570,203 | +187,716+32.92% | Add |
| Ghisallo Capital Management LLC |
| 0.01% | — | #30 | $2.3M | 750,000 | $0 | 0 | +750,000 | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #168 | $2.3M | 748,974 | $2.1M | 673,964 | +75,010+11.13% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #124 | $2.1M | 689,713 | $1.3M | 413,503 | +276,210+66.80% | Add |
| TANG CAPITAL MANAGEMENT LLC |
| 0.09% | 0.1% | #15 | $2.0M | 666,022 | $2.1M | 666,022 | 00.00% | Unchanged |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #122 | $1.9M | 639,436 | $3.2M | 1.0M | -406,490-38.86% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #132 | $1.9M | 624,499 | $1.1M | 351,681 | +272,818+77.58% | Add |
| Hennion & Walsh Asset Management, Inc. |
| 0.04% | 0.02% | #22 | $1.6M | 518,198 | $622,126 | 201,989 | +316,209+156.55% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #69 | $1.5M | 486,884 | $2.0M | 665,289 | -178,405-26.82% | Reduce |
| Rock Springs Capital Management LP |
| 0.07% | — | #17 | $1.4M | 471,465 | $0 | 0 | +471,465 | New Buy |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #86 | $1.4M | 468,600 | $70,350 | 22,841 | +445,759+1,951.57% | Add |
| Beirne Wealth Consulting Services, LLC |
| 0.26% | 0.36% | #6 | $1.3M | 421,858 | $1.3M | 411,858 | +10,000+2.43% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #139 | $1.3M | 420,300 | $764,326 | 248,158 | +172,142+69.37% | Add |
| IMC-Chicago, LLC |
| <0.01% | <0.01% | #130 | $1.2M | 394,000 | $30,812 | 10,004 | +383,996+3,838.42% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #109 | $1.1M | 371,176 | $1.3M | 435,078 | -63,902-14.69% | Reduce |
| BARCLAYS PLC |
| <0.01% | <0.01% | #145 | $1.1M | 351,587 | $594,042 | 192,871 | +158,716+82.29% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #172 | $1.0M | 332,592 | $701,799 | 227,857 | +104,735+45.97% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #94 | $941,193 | 309,606 | $479,456 | 155,671 | +153,935+98.88% | Add |
| Janney Montgomery Scott LLC |
| <0.01% | <0.01% | #67 | $919,934 | 302,610 | $532,000 | 172,610 | +130,000+75.31% | Add |
| LMR Partners LLP |
| <0.01% | — | #51 | $912,000 | 300,000 | $0 | 0 | +300,000 | New Buy |
| CITIGROUP INC |
| <0.01% | <0.01% | #128 | $893,602 | 293,948 | $235,087 | 76,327 | +217,621+285.12% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #178 | $841,472 | 276,800 | $1.1M | 360,700 | -83,900-23.26% | Reduce |
