| BlackRock, Inc. |
| <0.01% | <0.01% | #78 | $69.8M | 2.8M | $39.7M | 2.3M | +581,321+25.63% | Add |
| Cormorant Asset Management, LP |
| 2.98% | 2.54% | #7 | $58.6M | 2.4M | $50.6M | 2.9M | -500,000-17.30% | Reduce |
| a16z Capital Management, L.L.C. |
| 4.5% | 4.38% | #2 | $56.5M | 3.2M | $56.5M | 3.2M | 00.00% | Unchanged |
| Sofinnova Investments, Inc. |
| 2.91% | 1.52% | #8 | $56.2M | 2.3M | $40.1M | 2.3M | 00.00% | Unchanged |
| Jupiter Topco LLC |
| 0.02% | — | #38 | $52.6M | 2.1M | $0 | 0 | +2.1M | New Buy |
| Octagon Capital Advisors LP |
| 3.85% | 3.38% | #3 | $42.8M | 1.7M | $30.6M | 1.7M | 00.00% | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.36% | 0.31% | #21 | $41.0M | 1.7M | $28.9M | 1.7M | +21,000+1.27% | Add |
| MPM BioImpact LLC |
| 2.49% | — | #9 | $40.9M | 1.7M | $0 | 0 | +1.7M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #84 | $37.8M | 1.5M | $23.7M | 1.4M | +189,308+13.97% | Add |
| Polar Capital Holdings Plc |
| 0.06% | 0.07% | #31 | $26.3M | 1.1M | $19.8M | 1.1M | -60,296-5.32% | Reduce |
| BRAIDWELL LP |
| 0.94% | 0.7% | #15 | $25.3M | 1.0M | $21.0M | 1.2M | -167,458-13.95% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #86 | $25.0M | 1.0M | $14.9M | 850,894 | +170,570+20.05% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #73 | $24.6M | 1.0M | $13.1M | 749,266 | +254,998+34.03% | Add |
| Sands Capital Alternatives, LLC |
| 3.14% | 3.27% | #5 | $19.3M | 786,353 | $13.8M | 786,353 | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.35% | 0.25% | #22 | $18.4M | 752,153 | $12.4M | 711,811 | +40,342+5.67% | Add |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #45 | $18.2M | 742,761 | $12.2M | 699,190 | +43,571+6.23% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.03% | #37 | $17.2M | 702,858 | $23.2M | 1.3M | -624,687-47.06% | Reduce |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 5.2% | 4.08% | #1 | $16.0M | 653,374 | $11.4M | 653,374 | 00.00% | Unchanged |
| Cosmic Management, LLC |
| 3.22% | 3.84% | #4 | $12.3M | 501,833 | $8.8M | 501,833 | 00.00% | Unchanged |
| STEMPOINT CAPITAL LP |
| 1.62% | 1.09% | #10 | $11.4M | 464,171 | $5.9M | 338,654 | +125,517+37.06% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #85 | $10.1M | 412,925 | $2.4M | 137,789 | +275,136+199.68% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #97 | $10.1M | 410,165 | $5.0M | 286,946 | +123,219+42.94% | Add |
| Squadron Capital Management LLC |
| 3.08% | — | #6 | $9.9M | 405,000 | $0 | 0 | +405,000 | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #68 | $9.7M | 394,138 | $3.7M | 214,546 | +179,592+83.71% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.03% | 0.03% | #34 | $9.2M | 377,085 | $7.3M | 420,123 | -43,038-10.24% | Reduce |
| Walleye Capital LLC |
| 0.03% | 0.01% | #35 | $8.7M | 354,395 | $2.7M | 151,674 | +202,721+133.66% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #61 | $8.6M | 349,142 | $851,554 | 48,688 | +300,454+617.10% | Add |
| DIADEMA PARTNERS LP |
| 1.05% | 0.18% | #14 | $8.5M | 346,434 | $1.0M | 60,000 | +286,434+477.39% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #79 | $8.4M | 343,166 | $3.9M | 224,129 | +119,037+53.11% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #44 | $7.4M | 300,000 | $8.7M | 500,000 | -200,000-40.00% | Reduce |
| Integral Health Asset Management, LLC |
| 0.29% | — | #23 | $7.4M | 300,000 | $0 | 0 | +300,000 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #105 | $6.9M | 282,386 | $1.3M | 228,158 | +54,228+23.77% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #71 | $6.9M | 281,967 | $4.6M | 265,373 | +16,594+6.25% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #81 | $6.7M | 273,371 | $4.3M | 247,276 | +26,095+10.55% | Add |
| Comprehensive Financial Management LLC |
| 0.22% | 0.16% | #24 | $6.7M | 271,842 | $4.8M | 271,842 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #93 | $6.6M | 270,769 | $2.7M | 156,438 | +114,331+73.08% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #101 | $6.3M | 257,855 | $1.1M | 61,508 | +196,347+319.22% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $6.1M | 247,621 | $7.5M | 430,463 | -182,842-42.48% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #110 | $5.8M | 233,979 | $2.7M | 173,570 | +60,409+34.80% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #49 | $5.5M | 224,453 | $6.9M | 392,346 | -167,893-42.79% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #75 | $5.4M | 219,600 | $3.4M | 195,937 | +23,663+12.08% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.68% | 0.24% | #17 | $5.2M | 213,671 | $1.5M | 86,518 | +127,153+146.97% | Add |
| Ikarian Capital, LLC |
| 0.52% | — | #18 | $4.9M | 200,000 | $0 | 0 | +200,000 | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #121 | $4.5M | 183,563 | $3.3M | 190,298 | -6,735-3.54% | Reduce |
| Yiheng Capital Management, L.P. |
| 1.55% | — | #12 | $4.2M | 170,532 | $0 | 0 | +170,532 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | <0.01% | #51 | $4.1M | 165,700 | $2.4M | 138,588 | +27,112+19.56% | Add |
| Ensign Peak Advisors, Inc |
| 0.01% | 0.01% | #50 | $3.5M | 141,698 | $2.9M | 166,224 | -24,526-14.75% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #103 | $3.4M | 138,565 | $300,828 | 17,200 | +121,365+705.61% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #117 | $3.1M | 127,420 | $3.1M | 176,110 | -48,690-27.65% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #100 | $2.6M | 107,332 | $1.3M | 75,568 | +31,764+42.03% | Add |
