| PERCEPTIVE ADVISORS LLC |
| 0.12% | — | #12 | $8.0M | 750,000 | $0 | 0 | +750,000 | New Buy |
| ADAR1 Capital Management, LLC |
| 0.32% | — | #5 | $7.0M | 650,000 | $0 | 0 | +650,000 | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | — | #18 | $5.4M | 500,000 | $0 | 0 | +500,000 | New Buy |
| BVF INC/IL |
| 0.14% | — | #10 | $5.4M | 500,000 | $0 | 0 | +500,000 | New Buy |
| Commodore Capital LP |
| 0.32% | — | #6 | $5.4M | 500,000 | $0 | 0 | +500,000 | New Buy |
| TCG Crossover Management, LLC |
| 0.13% | — | #11 | $5.4M | 500,000 | $0 | 0 | +500,000 | New Buy |
| Spruce Street Capital LP |
| 1.05% | — | #1 | $5.4M | 500,000 | $0 | 0 | +500,000 | New Buy |
| Trails Edge Capital Partners, LP |
| 0.85% | — | #2 | $5.4M | 500,000 | $0 | 0 | +500,000 | New Buy |
| Jupiter Topco LLC |
| <0.01% | — | #20 | $4.4M | 400,000 | $0 | 0 | +400,000 | New Buy |
| BRAIDWELL LP |
| 0.16% | — | #9 | $4.3M | 400,000 | $0 | 0 | +400,000 | New Buy |
| Cormorant Asset Management, LP |
| 0.2% | — | #7 | $4.0M | 370,000 | $0 | 0 | +370,000 | New Buy |
| Affinity Asset Advisors, LLC |
| 0.18% | — | #8 | $4.0M | 370,000 | $0 | 0 | +370,000 | New Buy |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.4% | — | #4 | $3.9M | 360,000 | $0 | 0 | +360,000 | New Buy |
| Venrock Adviser, LLC |
| 0.1% | — | #13 | $3.2M | 300,000 | $0 | 0 | +300,000 | New Buy |
| Foresite Capital Management VI LLC |
| 0.5% | — | #3 | $3.2M | 300,000 | $0 | 0 | +300,000 | New Buy |
| J. Goldman & Co LP |
| 0.05% | — | #15 | $1.9M | 177,531 | $0 | 0 | +177,531 | New Buy |
| TORONTO DOMINION BANK |
| <0.01% | — | #19 | $1.6M | 146,811 | $0 | 0 | +146,811 | New Buy |
| Logos Global Management LP |
| 0.05% | — | #16 | $1.1M | 100,000 | $0 | 0 | +100,000 | New Buy |
| ARISTEIA CAPITAL, L.L.C. |
| 0.01% | — | #17 | $535,000 | 50,000 | $0 | 0 | +50,000 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #21 | $362,858 | 33,912 | $0 | 0 | +33,912 | New Buy |
| Lineage Point Capital LP |
| 0.05% | — | #14 | $249,331 | 23,302 | $0 | 0 | +23,302 | New Buy |
| UBS Group AG |
| <0.01% | — | #22 | $171 | 16 | $0 | 0 | +16 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #23 | $75 | 7 | $0 | 0 | +7 | New Buy |
