| FMR LLC |
| 0.01% | 0.01% | #37 | $130.6M | 37.4M | $107.8M | 37.4M | -769-0.00% | Reduce |
| Flagship Pioneering, LLC |
| 5.67% | 6.2% | #1 | $87.3M | 25.0M | $72.0M | 25.0M | 00.00% | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.57% | — | #4 | $65.4M | 18.8M | $0 | 0 | +18.8M | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #83 | $58.2M | 16.7M | $41.0M | 14.2M | +2.4M+17.10% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #78 | $39.1M | 11.2M | $30.3M | 10.5M | +665,048+6.31% | Add |
| CANADA PENSION PLAN INVESTMENT BOARD |
| 0.02% | 0.02% | #20 | $35.7M | 10.2M | $29.4M | 10.2M | -3,500-0.03% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #98 | $29.2M | 8.4M | $21.4M | 7.4M | +940,697+12.65% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #75 | $20.1M | 5.7M | $8.5M | 2.9M | +2.8M+95.07% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #82 | $16.3M | 4.7M | $12.0M | 4.2M | +495,986+11.86% | Add |
| Marex Group plc |
| 0.06% | 0.07% | #12 | $13.9M | 4.0M | $11.5M | 4.0M | -10,000-0.25% | Reduce |
| MARSHALL WACE, LLP |
| 0.01% | <0.01% | #32 | $10.2M | 2.9M | $1.9M | 664,457 | +2.3M+341.18% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #89 | $8.3M | 2.4M | $9.2M | 3.2M | -813,180-25.56% | Reduce |
| Alphabet Inc. |
| 0.19% | 0.2% | #6 | $8.1M | 2.8M | $8.1M | 2.8M | 00.00% | Unchanged |
| Integral Health Asset Management, LLC |
| 0.28% | 0.44% | #5 | $7.0M | 2.0M | $9.2M | 3.2M | -1.2M-37.50% | Reduce |
| TORONTO DOMINION BANK |
| 0.01% | — | #33 | $6.9M | 2.0M | $0 | 0 | +2.0M | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #125 | $6.6M | 1.9M | $4.9M | 1.7M | +174,168+10.20% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.02% | — | #18 | $6.5M | 1.9M | $0 | 0 | +1.9M | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #93 | $5.6M | 1.6M | $4.3M | 1.5M | +125,233+8.47% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #95 | $4.8M | 1.4M | $3.9M | 1.4M | +13,033+0.95% | Add |
| Woodline Partners LP |
| 0.01% | 0.01% | #25 | $4.6M | 1.3M | $3.8M | 1.3M | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #81 | $4.3M | 1.2M | $3.1M | 1.1M | +173,788+16.34% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #36 | $4.3M | 1.2M | $4.2M | 1.5M | -220,100-15.17% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #135 | $4.0M | 1.1M | $3.1M | 876,505 | +263,277+30.04% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #106 | $3.7M | 1.1M | $3.9M | 1.4M | -293,848-21.68% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #77 | $3.4M | 963,147 | $3.2M | 1.1M | -161,132-14.33% | Reduce |
| Omega Fund Management, LLC |
| 1.59% | 1.49% | #3 | $2.9M | 843,750 | $2.4M | 843,750 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #152 | $2.7M | 777,298 | $2.1M | 785,834 | -8,536-1.09% | Reduce |
| Crestline Management, L.P. |
| 4.93% | 4.7% | #2 | $2.6M | 755,736 | $2.2M | 755,736 | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #137 | $2.6M | 731,283 | $2.0M | 685,855 | +45,428+6.62% | Add |
| ArrowMark Colorado Holdings LLC |
| 0.1% | 0.05% | #10 | $2.4M | 685,125 | $2.0M | 685,125 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $2.3M | 653,503 | $4.6M | 1.6M | -937,527-58.93% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #92 | $2.3M | 645,087 | $1.7M | 591,911 | +53,176+8.98% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #66 | $2.2M | 638,837 | $3.5M | 1.2M | -559,742-46.70% | Reduce |
| Corient Private Wealth LLC |
| <0.01% | <0.01% | #65 | $2.2M | 628,200 | $1.8M | 642,100 | -13,900-2.16% | Reduce |
| Point72 Asset Management, L.P. |
| <0.01% | — | #55 | $2.1M | 595,091 | $0 | 0 | +595,091 | New Buy |
| Invesco Ltd. |
| <0.01% | <0.01% | #154 | $1.8M | 504,262 | $1.6M | 569,186 | -64,924-11.41% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #127 | $1.7M | 477,542 | $1.3M | 442,604 | +34,938+7.89% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #124 | $1.3M | 369,722 | $941,680 | 326,972 | +42,750+13.07% | Add |
| Swiss National Bank |
| <0.01% | <0.01% | #96 | $1.2M | 348,100 | $986,688 | 342,600 | +5,500+1.61% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #155 | $1.2M | 341,878 | $2.2M | 769,790 | -427,912-55.59% | Reduce |
| BAKER BROS. ADVISORS LP |
| 0.01% | 0.01% | #40 | $1.1M | 310,483 | $894,191 | 310,483 | 00.00% | Unchanged |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #139 | $1.0M | 294,842 | $838,852 | 291,268 | +3,574+1.23% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #142 | $992,808 | 284,472 | $667,313 | 231,706 | +52,766+22.77% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #170 | $987,377 | 282,916 | $598,000 | 207,492 | +75,424+36.35% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #122 | $951,109 | 272,524 | $173,926 | 60,391 | +212,133+351.27% | Add |
| XTX Topco Ltd |
| 0.01% | 0.01% | #26 | $790,799 | 226,590 | $317,693 | 110,310 | +116,280+105.41% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #99 | $779,695 | 223,412 | $572,232 | 198,696 | +24,716+12.44% | Add |
| Rafferty Asset Management, LLC |
| <0.01% | <0.01% | #67 | $686,591 | 196,731 | $1.0M | 353,582 | -156,851-44.36% | Reduce |
| LOS ANGELES CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $674,557 | 193,283 | $215,502 | 74,827 | +118,456+158.31% | Add |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
| <0.01% | <0.01% | #100 | $634,304 | 181,749 | $471,050 | 163,559 | +18,190+11.12% | Add |
