| RTW INVESTMENTS, LP |
| 1.07% | 1.23% | #6 | $124.9M | 6.6M | $123.7M | 6.6M | 00.00% | Unchanged |
| TCG Crossover Management, LLC |
| 2.8% | — | #3 | $116.6M | 6.1M | $0 | 0 | +6.1M | New Buy |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.95% | 1.14% | #8 | $109.1M | 5.7M | $107.4M | 5.7M | +36,271+0.64% | Add |
| ADAR1 Capital Management, LLC |
| 2.95% | 1.58% | #2 | $64.0M | 3.4M | $26.8M | 1.4M | +1.9M+136.36% | Add |
| FMR LLC |
| <0.01% | <0.01% | #38 | $53.5M | 2.8M | $23.7M | 1.3M | +1.6M+123.01% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #36 | $44.0M | 2.3M | $2.1M | 110,587 | +2.2M+1,993.81% | Add |
| Woodline Partners LP |
| 0.13% | — | #18 | $41.9M | 2.2M | $0 | 0 | +2.2M | New Buy |
| Frazier Life Sciences Management, L.P. |
| 0.79% | 0.92% | #9 | $36.1M | 1.9M | $35.8M | 1.9M | 00.00% | Unchanged |
| BAMCO INC /NY/ |
| 0.05% | 0.09% | #22 | $30.9M | 1.6M | $31.2M | 1.7M | -34,624-2.09% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #37 | $25.4M | 1.3M | $32.4M | 1.7M | -386,926-22.47% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.02% | <0.01% | #24 | $24.7M | 1.3M | $5.8M | 309,723 | +989,671+319.53% | Add |
| Rock Springs Capital Management LP |
| 0.76% | 0.9% | #10 | $15.5M | 814,707 | $15.3M | 814,707 | 00.00% | Unchanged |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #44 | $12.9M | 679,941 | $8.8M | 466,926 | +213,015+45.62% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #55 | $12.6M | 664,462 | $16.3M | 865,146 | -200,684-23.20% | Reduce |
| C WorldWide Group Holding A/S |
| 0.23% | 0.21% | #15 | $9.7M | 510,000 | $9.6M | 510,000 | 00.00% | Unchanged |
| B Group, Inc. |
| 4.02% | 6.28% | #1 | $8.6M | 450,646 | $8.5M | 450,646 | 00.00% | Unchanged |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
| 0.01% | 0.01% | #32 | $7.2M | 393,167 | $7.0M | 393,167 | 00.00% | Unchanged |
| NAN FUNG TRINITY (HK) Ltd |
| 0.65% | 0.72% | #11 | $6.6M | 346,466 | $6.5M | 346,466 | 00.00% | Unchanged |
| Aberdeen Group plc |
| 0.01% | 0.01% | #28 | $5.9M | 311,294 | $4.5M | 237,739 | +73,555+30.94% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #41 | $5.7M | 300,775 | $18,039 | 959 | +299,816+31,263.40% | Add |
| Spruce Street Capital LP |
| 1.04% | — | #7 | $5.3M | 279,110 | $0 | 0 | +279,110 | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #46 | $4.8M | 253,171 | $4.6M | 243,557 | +9,614+3.95% | Add |
| BNP Paribas Asset Management Holding S.A. |
| <0.01% | — | #34 | $4.7M | 246,982 | $0 | 0 | +246,982 | New Buy |
| Hennion & Walsh Asset Management, Inc. |
| 0.12% | 0.14% | #20 | $4.4M | 230,418 | $4.0M | 214,323 | +16,095+7.51% | Add |
| Hudson Bay Capital Management LP |
| 0.01% | <0.01% | #26 | $4.1M | 215,000 | $564,300 | 30,000 | +185,000+616.67% | Add |
| Nantahala Capital Management, LLC |
| 0.13% | — | #19 | $3.8M | 200,000 | $0 | 0 | +200,000 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #53 | $3.5M | 186,365 | $2.7M | 145,448 | +40,917+28.13% | Add |
| NEXTBio Capital Management LP |
| 1.6% | 1.6% | #5 | $3.5M | 183,362 | $3.4M | 183,362 | 00.00% | Unchanged |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 1.87% | 3.71% | #4 | $3.0M | 155,813 | $5.2M | 275,818 | -120,005-43.51% | Reduce |
| Tidal Investments LLC |
| 0.01% | 0.01% | #33 | $2.9M | 153,996 | $3.5M | 183,691 | -29,695-16.17% | Reduce |
| Seven Fleet Capital Management LP |
| 0.48% | 0.46% | #12 | $2.9M | 136,016 | $1.5M | 77,858 | +58,158+74.70% | Add |
| MARSHALL WACE, LLP |
| <0.01% | — | #39 | $2.8M | 147,217 | $0 | 0 | +147,217 | New Buy |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #43 | $2.7M | 141,158 | $1.2M | 63,243 | +77,915+123.20% | Add |
| Privium Fund Management B.V. |
| 0.43% | 0.52% | #13 | $2.3M | 122,189 | $2.5M | 132,189 | -10,000-7.56% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #66 | $2.3M | 120,846 | $2.2M | 118,813 | +2,033+1.71% | Add |
| ALPS ADVISORS INC |
| 0.01% | 0.01% | #27 | $2.1M | 110,431 | $1.7M | 90,848 | +19,583+21.56% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #50 | $1.9M | 101,997 | $3.3M | 174,234 | -72,237-41.46% | Reduce |
| Legal & General Group Plc |
| <0.01% | <0.01% | #52 | $1.4M | 71,461 | $1.3M | 70,014 | +1,447+2.07% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #57 | $1.3M | 69,454 | $9.5M | 504,191 | -434,737-86.22% | Reduce |
| Virtus Investment Advisers, LLC |
| 0.3% | 0.25% | #14 | $1.3M | 68,124 | $893,682 | 47,511 | +20,613+43.39% | Add |
| Headlands Technologies LLC |
| 0.14% | 0.06% | #17 | $1.3M | 68,010 | $528,730 | 28,109 | +39,901+141.95% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #68 | $1.2M | 65,401 | $4.1M | 119,880 | -54,479-45.44% | Reduce |
| DCF Advisers, LLC |
| 0.21% | 0.32% | #16 | $1.2M | 63,500 | $1.2M | 63,500 | 00.00% | Unchanged |
| Quadrature Capital Ltd |
| 0.01% | — | #29 | $741,532 | 39,028 | $0 | 0 | +39,028 | New Buy |
| WealthPlan Investment Management, LLC |
| 0.03% | 0.04% | #23 | $698,459 | 36,761 | $691,474 | 36,761 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #70 | $455,601 | 23,979 | $483,586 | 25,709 | -1,730-6.73% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #75 | $453,701 | 23,879 | $449,163 | 23,879 | 00.00% | Unchanged |
| Invesco Ltd. |
| <0.01% | <0.01% | #71 | $425,543 | 22,397 | $499,556 | 26,558 | -4,161-15.67% | Reduce |
| XTX Topco Ltd |
| <0.01% | 0.02% | #35 | $348,631 | 18,349 | $885,424 | 47,072 | -28,723-61.02% | Reduce |
| Schonfeld Strategic Advisors LLC |
| <0.01% | — | #45 | $294,424 | 15,496 | $0 | 0 | +15,496 | New Buy |
