| FMR LLC |
| 0.01% | — | #41 | $192.1M | 5.8M | $0 | 0 | +5.8M | New Buy |
| Novo Holdings A/S |
| 7.45% | — | #6 | $127.8M | 3.9M | $0 | 0 | +3.9M | New Buy |
| SR ONE CAPITAL MANAGEMENT, LP |
| 10.48% | — | #3 | $108.9M | 3.3M | $0 | 0 | +3.3M | New Buy |
| PERCEPTIVE ADVISORS LLC |
| 1.32% | — | #10 | $88.1M | 2.7M | $0 | 0 | +2.7M | New Buy |
| MONTANOVA CAPITAL, LLC |
| 1.51% | — | #8 | $82.4M | 2.5M | $0 | 0 | +2.5M | New Buy |
| NVP Associates, LLC |
| 22.75% | — | #1 | $74.7M | 2.3M | $0 | 0 | +2.3M | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | — | #34 | $72.5M | 2.2M | $0 | 0 | +2.2M | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | — | #44 | $57.1M | 1.7M | $0 | 0 | +1.7M | New Buy |
| Catalio Capital Management, LP |
| 10.37% | — | #4 | $55.2M | 1.7M | $0 | 0 | +1.7M | New Buy |
| T. Rowe Price Investment Management, Inc. |
| 0.03% | — | #29 | $52.8M | 1.6M | $0 | 0 | +1.6M | New Buy |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.61% | — | #15 | $45.3M | 1.4M | $0 | 0 | +1.4M | New Buy |
| Bellevue Group AG |
| 0.94% | — | #14 | $44.4M | 1.4M | $0 | 0 | +1.4M | New Buy |
| BlackRock, Inc. |
| <0.01% | — | #64 | $32.2M | 977,264 | $0 | 0 | +977,264 | New Buy |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 10.34% | — | #5 | $31.8M | 966,792 | $0 | 0 | +966,792 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | — | #47 | $31.6M | 959,098 | $0 | 0 | +959,098 | New Buy |
| Andera Partners |
| 14.82% | — | #2 | $30.6M | 929,824 | $0 | 0 | +929,824 | New Buy |
| JENNISON ASSOCIATES LLC |
| 0.02% | — | #31 | $26.8M | 812,749 | $0 | 0 | +812,749 | New Buy |
| BRAIDWELL LP |
| 0.98% | — | #13 | $26.4M | 801,395 | $0 | 0 | +801,395 | New Buy |
| TPG GP A, LLC |
| 0.51% | — | #17 | $25.4M | 773,069 | $0 | 0 | +773,069 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #62 | $24.4M | 739,770 | $0 | 0 | +739,770 | New Buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.25% | — | #20 | $24.1M | 731,000 | $0 | 0 | +731,000 | New Buy |
| Rock Springs Capital Management LP |
| 1.07% | — | #12 | $21.8M | 662,918 | $0 | 0 | +662,918 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #59 | $14.3M | 434,650 | $0 | 0 | +434,650 | New Buy |
| Soleus Capital Management, L.P. |
| 0.48% | — | #18 | $13.8M | 419,000 | $0 | 0 | +419,000 | New Buy |
| INFINITUM ASSET MANAGEMENT, LLC |
| 1.38% | — | #9 | $13.5M | 411,378 | $0 | 0 | +411,378 | New Buy |
| BAKER BROS. ADVISORS LP |
| 0.06% | — | #26 | $11.5M | 350,000 | $0 | 0 | +350,000 | New Buy |
| FRANKLIN RESOURCES INC |
| <0.01% | — | #50 | $10.9M | 331,684 | $0 | 0 | +331,684 | New Buy |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 1.13% | — | #11 | $10.9M | 330,487 | $0 | 0 | +330,487 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | — | #58 | $9.3M | 283,854 | $0 | 0 | +283,854 | New Buy |
| FEDERATED HERMES, INC. |
| 0.01% | — | #42 | $5.3M | 160,000 | $0 | 0 | +160,000 | New Buy |
| Woodline Partners LP |
| 0.02% | — | #32 | $5.0M | 150,999 | $0 | 0 | +150,999 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #60 | $4.8M | 146,992 | $0 | 0 | +146,992 | New Buy |
| ADAR1 Capital Management, LLC |
| 0.22% | — | #21 | $4.8M | 146,447 | $0 | 0 | +146,447 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | — | #61 | $4.5M | 136,394 | $0 | 0 | +136,394 | New Buy |
| STEMPOINT CAPITAL LP |
| 0.55% | — | #16 | $3.9M | 118,000 | $0 | 0 | +118,000 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #73 | $3.9M | 117,338 | $0 | 0 | +117,338 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #57 | $3.8M | 116,763 | $0 | 0 | +116,763 | New Buy |
| ACUTA CAPITAL PARTNERS, LLC |
| 2.64% | — | #7 | $3.8M | 115,000 | $0 | 0 | +115,000 | New Buy |
| Burkehill Global Management, LP |
| 0.14% | — | #23 | $3.8M | 115,000 | $0 | 0 | +115,000 | New Buy |
| MOORE CAPITAL MANAGEMENT, LP |
| 0.05% | — | #27 | $3.6M | 110,451 | $0 | 0 | +110,451 | New Buy |
| Blackstone Inc. |
| 0.01% | — | #36 | $3.2M | 97,985 | $0 | 0 | +97,985 | New Buy |
| TD ASSET MANAGEMENT INC |
| <0.01% | — | #49 | $3.1M | 94,636 | $0 | 0 | +94,636 | New Buy |
| SEVEN GRAND MANAGERS, LLC |
| 0.1% | — | #24 | $2.5M | 75,000 | $0 | 0 | +75,000 | New Buy |
| Ghisallo Capital Management LLC |
| 0.01% | — | #33 | $2.3M | 70,000 | $0 | 0 | +70,000 | New Buy |
| Atom Investors LP |
| 0.2% | — | #22 | $2.2M | 68,254 | $0 | 0 | +68,254 | New Buy |
| Aberdeen Group plc |
| <0.01% | — | #48 | $2.2M | 67,174 | $0 | 0 | +67,174 | New Buy |
| Zimmer Partners, LP |
| 0.05% | — | #28 | $2.1M | 62,500 | $0 | 0 | +62,500 | New Buy |
| Avidity Partners Management LP |
| 0.32% | — | #19 | $2.0M | 60,000 | $0 | 0 | +60,000 | New Buy |
| LMR Partners LLP |
| 0.01% | — | #43 | $1.8M | 54,323 | $0 | 0 | +54,323 | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #67 | $1.6M | 50,045 | $0 | 0 | +50,045 | New Buy |
