| BAKER BROS. ADVISORS LP |
| 0.61% | 0.49% | #9 | $122.3M | 11.0M | $84.5M | 11.0M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #92 | $99.2M | 9.0M | $47.7M | 6.2M | +2.7M+43.58% | Add |
| RTW INVESTMENTS, LP |
| 0.7% | 0.56% | #8 | $82.0M | 7.4M | $56.3M | 7.4M | +54,665+0.74% | Add |
| Ridgeback Capital Investments L.P. |
| 100% | — | #1 | $80.9M | 7.3M | $0 | 0 | +7.3M | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #56 | $50.4M | 4.6M | $17.4M | 2.3M | +2.3M+99.84% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #93 | $49.2M | 4.4M | $28.9M | 3.8M | +657,907+17.39% | Add |
| MONTANOVA CAPITAL, LLC |
| 0.89% | 0.82% | #7 | $48.6M | 4.4M | $32.3M | 4.2M | +168,000+3.98% | Add |
| Boxer Capital Management, LLC |
| 3.32% | 1.18% | #3 | $44.1M | 4.0M | $9.0M | 1.2M | +2.8M+238.98% | Add |
| Caption Management, LLC |
| 0.2% | 0.06% | #15 | $43.8M | 4.0M | $10.9M | 1.4M | +2.5M+177.85% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #120 | $32.1M | 2.9M | $21.1M | 2.8M | +136,884+4.96% | Add |
| FCPM III SERVICES B.V. |
| 4.14% | 2.97% | #2 | $31.1M | 2.8M | $21.5M | 2.8M | 00.00% | Unchanged |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #72 | $28.6M | 2.6M | $5.0M | 654,245 | +1.9M+294.61% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| 0.01% | <0.01% | #50 | $28.4M | 2.6M | $2.0M | 255,495 | +2.3M+904.42% | Add |
| Logos Global Management LP |
| 1.19% | — | #6 | $27.7M | 2.5M | $0 | 0 | +2.5M | New Buy |
| Erste Asset Management GmbH |
| 0.18% | 0.14% | #16 | $23.7M | 2.1M | $15.3M | 2.1M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #100 | $22.5M | 2.0M | $13.8M | 1.8M | +233,662+12.97% | Add |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #49 | $22.0M | 2.0M | $17.9M | 2.3M | -346,564-14.83% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #70 | $21.3M | 1.9M | $6.3M | 823,829 | +1.1M+134.06% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #88 | $20.4M | 1.8M | $17.8M | 2.3M | -482,229-20.78% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | 0.01% | #84 | $17.9M | 1.6M | $62.1M | 8.1M | -6.5M-80.04% | Reduce |
| Opaleye Management Inc. |
| 1.39% | — | #5 | $15.3M | 1.4M | $0 | 0 | +1.4M | New Buy |
| TORONTO DOMINION BANK |
| 0.02% | 0.02% | #40 | $14.1M | 1.3M | $12.2M | 1.6M | -316,030-19.86% | Reduce |
| DIADEMA PARTNERS LP |
| 1.64% | 1% | #4 | $13.3M | 1.2M | $5.9M | 766,060 | +432,740+56.49% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #87 | $12.5M | 1.1M | $4.4M | 581,210 | +547,066+94.13% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #61 | $11.0M | 990,458 | $3.7M | 483,433 | +507,025+104.88% | Add |
| Artisan Partners Limited Partnership |
| 0.02% | — | #37 | $10.8M | 973,496 | $0 | 0 | +973,496 | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #137 | $10.3M | 929,375 | $15.6M | 2.0M | -1.1M-54.56% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #123 | $8.0M | 724,244 | $1.5M | 190,925 | +533,319+279.33% | Add |
| Point72 Asset Management, L.P. |
| 0.01% | — | #51 | $8.0M | 723,262 | $0 | 0 | +723,262 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #142 | $7.7M | 693,003 | $5.8M | 1.4M | -682,516-49.62% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #145 | $7.5M | 681,756 | $4.2M | 552,576 | +129,180+23.38% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #83 | $7.5M | 677,524 | $440,747 | 57,614 | +619,910+1,075.97% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #115 | $7.4M | 665,618 | $4.5M | 589,120 | +76,498+12.99% | Add |
| ADAR1 Capital Management, LLC |
| 0.33% | 0.76% | #12 | $7.3M | 655,784 | $12.9M | 1.7M | -1.0M-61.03% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #112 | $7.1M | 639,986 | $4.7M | 611,759 | +28,227+4.61% | Add |
| Eversept Partners, LP |
| 0.34% | 0.16% | #11 | $6.5M | 590,252 | $3.0M | 386,861 | +203,391+52.57% | Add |
| Susquehanna Portfolio Strategies, LLC |
| 0.1% | 0.02% | #18 | $6.0M | 545,109 | $1.2M | 152,828 | +392,281+256.68% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #105 | $6.0M | 542,963 | $2.6M | 334,622 | +208,341+62.26% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #109 | $5.6M | 502,130 | $8.7M | 1.1M | -637,969-55.96% | Reduce |
| Jefferies Financial Group Inc. |
| 0.04% | 0.04% | #27 | $5.5M | 495,465 | $5.5M | 714,225 | -218,760-30.63% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #101 | $5.4M | 489,190 | $3.6M | 475,126 | +14,064+2.96% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #91 | $4.5M | 408,877 | $119,256 | 15,589 | +393,288+2,522.86% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #157 | $3.6M | 329,385 | $1.9M | 253,449 | +75,936+29.96% | Add |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #78 | $3.4M | 307,600 | $802,293 | 104,875 | +202,725+193.30% | Add |
| ARMISTICE CAPITAL, LLC |
| 0.04% | — | #28 | $2.9M | 264,000 | $0 | 0 | +264,000 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #140 | $2.6M | 235,405 | $1.6M | 204,791 | +30,614+14.95% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #141 | $2.4M | 215,302 | $1.5M | 197,578 | +17,724+8.97% | Add |
| Woodline Partners LP |
| 0.01% | 0.01% | #54 | $2.1M | 191,424 | $2.9M | 380,988 | -189,564-49.76% | Reduce |
| Creative Planning |
| <0.01% | <0.01% | #107 | $1.9M | 174,164 | $375,470 | 49,081 | +125,083+254.85% | Add |
| Engineers Gate Manager LP |
| 0.02% | 0.01% | #34 | $1.9M | 172,998 | $1.2M | 150,494 | +22,504+14.95% | Add |
