| Sanofi |
| 30.86% | 31.44% | #1 | $164.8M | 12.2M | $105.6M | 12.2M | 00.00% | Unchanged |
| PERCEPTIVE ADVISORS LLC |
| 2.19% | 1.75% | #6 | $145.7M | 10.8M | $89.3M | 10.3M | +460,555+4.46% | Add |
| Rubric Capital Management LP |
| 1.13% | 0.64% | #8 | $122.9M | 9.1M | $60.6M | 7.0M | +2.1M+30.00% | Add |
| JOHNSON & JOHNSON |
| 11.23% | 8.82% | #2 | $89.7M | 6.6M | $57.5M | 6.6M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #73 | $64.3M | 4.8M | $27.4M | 3.2M | +1.6M+50.16% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.08% | 0.05% | #21 | $59.4M | 4.4M | $34.6M | 4.0M | +400,000+10.00% | Add |
| Opaleye Management Inc. |
| 4.34% | 2.42% | #4 | $48.0M | 3.6M | $18.4M | 2.1M | +1.4M+67.20% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #35 | $40.1M | 3.0M | $30.0M | 3.5M | -493,947-14.25% | Reduce |
| 683 Capital Management, LLC |
| 1.53% | 1.11% | #7 | $31.1M | 2.3M | $21.2M | 2.5M | -150,000-6.12% | Reduce |
| Woodline Partners LP |
| 0.06% | 0.01% | #23 | $20.3M | 1.5M | $2.6M | 300,323 | +1.2M+399.51% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #85 | $18.8M | 1.4M | $6.5M | 753,378 | +639,844+84.93% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #74 | $17.7M | 1.3M | $10.2M | 1.2M | +70,709+5.69% | Add |
| Knoll Capital Management, LLC |
| 9.68% | 5.74% | #3 | $16.9M | 1.3M | $10.8M | 1.3M | 00.00% | Unchanged |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.26% | 0.16% | #14 | $14.9M | 1.1M | $7.4M | 858,379 | +247,042+28.78% | Add |
| Long Focus Capital Management, LLC |
| 0.38% | 0.12% | #12 | $14.6M | 1.1M | $4.5M | 524,745 | +555,555+105.87% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.05% | <0.01% | #24 | $13.7M | 1.0M | $118,408 | 13,673 | +1.0M+7,324.16% | Add |
| D. E. Shaw & Co., Inc. |
| 0.01% | <0.01% | #43 | $11.5M | 852,902 | $3.7M | 425,281 | +427,621+100.55% | Add |
| HEIGHTS CAPITAL MANAGEMENT, INC |
| 2.65% | — | #5 | $11.5M | 850,000 | $0 | 0 | +850,000 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #82 | $11.5M | 849,082 | $5.1M | 584,899 | +264,183+45.17% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #90 | $9.8M | 723,563 | $3.4M | 397,281 | +326,282+82.13% | Add |
| J. Goldman & Co LP |
| 0.24% | 0.05% | #15 | $9.3M | 684,772 | $1.8M | 206,210 | +478,562+232.08% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #72 | $8.8M | 650,489 | $1.0M | 115,995 | +534,494+460.79% | Add |
| Erste Asset Management GmbH |
| 0.07% | 0.05% | #22 | $8.7M | 691,200 | $5.8M | 719,702 | -28,502-3.96% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #55 | $8.6M | 639,459 | $1.1M | 132,454 | +507,005+382.78% | Add |
| Jupiter Topco LLC |
| <0.01% | — | #52 | $6.4M | 475,757 | $0 | 0 | +475,757 | New Buy |
| PFM Health Sciences, LP |
| 0.53% | — | #10 | $6.2M | 455,286 | $0 | 0 | +455,286 | New Buy |
| Hennion & Walsh Asset Management, Inc. |
| 0.16% | 0.1% | #17 | $5.7M | 421,979 | $3.1M | 354,755 | +67,224+18.95% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #80 | $5.5M | 409,855 | $2.4M | 271,879 | +137,976+50.75% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.01% | — | #33 | $4.7M | 350,174 | $0 | 0 | +350,174 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #93 | $4.4M | 327,416 | $3.8M | 441,414 | -113,998-25.83% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #109 | $3.9M | 289,720 | $2.1M | 244,944 | +44,776+18.28% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #50 | $2.7M | 202,393 | $614,453 | 70,953 | +131,440+185.25% | Add |
| Ghisallo Capital Management LLC |
| 0.02% | — | #30 | $2.7M | 200,000 | $0 | 0 | +200,000 | New Buy |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #75 | $2.7M | 196,583 | $961,199 | 110,993 | +85,590+77.11% | Add |
| Privium Fund Management B.V. |
| 0.49% | 0.38% | #11 | $2.6M | 196,112 | $1.8M | 212,112 | -16,000-7.54% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #126 | $2.6M | 205,212 | $196,894 | 24,338 | +180,874+743.18% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #100 | $2.5M | 184,574 | $2.6M | 303,198 | -118,624-39.12% | Reduce |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #53 | $2.2M | 162,412 | $160,937 | 18,584 | +143,828+773.93% | Add |
| Y-Intercept (Hong Kong) Ltd |
| 0.04% | — | #27 | $2.0M | 148,065 | $0 | 0 | +148,065 | New Buy |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #63 | $2.0M | 147,329 | $841,474 | 97,168 | +50,161+51.62% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #99 | $1.9M | 142,923 | $1.1M | 126,331 | +16,592+13.13% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #107 | $1.9M | 142,434 | $867,680 | 100,194 | +42,240+42.16% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #101 | $1.9M | 138,352 | $866,837 | 100,097 | +38,255+38.22% | Add |
| BLAIR WILLIAM & CO/IL |
| <0.01% | <0.01% | #48 | $1.7M | 125,478 | $1.1M | 125,422 | +56+0.04% | Add |
| Voleon Capital Management LP |
| 0.03% | <0.01% | #28 | $1.6M | 117,790 | $193,629 | 22,359 | +95,431+426.81% | Add |
| Swiss National Bank |
| <0.01% | — | #78 | $1.5M | 111,400 | $0 | 0 | +111,400 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #108 | $1.3M | 98,955 | $330,275 | 38,138 | +60,817+159.47% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #131 | $1.3M | 94,540 | $817,807 | 94,435 | +105+0.11% | Add |
| ALPS ADVISORS INC |
| 0.01% | — | #42 | $1.3M | 93,186 | $0 | 0 | +93,186 | New Buy |
| Prosight Management, LP |
| 0.21% | 3.73% | #16 | $1.2M | 90,000 | $22.8M | 2.6M | -2.5M-96.58% | Reduce |
