| FMR LLC |
| 0.01% | 0.01% | #50 | $296.7M | 52.2M | $223.0M | 52.0M | +240,702+0.46% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #99 | $156.9M | 27.6M | $107.7M | 25.1M | +2.5M+10.08% | Add |
| Decheng Capital LLC |
| 20.15% | 16.84% | #2 | $147.4M | 26.0M | $111.3M | 26.0M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #119 | $67.7M | 11.9M | $49.9M | 11.6M | +293,316+2.52% | Add |
| Omega Fund Management, LLC |
| 24.72% | 21.25% | #1 | $45.9M | 8.1M | $34.7M | 8.1M | 00.00% | Unchanged |
| Laurion Capital Management LP |
| 1.14% | 1.46% | #7 | $44.4M | 7.8M | $33.6M | 7.8M | -2,625-0.03% | Reduce |
| UBS Group AG |
| 0.01% | <0.01% | #69 | $42.6M | 7.5M | $5.9M | 1.4M | +6.1M+445.26% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #126 | $41.9M | 7.4M | $29.1M | 6.8M | +585,867+8.63% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #106 | $35.5M | 6.2M | $25.2M | 5.9M | +381,151+6.50% | Add |
| Duquesne Family Office LLC |
| 0.49% | 0.58% | #10 | $25.8M | 4.5M | $19.5M | 4.5M | 00.00% | Unchanged |
| AMERICAN CENTURY COMPANIES INC |
| 0.01% | 0.01% | #53 | $25.6M | 4.5M | $12.4M | 2.9M | +1.6M+55.32% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #123 | $20.0M | 3.5M | $13.8M | 3.2M | +309,922+9.63% | Add |
| TANG CAPITAL MANAGEMENT LLC |
| 0.85% | 0.69% | #8 | $18.7M | 3.3M | $13.5M | 3.1M | +150,000+4.76% | Add |
| Redmile Group, LLC |
| 1.16% | 0.9% | #6 | $17.2M | 3.0M | $13.5M | 3.2M | -122,247-3.88% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #147 | $15.3M | 2.7M | $9.8M | 2.3M | +413,220+18.16% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #74 | $13.4M | 2.4M | $8.6M | 2.0M | +360,671+18.07% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #113 | $13.2M | 2.3M | $8.6M | 2.0M | +318,765+15.91% | Add |
| ALGERT GLOBAL LLC |
| 0.15% | 0.12% | #15 | $12.9M | 2.3M | $7.9M | 1.8M | +435,280+23.63% | Add |
| HRT FINANCIAL LP |
| 0.02% | — | #38 | $12.5M | 2.2M | $0 | 0 | +2.2M | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #121 | $12.0M | 2.1M | $9.9M | 2.3M | -184,581-8.01% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #110 | $11.7M | 2.1M | $8.5M | 2.0M | +66,419+3.33% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #102 | $11.6M | 2.0M | $8.8M | 2.1M | -4,815-0.23% | Reduce |
| ARMISTICE CAPITAL, LLC |
| 0.14% | 0.13% | #16 | $11.4M | 2.0M | $7.4M | 1.7M | +264,000+15.21% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #132 | $10.8M | 1.9M | $8.3M | 1.9M | -25,267-1.31% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #100 | $10.1M | 1.8M | $6.8M | 1.6M | +184,105+11.56% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.02% | 0.01% | #41 | $10.0M | 1.8M | $5.2M | 1.2M | +549,049+45.46% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | <0.01% | #79 | $9.2M | 1.6M | $6.2M | 1.4M | +182,329+12.67% | Add |
| Knoll Capital Management, LLC |
| 5.21% | 3.41% | #3 | $9.1M | 1.6M | $6.4M | 1.5M | +100,000+6.67% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #164 | $8.3M | 1.5M | $4.9M | 1.3M | +137,838+10.45% | Add |
| Jump Financial, LLC |
| 0.06% | 0.02% | #24 | $7.7M | 1.4M | $1.1M | 262,557 | +1.1M+417.38% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | <0.01% | #56 | $7.6M | 1.3M | $2.4M | 559,180 | +786,815+140.71% | Add |
| FIRST TRUST ADVISORS LP |
| <0.01% | — | #78 | $7.4M | 1.3M | $0 | 0 | +1.3M | New Buy |
| ABRAMS CAPITAL MANAGEMENT, L.P. |
| 0.13% | 0.12% | #17 | $7.2M | 1.3M | $5.5M | 1.3M | 00.00% | Unchanged |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #70 | $7.1M | 1.2M | $11.5M | 2.7M | -1.4M-53.49% | Reduce |
| NewEdge Advisors, LLC |
| 0.02% | 0.02% | #40 | $7.0M | 1.2M | $4.4M | 1.0M | +200,621+19.46% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #91 | $6.5M | 1.1M | $1.7M | 392,986 | +747,014+190.09% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #159 | $6.4M | 1.1M | $2.3M | 539,613 | +578,966+107.29% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #118 | $6.2M | 1.1M | $2.2M | 514,117 | +569,511+110.77% | Add |
| SILVERCREST ASSET MANAGEMENT GROUP LLC |
| 0.04% | 0.02% | #31 | $5.8M | 1.0M | $3.1M | 724,383 | +297,143+41.02% | Add |
| Woodline Partners LP |
| 0.02% | 0.02% | #44 | $5.5M | 975,532 | $4.1M | 960,414 | +15,118+1.57% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #146 | $4.1M | 715,781 | $2.9M | 672,144 | +43,637+6.49% | Add |
| ESSEX INVESTMENT MANAGEMENT CO LLC |
| 0.5% | — | #9 | $3.8M | 671,041 | $0 | 0 | +671,041 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #150 | $3.8M | 669,687 | $2.9M | 683,497 | -13,810-2.02% | Reduce |
| Beacon Pointe Advisors, LLC |
| 0.02% | 0.01% | #46 | $3.6M | 632,251 | $2.8M | 643,734 | -11,483-1.78% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #186 | $3.3M | 587,392 | $1.9M | 437,806 | +149,586+34.17% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | — | #54 | $3.0M | 534,759 | $0 | 0 | +534,759 | New Buy |
| ACT CAPITAL MANAGEMENT, LLC |
| 1.93% | 0.98% | #4 | $3.0M | 520,000 | $1.2M | 290,000 | +230,000+79.31% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #157 | $2.9M | 509,871 | $2.2M | 512,161 | -2,290-0.45% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #202 | $2.9M | 515,696 | $2.2M | 539,162 | -23,466-4.35% | Reduce |
| Swiss National Bank |
| <0.01% | <0.01% | #120 | $2.8M | 486,800 | $1.9M | 437,400 | +49,400+11.29% | Add |
