| FMR LLC |
| 0.01% | 0.01% | #39 | $298.9M | 7.2M | $224.3M | 7.2M | +3,955+0.06% | Add |
| TRV GP V, LLC |
| 52.53% | 55.68% | #1 | $261.7M | 6.3M | $223.3M | 7.1M | -854,708-11.98% | Reduce |
| ARCH Venture Management, LLC |
| 14.12% | 17.23% | #3 | $155.4M | 3.7M | $116.7M | 3.7M | 00.00% | Unchanged |
| Capital International Investors |
| 0.03% | 0.02% | #35 | $121.8M | 2.9M | $96.9M | 3.1M | -176,015-5.68% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #44 | $121.3M | 2.9M | $92.1M | 2.9M | -31,802-1.08% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #76 | $112.5M | 2.7M | $78.4M | 2.5M | +193,831+7.73% | Add |
| Cormorant Asset Management, LP |
| 5.62% | 4.65% | #5 | $110.7M | 2.7M | $92.5M | 3.0M | -300,000-10.14% | Reduce |
| Sofinnova Investments, Inc. |
| 4.1% | 2.26% | #6 | $79.4M | 1.9M | $59.6M | 1.9M | 00.00% | Unchanged |
| JOHNSON & JOHNSON |
| 9.31% | 8.56% | #4 | $74.4M | 1.8M | $55.8M | 1.8M | 00.00% | Unchanged |
| Polar Capital Holdings Plc |
| 0.16% | 0.18% | #24 | $67.0M | 1.6M | $51.4M | 1.6M | -33,947-2.07% | Reduce |
| BAKER BROS. ADVISORS LP |
| 0.32% | 0.28% | #15 | $64.5M | 1.5M | $48.4M | 1.5M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #85 | $56.1M | 1.3M | $41.5M | 1.3M | +21,430+1.62% | Add |
| TRV GP VI, LLC |
| 17.39% | 22.37% | #2 | $40.4M | 969,218 | $30.3M | 969,218 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #90 | $34.1M | 818,712 | $23.8M | 759,552 | +59,160+7.79% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #75 | $33.1M | 793,453 | $22.6M | 721,622 | +71,831+9.95% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #59 | $32.8M | 787,446 | $27.1M | 866,456 | -79,010-9.12% | Reduce |
| PERCEPTIVE ADVISORS LLC |
| 0.48% | 0.41% | #12 | $32.2M | 773,342 | $21.1M | 673,923 | +99,419+14.75% | Add |
| Vestal Point Capital, LP |
| 0.71% | 1.26% | #9 | $30.4M | 730,000 | $44.9M | 1.4M | -706,229-49.17% | Reduce |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | 0.01% | #52 | $26.8M | 644,082 | $28.8M | 918,866 | -274,784-29.90% | Reduce |
| Siren, L.L.C. |
| 0.54% | 0.56% | #11 | $26.7M | 641,469 | $20.1M | 641,469 | 00.00% | Unchanged |
| Capital World Investors |
| <0.01% | <0.01% | #66 | $23.0M | 551,657 | $16.8M | 536,607 | +15,050+2.80% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #48 | $21.7M | 693,384 | $22.1M | 727,843 | -34,459-4.73% | Reduce |
| T. Rowe Price Investment Management, Inc. |
| 0.01% | 0.01% | #43 | $16.4M | 393,200 | $19.4M | 620,600 | -227,400-36.64% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #65 | $15.1M | 362,114 | $7.0M | 224,498 | +137,616+61.30% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #99 | $15.0M | 359,944 | $10.0M | 320,909 | +39,035+12.16% | Add |
| Candriam S.C.A. |
| 0.07% | — | #30 | $14.5M | 347,650 | $0 | 0 | +347,650 | New Buy |
| Sio Capital Management, LLC |
| 2.12% | 1.65% | #7 | $12.8M | 307,657 | $11.5M | 366,809 | -59,152-16.13% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #100 | $12.4M | 297,612 | $8.2M | 274,568 | +23,044+8.39% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #80 | $11.6M | 277,305 | $7.4M | 237,992 | +39,313+16.52% | Add |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.19% | 0.17% | #22 | $10.5M | 250,795 | $8.1M | 257,431 | -6,636-2.58% | Reduce |
| Burkehill Global Management, LP |
| 0.38% | 0.39% | #14 | $10.4M | 250,000 | $7.8M | 250,000 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #79 | $10.3M | 246,815 | $7.5M | 239,917 | +6,898+2.88% | Add |
| ALGERT GLOBAL LLC |
| 0.11% | — | #26 | $9.3M | 223,822 | $0 | 0 | +223,822 | New Buy |
| Invesco Ltd. |
| <0.01% | <0.01% | #96 | $9.0M | 215,236 | $5.4M | 171,757 | +43,479+25.31% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #53 | $9.0M | 214,831 | $5.5M | 175,449 | +39,382+22.45% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #72 | $8.7M | 208,333 | $5.9M | 189,253 | +19,080+10.08% | Add |
| Ensign Peak Advisors, Inc |
| 0.01% | 0.01% | #42 | $6.9M | 165,546 | $6.1M | 194,200 | -28,654-14.75% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #69 | $6.5M | 154,908 | $10.0M | 319,552 | -164,644-51.52% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #91 | $6.3M | 151,174 | $4.7M | 151,758 | -584-0.38% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #47 | $6.3M | 150,000 | $4.7M | 150,000 | 00.00% | Unchanged |
| Artia Global Partners LP |
| 1.07% | 0.87% | #8 | $5.8M | 138,508 | $4.3M | 138,508 | 00.00% | Unchanged |
| Swedbank AB |
| <0.01% | <0.01% | #54 | $4.9M | 117,400 | $3.5M | 113,200 | +4,200+3.71% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #89 | $4.3M | 103,361 | $2.2M | 71,508 | +31,853+44.54% | Add |
| Walleye Capital LLC |
| 0.02% | <0.01% | #37 | $4.3M | 102,163 | $348,821 | 11,148 | +91,015+816.42% | Add |
| Woodline Partners LP |
| 0.01% | — | #40 | $4.1M | 97,537 | $0 | 0 | +97,537 | New Buy |
| TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #58 | $3.8M | 91,878 | $3.1M | 99,078 | -7,200-7.27% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #102 | $3.6M | 86,988 | $2.4M | 78,231 | +8,757+11.19% | Add |
| PRUDENTIAL FINANCIAL INC |
| <0.01% | <0.01% | #55 | $3.6M | 86,885 | $3.6M | 114,815 | -27,930-24.33% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | — | #114 | $3.4M | 82,442 | $0 | 0 | +82,442 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #104 | $3.4M | 82,222 | $2.3M | 72,319 | +9,903+13.69% | Add |
