| Frazier Life Sciences Management, L.P. |
| 3.27% | 3.51% | #6 | $150.2M | 5.0M | $136.3M | 4.6M | +465,641+10.20% | Add |
| TRV GP IV, LLC |
| 52.63% | 50.04% | #1 | $133.5M | 4.5M | $133.5M | 4.5M | 00.00% | Unchanged |
| ARCH Venture Management, LLC |
| 11.18% | 18.16% | #3 | $123.0M | 4.1M | $123.0M | 4.1M | 00.00% | Unchanged |
| Deep Track Capital, LP |
| 1.62% | 1.7% | #12 | $111.4M | 3.7M | $103.8M | 3.5M | +255,007+7.33% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #76 | $104.5M | 3.5M | $76.7M | 2.6M | +932,416+36.27% | Add |
| Jupiter Topco LLC |
| 0.04% | — | #38 | $101.8M | 3.4M | $0 | 0 | +3.4M | New Buy |
| T. Rowe Price Investment Management, Inc. |
| 0.05% | — | #35 | $77.7M | 2.6M | $0 | 0 | +2.6M | New Buy |
| Logos Global Management LP |
| 2.49% | 1.84% | #8 | $57.7M | 1.9M | $36.9M | 1.2M | +700,000+56.68% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #85 | $53.1M | 1.8M | $42.9M | 1.4M | +342,566+23.86% | Add |
| a16z Capital Management, L.L.C. |
| 4.05% | 3.94% | #5 | $50.8M | 1.7M | $50.8M | 1.7M | 00.00% | Unchanged |
| Venrock Adviser, LLC |
| 1.45% | 1.78% | #13 | $47.8M | 1.6M | $47.8M | 1.6M | 00.00% | Unchanged |
| Alphabet Inc. |
| 0.97% | 1.03% | #18 | $41.4M | 1.4M | $41.4M | 1.4M | 00.00% | Unchanged |
| BRAIDWELL LP |
| 1.26% | — | #16 | $34.0M | 1.1M | $0 | 0 | +1.1M | New Buy |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.15% | 0.06% | #27 | $33.1M | 1.1M | $11.1M | 373,000 | +734,814+197.00% | Add |
| FMR LLC |
| <0.01% | <0.01% | #83 | $31.5M | 1.1M | $25.8M | 864,214 | +192,745+22.30% | Add |
| General Catalyst Group Management, LLC |
| 16.4% | 16.85% | #2 | $30.9M | 1.0M | $30.9M | 1.0M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #91 | $29.8M | 997,533 | $19.0M | 636,722 | +360,811+56.67% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.17% | 0.14% | #26 | $28.5M | 954,886 | $19.0M | 636,162 | +318,724+50.10% | Add |
| TRV GP V, LLC |
| 5.69% | 7.08% | #4 | $28.4M | 950,800 | $28.4M | 950,800 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #77 | $28.0M | 964,011 | $1.7M | 58,446 | +905,565+1,549.40% | Add |
| MARSHALL WACE, LLP |
| 0.02% | 0.01% | #45 | $27.3M | 914,572 | $9.3M | 310,639 | +603,933+194.42% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #68 | $26.1M | 874,876 | $24.2M | 809,214 | +65,662+8.11% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #84 | $25.6M | 858,054 | $17.9M | 599,967 | +258,087+43.02% | Add |
| Casdin Capital, LLC |
| 1.26% | 1.72% | #15 | $25.2M | 843,857 | $22.7M | 758,857 | +85,000+11.20% | Add |
| ArrowMark Colorado Holdings LLC |
| 0.95% | 0.61% | #19 | $22.9M | 767,383 | $22.9M | 767,383 | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.07% | 0.07% | #32 | $22.0M | 736,216 | $19.4M | 650,229 | +85,987+13.22% | Add |
| BESSEMER GROUP INC |
| 0.02% | 0.02% | #46 | $14.4M | 481,790 | $14.4M | 481,790 | 00.00% | Unchanged |
| SPHERA FUNDS MANAGEMENT LTD. |
| 1.63% | 1.08% | #11 | $12.5M | 417,564 | $6.8M | 227,343 | +190,221+83.67% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #107 | $11.7M | 393,107 | $5.8M | 195,542 | +197,565+101.03% | Add |
| Aberdeen Group plc |
| 0.02% | 0.01% | #48 | $11.5M | 383,773 | $6.8M | 226,227 | +157,546+69.64% | Add |
| Ikarian Capital, LLC |
| 1.2% | 0.95% | #17 | $11.3M | 378,999 | $11.7M | 393,399 | -14,400-3.66% | Reduce |
| Hillhouse Capital Advisors, Ltd. |
| 1.31% | 0.65% | #14 | $10.9M | 366,028 | $10.9M | 366,028 | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.47% | 0.09% | #22 | $10.1M | 339,276 | $1.5M | 50,095 | +289,181+577.27% | Add |
| Squadron Capital Management LLC |
| 3.1% | 2.82% | #7 | $10.0M | 335,000 | $7.7M | 257,500 | +77,500+30.10% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #101 | $9.6M | 321,227 | $5.8M | 195,084 | +126,143+64.66% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #88 | $8.8M | 294,742 | $6.3M | 211,382 | +83,360+39.44% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #94 | $8.7M | 293,144 | $8.3M | 279,713 | +13,431+4.80% | Add |
| Candriam S.C.A. |
| 0.04% | — | #39 | $8.2M | 273,932 | $0 | 0 | +273,932 | New Buy |
| Hudson Bay Capital Management LP |
| 0.02% | <0.01% | #44 | $8.1M | 270,000 | $243,278 | 8,150 | +261,850+3,212.88% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #87 | $7.8M | 260,566 | $5.6M | 186,433 | +74,133+39.76% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.05% | #54 | $7.4M | 248,000 | $35.2M | 1.2M | -930,000-78.95% | Reduce |
| Mass General Brigham, Inc |
| 1.98% | 1.53% | #10 | $7.2M | 239,994 | $7.2M | 239,994 | 00.00% | Unchanged |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #82 | $6.8M | 227,425 | $3.2M | 107,486 | +119,939+111.59% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #79 | $6.6M | 219,938 | $4.5M | 151,000 | +68,938+45.65% | Add |
| RTW INVESTMENTS, LP |
| 0.05% | — | #34 | $6.3M | 212,000 | $0 | 0 | +212,000 | New Buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
| <0.01% | <0.01% | #65 | $5.8M | 199,872 | $1.1M | 37,181 | +162,691+437.56% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #64 | $5.8M | 192,952 | $472,973 | 15,845 | +177,107+1,117.75% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.08% | 0.11% | #30 | $5.6M | 188,857 | $8.5M | 284,476 | -95,619-33.61% | Reduce |
| ExodusPoint Capital Management, LP |
| 0.04% | — | #40 | $5.5M | 183,264 | $0 | 0 | +183,264 | New Buy |
| SummitTX Capital, L.P. |
| 0.14% | 0.08% | #28 | $5.3M | 176,291 | $2.5M | 83,750 | +92,541+110.50% | Add |
