| RA CAPITAL MANAGEMENT, L.P. |
| 1.87% | 1.53% | #10 | $215.4M | 7.3M | $144.3M | 7.3M | 00.00% | Unchanged |
| T. Rowe Price Investment Management, Inc. |
| 0.12% | 0.09% | #22 | $188.2M | 6.3M | $131.4M | 6.6M | -267,293-4.05% | Reduce |
| Siren, L.L.C. |
| 3.37% | 3.2% | #8 | $166.4M | 5.6M | $115.4M | 5.8M | -200,000-3.45% | Reduce |
| Vestal Point Capital, LP |
| 3.64% | 3.02% | #6 | $155.9M | 5.3M | $107.9M | 5.4M | -175,000-3.23% | Reduce |
| Deep Track Capital, LP |
| 1.77% | 1.32% | #12 | $121.7M | 4.1M | $80.8M | 4.1M | +37,500+0.92% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #79 | $114.2M | 3.8M | $56.6M | 2.8M | +1.0M+35.32% | Add |
| Jupiter Topco LLC |
| 0.04% | — | #32 | $94.0M | 3.2M | $0 | 0 | +3.2M | New Buy |
| Red Tree Management, LLC |
| 63.77% | 56.39% | #1 | $93.9M | 3.2M | $63.1M | 3.2M | -6,992-0.22% | Reduce |
| TPG GP A, LLC |
| 1.79% | 1.63% | #11 | $89.4M | 3.0M | $59.9M | 3.0M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #86 | $65.8M | 2.2M | $35.3M | 1.8M | +442,419+24.94% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #77 | $60.8M | 2.0M | $28.2M | 1.4M | +629,532+44.35% | Add |
| Royalty Pharma Sub-Manager, LLC |
| 25.05% | 27.02% | #3 | $60.6M | 2.4M | $46.7M | 2.4M | 00.00% | Unchanged |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #47 | $58.0M | 2.0M | $32.3M | 1.6M | +330,249+20.37% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #59 | $56.5M | 1.9M | $27.4M | 1.4M | +528,050+38.37% | Add |
| FMR LLC |
| <0.01% | <0.01% | #69 | $56.2M | 1.9M | $41.8M | 2.1M | -207,859-9.89% | Reduce |
| Omega Fund Management, LLC |
| 29.14% | 29.16% | #2 | $54.1M | 1.8M | $47.6M | 2.4M | -570,000-23.83% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #76 | $34.5M | 1.2M | $16.5M | 830,906 | +331,729+39.92% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #82 | $29.8M | 1.0M | $3.4M | 177,408 | +838,557+472.67% | Add |
| Jones Hill Capital LP |
| 5.63% | 5.37% | #4 | $26.5M | 892,621 | $25.1M | 1.3M | -367,515-29.16% | Reduce |
| ACORN CAPITAL ADVISORS, LLC |
| 5.21% | 3.64% | #5 | $19.1M | 643,381 | $12.8M | 643,382 | -1-0.00% | Reduce |
| Aisling Capital Management LP |
| 3.58% | 2.38% | #7 | $16.9M | 568,919 | $11.3M | 568,919 | 00.00% | Unchanged |
| Palo Alto Investors LP |
| 2.39% | 1.67% | #9 | $16.3M | 550,408 | $10.9M | 550,408 | 00.00% | Unchanged |
| Rock Springs Capital Management LP |
| 0.78% | 0.57% | #17 | $15.9M | 535,286 | $9.7M | 489,095 | +46,191+9.44% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #88 | $15.5M | 520,567 | $11.1M | 558,964 | -38,397-6.87% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.01% | <0.01% | #55 | $14.8M | 498,193 | $5.5M | 276,943 | +221,250+79.89% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #68 | $13.7M | 461,724 | $2.2M | 109,261 | +352,463+322.59% | Add |
| NAN FUNG TRINITY (HK) Ltd |
| 1.25% | 0.93% | #14 | $12.7M | 427,885 | $8.5M | 427,885 | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #117 | $12.4M | 418,912 | $5.8M | 290,939 | +127,973+43.99% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #87 | $11.8M | 396,343 | $5.1M | 255,571 | +140,772+55.08% | Add |
| Candriam S.C.A. |
| 0.05% | — | #30 | $11.1M | 373,380 | $0 | 0 | +373,380 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #85 | $10.9M | 365,481 | $5.3M | 263,985 | +101,496+38.45% | Add |
| Walleye Capital LLC |
| 0.04% | 0.01% | #33 | $10.5M | 353,226 | $2.1M | 108,008 | +245,218+227.04% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #109 | $10.5M | 352,904 | $6.5M | 327,989 | +24,915+7.60% | Add |
| Ensign Peak Advisors, Inc |
| 0.02% | 0.01% | #43 | $10.2M | 342,211 | $8.0M | 401,444 | -59,233-14.75% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #75 | $9.3M | 313,739 | $4.3M | 216,753 | +96,986+44.74% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #97 | $9.0M | 302,942 | $34.3M | 1.7M | -1.4M-82.45% | Reduce |
| Clearbridge Investments, LLC |
| 0.01% | 0.01% | #53 | $8.6M | 289,785 | $5.8M | 289,221 | +564+0.20% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #78 | $8.6M | 288,749 | $314,620 | 15,818 | +272,931+1,725.45% | Add |
| DAFNA Capital Management LLC |
| 1.61% | 1.91% | #13 | $8.5M | 284,955 | $8.4M | 421,733 | -136,778-32.43% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #126 | $8.4M | 283,884 | $1.6M | 100,028 | +183,856+183.80% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #67 | $7.8M | 262,254 | $3.1M | 156,702 | +105,552+67.36% | Add |
| TD ASSET MANAGEMENT INC |
| 0.01% | <0.01% | #56 | $7.8M | 261,118 | $5.4M | 269,718 | -8,600-3.19% | Reduce |
| ALGERT GLOBAL LLC |
| 0.08% | 0.1% | #26 | $6.9M | 233,232 | $6.6M | 330,833 | -97,601-29.50% | Reduce |
| Woodline Partners LP |
| 0.02% | 0.02% | #38 | $6.9M | 232,690 | $4.6M | 232,690 | 00.00% | Unchanged |
| SEB Asset Management AB |
| 0.03% | — | #34 | $6.9M | 232,156 | $0 | 0 | +232,156 | New Buy |
| ORBIMED ADVISORS LLC |
| 0.11% | 0.26% | #24 | $5.7M | 191,100 | $13.3M | 667,300 | -476,200-71.36% | Reduce |
| Atle Fund Management AB |
| 1.16% | 0.75% | #15 | $4.3M | 145,657 | $2.3M | 1.2M | -1.0M-87.55% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #90 | $4.3M | 144,010 | $2.6M | 131,656 | +12,354+9.38% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #114 | $3.6M | 120,666 | $1.7M | 83,264 | +37,402+44.92% | Add |
| Napean Trading & Investment Co (Singapore) PTE Ltd |
| 1.16% | 0.97% | #16 | $3.4M | 113,780 | $2.3M | 113,780 | 00.00% | Unchanged |
