| BlackRock, Inc. |
| <0.01% | <0.01% | #94 | $62.7M | 30.1M | $46.6M | 19.1M | +11.1M+57.91% | Add |
| PFIZER INC |
| 27.55% | 20.85% | #1 | $46.9M | 22.0M | $49.8M | 22.0M | 00.00% | Unchanged |
| Frazier Life Sciences Management, L.P. |
| 1.02% | 0.24% | #6 | $46.7M | 22.4M | $9.3M | 3.8M | +18.7M+491.22% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #88 | $39.6M | 19.0M | $21.1M | 8.7M | +10.4M+119.69% | Add |
| TPG GP A, LLC |
| 0.78% | 1.24% | #8 | $38.9M | 18.7M | $45.7M | 18.7M | 00.00% | Unchanged |
| Sio Capital Management, LLC |
| 4.59% | — | #2 | $27.7M | 13.3M | $0 | 0 | +13.3M | New Buy |
| PRIMECAP MANAGEMENT CO/CA/ |
| 0.02% | 0.02% | #30 | $27.3M | 13.1M | $20.4M | 8.4M | +4.7M+56.61% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #114 | $25.3M | 12.2M | $16.9M | 6.9M | +5.2M+75.78% | Add |
| FMR LLC |
| <0.01% | <0.01% | #91 | $25.0M | 12.0M | $3.9M | 1.6M | +10.4M+655.37% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #71 | $21.3M | 10.2M | $16.8M | 6.9M | +3.3M+48.44% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #37 | $16.2M | 7.8M | $13.1M | 5.4M | +2.4M+44.81% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #102 | $14.7M | 7.0M | $10.1M | 4.1M | +2.9M+70.93% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #90 | $12.8M | 6.1M | $6.7M | 2.8M | +3.4M+122.29% | Add |
| GordonMD Global Investments LP |
| 4.36% | 2.43% | #3 | $11.0M | 5.3M | $3.5M | 1.4M | +3.9M+270.49% | Add |
| MARSHALL WACE, LLP |
| 0.01% | 0.01% | #48 | $10.6M | 5.1M | $8.4M | 3.4M | +1.6M+47.78% | Add |
| Patient Square Capital LP |
| 1.63% | 1.49% | #5 | $10.5M | 5.1M | $8.4M | 3.5M | +1.6M+46.38% | Add |
| Aberdeen Group plc |
| 0.01% | 0.01% | #32 | $10.4M | 5.0M | $3.6M | 1.5M | +3.5M+242.07% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #65 | $10.1M | 4.8M | $8.1M | 3.3M | +1.5M+45.81% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #59 | $9.8M | 4.7M | $6.7M | 2.8M | +1.9M+70.45% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #93 | $9.6M | 4.6M | $13.1M | 5.4M | -741,619-13.78% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #117 | $9.4M | 4.5M | $1.6M | 1.3M | +3.2M+247.14% | Add |
| Woodline Partners LP |
| 0.03% | 0.03% | #20 | $9.4M | 4.5M | $8.5M | 3.5M | +999,546+28.55% | Add |
| Candriam S.C.A. |
| 0.04% | 0.02% | #17 | $9.0M | 4.3M | $3.2M | 2.3M | +2.0M+88.07% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #124 | $8.8M | 4.2M | $4.1M | 1.7M | +2.5M+148.63% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #38 | $8.0M | 3.8M | $5.2M | 2.1M | +1.7M+79.23% | Add |
| HRT FINANCIAL LP |
| 0.01% | <0.01% | #35 | $7.5M | 3.6M | $47,000 | 19,605 | +3.6M+18,372.73% | Add |
| Walleye Capital LLC |
| 0.02% | — | #23 | $6.8M | 3.3M | $0 | 0 | +3.3M | New Buy |
| RTW INVESTMENTS, LP |
| 0.06% | — | #14 | $6.8M | 3.3M | $0 | 0 | +3.3M | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #85 | $6.7M | 3.2M | $2.9M | 1.2M | +2.0M+169.55% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #120 | $6.6M | 3.2M | $5.2M | 2.1M | +1.1M+49.33% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #100 | $6.3M | 3.0M | $3.9M | 1.6M | +1.4M+89.42% | Add |
| Ghisallo Capital Management LLC |
| 0.04% | — | #19 | $6.2M | 3.0M | $0 | 0 | +3.0M | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #104 | $6.1M | 3.0M | $3.1M | 1.3M | +1.7M+129.86% | Add |
| Wildcat Capital Management, LLC |
| 2.66% | 6.71% | #4 | $6.1M | 2.9M | $7.1M | 2.9M | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #108 | $4.7M | 2.3M | $3.4M | 1.4M | +877,830+62.86% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #80 | $4.2M | 2.0M | $6.1M | 2.5M | -478,492-19.26% | Reduce |
| DAFNA Capital Management LLC |
| 0.79% | 0.76% | #7 | $4.2M | 2.0M | $3.3M | 1.4M | +629,882+45.97% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #96 | $3.8M | 1.8M | $2.7M | 1.1M | +746,535+68.38% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #151 | $3.2M | 1.4M | $3.2M | 1.4M | +3,787+0.26% | Add |
| Boxer Capital Management, LLC |
| 0.23% | 0.87% | #10 | $3.1M | 1.5M | $6.6M | 2.7M | -1.2M-44.95% | Reduce |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | 0.02% | #39 | $3.0M | 1.5M | $4.9M | 2.0M | -558,405-27.73% | Reduce |
| Raiffeisen Bank International AG |
| 0.03% | 0.02% | #21 | $2.4M | 1.1M | $1.6M | 702,000 | +400,000+56.98% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #161 | $1.6M | 772,786 | $1.7M | 684,519 | +88,267+12.89% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #137 | $1.5M | 727,182 | $964,255 | 395,187 | +331,995+84.01% | Add |
| Hennion & Walsh Asset Management, Inc. |
| 0.04% | — | #16 | $1.5M | 722,928 | $0 | 0 | +722,928 | New Buy |
| Man Group plc |
| <0.01% | <0.01% | #72 | $1.5M | 701,901 | $377,427 | 154,683 | +547,218+353.77% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | — | #126 | $1.4M | 678,972 | $0 | 0 | +678,972 | New Buy |
| Nuveen, LLC |
| <0.01% | <0.01% | #130 | $1.3M | 624,648 | $5.6M | 2.3M | -1.7M-73.02% | Reduce |
| IEQ CAPITAL, LLC |
| 0.01% | 0.01% | #57 | $1.2M | 580,371 | $1.5M | 614,189 | -33,818-5.51% | Reduce |
| Mitsubishi UFJ Asset Management Co., Ltd. |
| <0.01% | <0.01% | #107 | $1.1M | 547,189 | $1.0M | 428,700 | +118,489+27.64% | Add |
