| ADAR1 Capital Management, LLC |
| 0.06% | — | #4 | $1.2M | 800,000 | $0 | 0 | +800,000 | New Buy |
| Vivo Capital, LLC |
| 0.11% | — | #3 | $1.2M | 798,377 | $0 | 0 | +798,377 | New Buy |
| Squadron Capital Management LLC |
| 0.16% | — | #2 | $503,750 | 325,000 | $0 | 0 | +325,000 | New Buy |
| Ikarian Capital, LLC |
| 0.04% | — | #5 | $379,788 | 245,025 | $0 | 0 | +245,025 | New Buy |
| MONTANOVA CAPITAL, LLC |
| <0.01% | — | #7 | $155,000 | 100,000 | $0 | 0 | +100,000 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | — | #10 | $115,078 | 74,244 | $0 | 0 | +74,244 | New Buy |
| SABBY MANAGEMENT, LLC |
| 0.54% | 0.97% | #1 | $69,704 | 44,970 | $142,046 | 220,260 | -175,290-79.58% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | — | #16 | $66,771 | 43,078 | $0 | 0 | +43,078 | New Buy |
| Venrock Adviser, LLC |
| <0.01% | — | #11 | $50,662 | 32,685 | $0 | 0 | +32,685 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #17 | $40,430 | 26,084 | $30,293 | 46,973 | -20,889-44.47% | Reduce |
| SEVEN GRAND MANAGERS, LLC |
| <0.01% | — | #9 | $38,750 | 25,000 | $0 | 0 | +25,000 | New Buy |
| Scientech Research LLC |
| 0.02% | — | #6 | $23,965 | 15,461 | $0 | 0 | +15,461 | New Buy |
| Crestwood Advisors Group, LLC |
| <0.01% | — | #13 | $23,095 | 14,900 | $0 | 0 | +14,900 | New Buy |
| TWO SIGMA SECURITIES, LLC |
| <0.01% | <0.01% | #12 | $16,965 | 10,945 | $12,071 | 18,718 | -7,773-41.53% | Reduce |
| Stratos Wealth Partners, LTD. |
| <0.01% | — | #14 | $16,678 | 10,760 | $0 | 0 | +10,760 | New Buy |
| Private Wealth Management Group, LLC |
| <0.01% | <0.01% | #8 | $7,750 | 5,000 | $3,225 | 5,000 | 00.00% | Unchanged |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #15 | $465 | 300 | $193 | 300 | 00.00% | Unchanged |
| Banque Cantonale Vaudoise |
| <0.01% | — | #18 | $9 | 6 | $0 | 0 | +6 | New Buy |
| Federation des caisses Desjardins du Quebec |
| <0.01% | <0.01% | #19 | $4 | 2 | $2 | 2 | 00.00% | Unchanged |
