| Frazier Life Sciences Management, L.P. |
| 8% | 5.11% | #3 | $367.2M | 6.7M | $198.6M | 6.7M | 00.00% | Unchanged |
| FMR LLC |
| 0.01% | <0.01% | #50 | $293.8M | 5.3M | $87.7M | 2.9M | +2.4M+81.25% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.05% | 0.02% | #44 | $274.8M | 5.0M | $95.3M | 3.2M | +1.8M+55.95% | Add |
| NEA Management Company, LLC |
| 12.56% | 6.13% | #2 | $199.5M | 3.6M | $107.9M | 3.6M | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 3.57% | 2.15% | #6 | $189.3M | 3.4M | $108.6M | 3.6M | -209,151-5.75% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #75 | $183.5M | 3.3M | $87.8M | 2.9M | +382,266+13.00% | Add |
| Paradigm Biocapital Advisors LP |
| 2.59% | — | #9 | $138.4M | 2.5M | $0 | 0 | +2.5M | New Buy |
| NVP Associates, LLC |
| 35.93% | 36.2% | #1 | $117.9M | 2.1M | $63.8M | 2.1M | 00.00% | Unchanged |
| Deep Track Capital, LP |
| 1.39% | 1.34% | #13 | $95.6M | 1.7M | $82.3M | 2.8M | -1.0M-37.17% | Reduce |
| Polar Capital Holdings Plc |
| 0.21% | 0.17% | #30 | $88.8M | 1.6M | $48.4M | 1.6M | -13,672-0.84% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #85 | $81.6M | 1.5M | $44.1M | 1.5M | -204-0.01% | Reduce |
| Aaron Wealth Advisors LLC |
| 3.27% | 1.98% | #7 | $64.5M | 1.2M | $34.9M | 1.2M | -377-0.03% | Reduce |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.34% | 0.22% | #24 | $58.3M | 1.1M | $30.4M | 1.0M | +38,367+3.77% | Add |
| Kynam Capital Management, LP |
| 2.85% | 1.72% | #8 | $51.6M | 934,799 | $27.9M | 934,799 | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.15% | 0.1% | #34 | $49.7M | 900,092 | $26.9M | 900,063 | +29+0.00% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.64% | 0.44% | #20 | $48.2M | 873,492 | $26.6M | 890,000 | -16,508-1.85% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #91 | $47.7M | 864,466 | $23.5M | 787,208 | +77,258+9.81% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #65 | $45.0M | 814,807 | $30.7M | 1.0M | -214,200-20.82% | Reduce |
| Parkman Healthcare Partners LLC |
| 4.52% | 2.46% | #5 | $44.2M | 800,173 | $23.9M | 800,037 | +136+0.02% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #78 | $42.7M | 773,072 | $20.0M | 670,385 | +102,687+15.32% | Add |
| BRAIDWELL LP |
| 1.45% | 1.49% | #12 | $39.2M | 710,880 | $44.6M | 1.5M | -781,587-52.37% | Reduce |
| TCG Crossover Management, LLC |
| 0.86% | 0.56% | #18 | $35.9M | 650,000 | $19.4M | 650,000 | 00.00% | Unchanged |
| Cormorant Asset Management, LP |
| 1.54% | 1.68% | #11 | $30.4M | 550,000 | $33.4M | 1.1M | -570,000-50.89% | Reduce |
| Soleus Capital Management, L.P. |
| 0.98% | 0.22% | #17 | $28.4M | 515,279 | $5.3M | 178,897 | +336,382+188.03% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #80 | $25.3M | 459,005 | $13.7M | 457,945 | +1,060+0.23% | Add |
| MARSHALL WACE, LLP |
| 0.02% | <0.01% | #48 | $22.2M | 401,885 | $1.9M | 62,703 | +339,182+540.93% | Add |
| Caption Management, LLC |
| 0.1% | — | #38 | $22.1M | 400,000 | $0 | 0 | +400,000 | New Buy |
| EcoR1 Capital, LLC |
| 1.04% | 0.98% | #16 | $21.4M | 388,500 | $23.2M | 777,000 | -388,500-50.00% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #106 | $19.1M | 346,717 | $8.8M | 293,295 | +53,422+18.21% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #100 | $16.5M | 298,927 | $858,188 | 28,750 | +270,177+939.75% | Add |
| Rock Springs Capital Management LP |
| 0.8% | 0.51% | #19 | $16.5M | 298,218 | $8.6M | 287,967 | +10,251+3.56% | Add |
| Candriam S.C.A. |
| 0.07% | — | #39 | $16.0M | 289,893 | $0 | 0 | +289,893 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #82 | $15.1M | 272,747 | $10.4M | 346,914 | -74,167-21.38% | Reduce |
| Opaleye Management Inc. |
| 1.3% | 1.02% | #14 | $14.4M | 260,000 | $7.8M | 260,000 | 00.00% | Unchanged |
| FRANKLIN RESOURCES INC |
| <0.01% | — | #73 | $13.9M | 252,665 | $0 | 0 | +252,665 | New Buy |
| Schonfeld Strategic Advisors LLC |
| 0.05% | 0.03% | #43 | $13.7M | 248,670 | $3.7M | 123,814 | +124,856+100.84% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #113 | $13.7M | 248,558 | $785,191 | 44,868 | +203,690+453.98% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #88 | $13.6M | 246,678 | $6.3M | 210,575 | +36,103+17.14% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #77 | $12.9M | 233,700 | $1.4M | 46,753 | +186,947+399.86% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #86 | $12.9M | 233,095 | $6.4M | 214,908 | +18,187+8.46% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #66 | $12.5M | 226,151 | $16.8M | 564,415 | -338,264-59.93% | Reduce |
| Tetragon Partners GP Ltd |
| 1.77% | 0.84% | #10 | $11.2M | 203,543 | $4.3M | 145,480 | +58,063+39.91% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #76 | $11.1M | 201,429 | $5.1M | 170,154 | +31,275+18.38% | Add |
| Caligan Partners LP |
| 0.52% | 1.69% | #23 | $11.0M | 200,000 | $25.3M | 848,590 | -648,590-76.43% | Reduce |
| D. E. Shaw & Co., Inc. |
| <0.01% | 0.01% | #60 | $10.1M | 182,767 | $8.6M | 288,889 | -106,122-36.73% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #114 | $8.4M | 152,084 | $3.1M | 102,387 | +49,697+48.54% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #128 | $7.5M | 139,611 | $4.0M | 147,057 | -7,446-5.06% | Reduce |
| KVP Capital Advisors, LP |
| 4.92% | 2.71% | #4 | $6.7M | 121,524 | $3.6M | 121,524 | 00.00% | Unchanged |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #64 | $6.3M | 113,475 | $3.4M | 115,075 | -1,600-1.39% | Reduce |
| Burkehill Global Management, LP |
| 0.2% | 0.15% | #31 | $5.5M | 100,000 | $3.0M | 100,000 | 00.00% | Unchanged |
