| BlackRock, Inc. |
| <0.01% | <0.01% | #54 | $219.8M | 13.7M | $157.2M | 13.0M | +615,343+4.72% | Add |
| PRIMECAP MANAGEMENT CO/CA/ |
| 0.1% | 0.1% | #16 | $163.9M | 10.2M | $124.7M | 10.3M | -156,700-1.52% | Reduce |
| BVF INC/IL |
| 2.94% | 2.74% | #1 | $114.9M | 7.1M | $86.0M | 7.1M | 00.00% | Unchanged |
| RTW INVESTMENTS, LP |
| 0.93% | 0.81% | #6 | $109.1M | 6.8M | $81.7M | 6.8M | 00.00% | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.74% | 0.63% | #7 | $84.9M | 5.3M | $59.1M | 4.9M | +377,037+7.70% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #66 | $79.8M | 5.0M | $52.5M | 4.4M | +601,980+13.83% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #97 | $52.8M | 3.3M | $37.4M | 3.1M | +177,155+5.71% | Add |
| TCG Crossover Management, LLC |
| 0.95% | 0.85% | #5 | $39.5M | 2.5M | $29.6M | 2.5M | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #50 | $37.9M | 2.4M | $18.8M | 1.6M | +795,989+51.01% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #81 | $35.7M | 2.2M | $42.2M | 3.5M | -1.3M-36.70% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #78 | $30.9M | 1.9M | $21.9M | 1.8M | +105,282+5.80% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #85 | $28.2M | 1.8M | $10.6M | 900,837 | +851,719+94.55% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #62 | $21.0M | 1.3M | $13.1M | 1.1M | +223,755+20.67% | Add |
| BAKER BROS. ADVISORS LP |
| 0.09% | 0.08% | #17 | $17.7M | 1.1M | $13.3M | 1.1M | 00.00% | Unchanged |
| Legal & General Group Plc |
| <0.01% | <0.01% | #51 | $17.6M | 1.1M | $12.9M | 1.1M | +24,397+2.29% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #58 | $16.3M | 1.0M | $15.6M | 1.3M | -283,768-21.91% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #89 | $15.6M | 968,778 | $9.2M | 763,793 | +204,985+26.84% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #49 | $13.7M | 853,677 | $7.4M | 609,788 | +243,889+40.00% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #37 | $13.2M | 819,515 | $9.7M | 805,421 | +14,094+1.75% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #86 | $12.8M | 794,279 | $9.0M | 744,519 | +49,760+6.68% | Add |
| JOHNSON & JOHNSON |
| 1.51% | 1.38% | #3 | $12.0M | 748,062 | $9.0M | 748,062 | 00.00% | Unchanged |
| Jefferies Financial Group Inc. |
| 0.08% | 0.06% | #18 | $11.6M | 720,440 | $8.7M | 720,440 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #82 | $11.4M | 707,242 | $8.4M | 696,854 | +10,388+1.49% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.03% | 0.03% | #26 | $11.0M | 680,182 | $7.5M | 620,756 | +59,426+9.57% | Add |
| Deep Track Capital, LP |
| 0.14% | — | #11 | $9.6M | 593,551 | $0 | 0 | +593,551 | New Buy |
| TORONTO DOMINION BANK |
| 0.01% | 0.01% | #39 | $7.9M | 491,000 | $5.9M | 491,000 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #76 | $7.8M | 487,084 | $5.7M | 471,076 | +16,008+3.40% | Add |
| Seven Fleet Capital Management LP |
| 1.29% | 0.31% | #4 | $7.8M | 368,305 | $964,800 | 80,000 | +288,305+360.38% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #61 | $7.8M | 483,834 | $2.0M | 162,415 | +321,419+197.90% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #99 | $6.6M | 410,769 | $4.8M | 395,941 | +14,828+3.75% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #98 | $6.2M | 382,094 | $1.5M | 121,342 | +260,752+214.89% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #143 | $5.8M | 360,396 | $4.4M | 366,093 | -5,697-1.56% | Reduce |
| PRINCIPAL FINANCIAL GROUP INC |
| <0.01% | <0.01% | #60 | $5.8M | 358,229 | $4.2M | 347,078 | +11,151+3.21% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #149 | $4.2M | 260,612 | $3.2M | 263,844 | -3,232-1.22% | Reduce |
| Velan Capital Investment Management LP |
| 2.5% | 1.89% | #2 | $4.1M | 255,000 | $3.0M | 250,000 | +5,000+2.00% | Add |
| PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.01% | 0.01% | #36 | $4.1M | 254,741 | $3.1M | 255,472 | -731-0.29% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.17% | 0.07% | #10 | $3.7M | 232,560 | $1.1M | 93,665 | +138,895+148.29% | Add |
| Hudson Bay Capital Management LP |
| 0.01% | 0.02% | #38 | $3.4M | 210,000 | $5.9M | 487,320 | -277,320-56.91% | Reduce |
| BARCLAYS PLC |
| <0.01% | <0.01% | #120 | $3.3M | 203,619 | $2.6M | 218,354 | -14,735-6.75% | Reduce |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| <0.01% | <0.01% | #48 | $3.2M | 200,000 | $2.4M | 200,000 | 00.00% | Unchanged |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #145 | $3.1M | 190,826 | $4.6M | 377,699 | -186,873-49.48% | Reduce |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #68 | $2.9M | 181,617 | $2.1M | 170,461 | +11,156+6.54% | Add |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #94 | $2.9M | 180,205 | $2.1M | 175,177 | +5,028+2.87% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #102 | $2.7M | 167,189 | $1.3M | 104,299 | +62,890+60.30% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #174 | $2.6M | 167,089 | $2.3M | 201,890 | -34,801-17.24% | Reduce |
| Susquehanna Portfolio Strategies, LLC |
| 0.04% | 0.02% | #24 | $2.6M | 159,584 | $1.7M | 138,124 | +21,460+15.54% | Add |
| KORNITZER CAPITAL MANAGEMENT INC /KS |
| 0.05% | — | #23 | $2.4M | 151,410 | $0 | 0 | +151,410 | New Buy |
| Trexquant Investment LP |
| 0.01% | <0.01% | #32 | $2.3M | 144,555 | $536,561 | 44,491 | +100,064+224.91% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #127 | $2.2M | 139,370 | $1.6M | 134,778 | +4,592+3.41% | Add |
| Jump Financial, LLC |
| 0.02% | <0.01% | #31 | $2.1M | 131,000 | $127,004 | 10,531 | +120,469+1,143.95% | Add |
