| Trium Capital LLP |
| 6.76% | 2.97% | #8 | $10.98B | 390,268 | $4.2M | 191,391 | +198,877+103.91% | Add |
| AyurMaya Capital Management Company, LP |
| 100% | — | #1 | $426.0M | 15.1M | $0 | 0 | +15.1M | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #85 | $231.3M | 8.2M | $158.0M | 7.2M | +1.0M+14.60% | Add |
| FMR LLC |
| 0.01% | <0.01% | #63 | $190.5M | 6.8M | $21.5M | 973,782 | +5.8M+595.14% | Add |
| Deep Track Capital, LP |
| 2.6% | 2.44% | #19 | $178.6M | 6.3M | $149.2M | 6.8M | -424,037-6.26% | Reduce |
| Samsara BioCapital, LLC |
| 14.67% | 13.58% | #5 | $178.6M | 6.3M | $139.8M | 6.3M | 00.00% | Unchanged |
| Foresite Capital Management V, LLC |
| 45.81% | 47.94% | #2 | $165.9M | 5.9M | $129.9M | 5.9M | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #58 | $146.3M | 5.2M | $72.4M | 3.3M | +1.9M+58.21% | Add |
| venBio Partners LLC |
| 24.53% | 35.56% | #3 | $127.4M | 4.5M | $99.8M | 4.5M | 00.00% | Unchanged |
| Foresite Capital Management VI LLC |
| 18.6% | 20.33% | #4 | $119.5M | 4.2M | $93.6M | 4.2M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #99 | $118.6M | 4.2M | $88.8M | 4.0M | +183,437+4.55% | Add |
| Nextech Invest Ltd. |
| 4.75% | 5.49% | #11 | $99.6M | 3.5M | $78.0M | 3.5M | 00.00% | Unchanged |
| Cormorant Asset Management, LP |
| 4.69% | 4.37% | #12 | $92.5M | 3.3M | $87.0M | 3.9M | -663,645-16.80% | Reduce |
| Saturn V Capital Management LP |
| 11.76% | 12.77% | #6 | $82.0M | 2.9M | $70.5M | 3.2M | -286,632-8.95% | Reduce |
| Octagon Capital Advisors LP |
| 7.16% | 6.9% | #7 | $79.7M | 2.8M | $62.4M | 2.8M | 00.00% | Unchanged |
| Jupiter Topco LLC |
| 0.03% | — | #49 | $66.2M | 2.4M | $0 | 0 | +2.4M | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #113 | $61.5M | 2.2M | $39.7M | 1.8M | +385,454+21.39% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #89 | $61.0M | 2.2M | $42.3M | 1.9M | +250,102+13.04% | Add |
| MPM BioImpact LLC |
| 3.46% | 4.06% | #18 | $56.8M | 2.0M | $52.6M | 2.4M | -367,509-15.40% | Reduce |
| BAKER BROS. ADVISORS LP |
| 0.28% | 0.25% | #34 | $56.6M | 2.0M | $44.3M | 2.0M | 00.00% | Unchanged |
| SR ONE CAPITAL MANAGEMENT, LP |
| 5.31% | 4.72% | #10 | $55.2M | 2.0M | $43.2M | 2.0M | 00.00% | Unchanged |
| Ikarian Capital, LLC |
| 3.66% | 2.64% | #15 | $34.5M | 1.2M | $32.6M | 1.5M | -251,300-17.00% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #96 | $33.0M | 1.2M | $33.3M | 1.5M | -338,019-22.36% | Reduce |
| Novo Holdings A/S |
| 1.8% | — | #22 | $31.0M | 1.1M | $0 | 0 | +1.1M | New Buy |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.01% | 0.01% | #57 | $30.1M | 1.1M | $23.3M | 1.1M | +10,009+0.95% | Add |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #60 | $27.2M | 968,234 | $12.6M | 572,129 | +396,105+69.23% | Add |
| UBS Group AG |
| <0.01% | 0.01% | #86 | $26.8M | 951,796 | $67.3M | 3.1M | -2.1M-68.84% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #122 | $26.4M | 969,617 | $17.4M | 861,575 | +108,042+12.54% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #129 | $25.9M | 921,211 | $15.7M | 712,608 | +208,603+29.27% | Add |
| GREAT POINT PARTNERS LLC |
| 4.55% | 4.33% | #13 | $24.1M | 856,061 | $18.9M | 856,061 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #111 | $23.4M | 831,897 | $15.8M | 718,040 | +113,857+15.86% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #103 | $20.4M | 723,849 | $12.4M | 563,522 | +160,327+28.45% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #95 | $19.7M | 700,134 | $14.0M | 635,389 | +64,745+10.19% | Add |
| Integral Health Asset Management, LLC |
| 0.78% | 0.84% | #28 | $19.7M | 700,000 | $17.6M | 800,000 | -100,000-12.50% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #67 | $18.6M | 660,142 | $13.4M | 606,284 | +53,858+8.88% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #82 | $17.2M | 612,010 | $11.6M | 527,305 | +84,705+16.06% | Add |
| Opaleye Management Inc. |
| 1.4% | 1.6% | #24 | $15.5M | 550,000 | $12.1M | 550,000 | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.29% | 0.24% | #33 | $15.4M | 548,163 | $12.1M | 548,163 | 00.00% | Unchanged |
| ROYCE & ASSOCIATES LP |
| 0.12% | 0.1% | #36 | $14.8M | 525,303 | $10.5M | 476,392 | +48,911+10.27% | Add |
| Woodline Partners LP |
| 0.04% | — | #45 | $13.7M | 486,052 | $0 | 0 | +486,052 | New Buy |
| Spruce Street Capital LP |
| 2.17% | 2.08% | #20 | $11.0M | 392,574 | $8.6M | 392,574 | 00.00% | Unchanged |
| CITIGROUP INC |
| <0.01% | <0.01% | #84 | $10.8M | 385,400 | $2.2M | 98,924 | +286,476+289.59% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #65 | $10.6M | 376,119 | $14.5M | 658,115 | -281,996-42.85% | Reduce |
| MARSHALL WACE, LLP |
| 0.01% | 0.03% | #64 | $10.4M | 368,014 | $25.8M | 1.2M | -804,735-68.62% | Reduce |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.13% | 0.12% | #35 | $9.8M | 347,138 | $9.3M | 423,231 | -76,093-17.98% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #156 | $9.0M | 321,163 | $1.3M | 332,406 | -11,243-3.38% | Reduce |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.04% | 0.07% | #46 | $9.0M | 320,861 | $16.5M | 749,099 | -428,238-57.17% | Reduce |
| Weiss Asset Management LP |
| 0.09% | 0.41% | #40 | $8.8M | 311,371 | $24.2M | 1.1M | -786,046-71.63% | Reduce |
| Artia Global Partners LP |
| 1.45% | 1.43% | #23 | $7.8M | 278,546 | $7.2M | 325,046 | -46,500-14.31% | Reduce |
| BARCLAYS PLC |
| <0.01% | <0.01% | #121 | $7.7M | 273,716 | $4.9M | 222,658 | +51,058+22.93% | Add |
