| RA CAPITAL MANAGEMENT, L.P. |
| 3.79% | 4.21% | #6 | $435.7M | 9.9M | $397.1M | 9.9M | 00.00% | Unchanged |
| TPG GP A, LLC |
| 5.71% | 7.08% | #4 | $285.7M | 6.5M | $260.4M | 6.5M | 00.00% | Unchanged |
| VIKING GLOBAL INVESTORS LP |
| 0.4% | 0.36% | #18 | $140.6M | 3.2M | $128.1M | 3.2M | 00.00% | Unchanged |
| Atlas Venture Life Science Advisors, LLC |
| 14.95% | 15.2% | #2 | $131.8M | 3.0M | $120.1M | 3.0M | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 2.12% | 2.81% | #8 | $112.4M | 2.6M | $141.5M | 3.5M | -974,825-27.61% | Reduce |
| Enavate Sciences GP, LLC |
| 31.56% | 28.26% | #1 | $109.0M | 2.5M | $99.3M | 2.5M | 00.00% | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.1% | 0.01% | #30 | $70.4M | 1.6M | $6.0M | 150,000 | +1.5M+966.67% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #87 | $64.9M | 1.5M | $52.0M | 1.3M | +178,902+13.81% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #62 | $64.1M | 1.5M | $53.7M | 1.5M | +25,494+1.74% | Add |
| JENNISON ASSOCIATES LLC |
| 0.03% | 0.04% | #37 | $51.6M | 1.2M | $58.2M | 1.5M | -279,087-19.23% | Reduce |
| CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #57 | $50.9M | 1.2M | $46.8M | 1.2M | -10,895-0.93% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #86 | $49.8M | 1.1M | $41.3M | 1.0M | +102,504+9.96% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #81 | $44.9M | 1.0M | $30.3M | 756,227 | +265,307+35.08% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.6% | 0.52% | #13 | $39.8M | 905,000 | $26.4M | 658,439 | +246,561+37.45% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.31% | 0.46% | #21 | $30.0M | 680,916 | $38.9M | 970,590 | -289,674-29.85% | Reduce |
| Siren, L.L.C. |
| 0.54% | 0.33% | #14 | $26.9M | 610,515 | $12.0M | 300,000 | +310,515+103.51% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #71 | $21.0M | 478,016 | $30.3M | 756,376 | -278,360-36.80% | Reduce |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.28% | 0.43% | #22 | $20.9M | 474,981 | $25.9M | 645,530 | -170,549-26.42% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #85 | $20.1M | 457,145 | $15.6M | 389,872 | +67,273+17.26% | Add |
| BAKER BROS. ADVISORS LP |
| 0.09% | 0.09% | #34 | $17.6M | 400,000 | $16.0M | 400,000 | 00.00% | Unchanged |
| Casdin Capital, LLC |
| 0.88% | — | #12 | $17.6M | 400,000 | $0 | 0 | +400,000 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #77 | $17.1M | 388,810 | $10.6M | 263,174 | +125,636+47.74% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.1% | 0.02% | #31 | $17.0M | 385,447 | $3.1M | 76,633 | +308,814+402.98% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #59 | $14.3M | 325,333 | $5.6M | 140,641 | +184,692+131.32% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #65 | $12.8M | 290,113 | $7.0M | 175,483 | +114,630+65.32% | Add |
| Aberdeen Group plc |
| 0.02% | 0.04% | #43 | $12.5M | 284,138 | $22.6M | 564,175 | -280,037-49.64% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #100 | $12.2M | 278,292 | $3.3M | 81,395 | +196,897+241.90% | Add |
| Candriam S.C.A. |
| 0.05% | — | #36 | $10.2M | 233,208 | $0 | 0 | +233,208 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #102 | $9.8M | 222,949 | $5.7M | 142,081 | +80,868+56.92% | Add |
| Kalehua Capital Management LLC |
| 6.21% | 5.59% | #3 | $8.7M | 197,072 | $7.9M | 197,072 | 00.00% | Unchanged |
| Longaeva Partners L.P. |
| 0.19% | 0.02% | #26 | $8.6M | 196,352 | $508,862 | 12,693 | +183,659+1,446.93% | Add |
| Artisan Partners Limited Partnership |
| 0.01% | — | #49 | $8.3M | 189,498 | $0 | 0 | +189,498 | New Buy |
| Ensign Peak Advisors, Inc |
| 0.01% | 0.02% | #48 | $8.1M | 184,532 | $10.2M | 255,636 | -71,104-27.81% | Reduce |
| Soleus Capital Management, L.P. |
| 0.27% | 0.48% | #23 | $7.8M | 177,687 | $11.8M | 293,500 | -115,813-39.46% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #89 | $6.8M | 154,476 | $4.7M | 116,776 | +37,700+32.28% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #110 | $6.6M | 151,047 | $671,636 | 22,837 | +128,210+561.41% | Add |
| Sofinnova Investments, Inc. |
| 0.33% | — | #20 | $6.4M | 144,432 | $0 | 0 | +144,432 | New Buy |
| Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #58 | $6.2M | 140,309 | $1.7M | 42,242 | +98,067+232.16% | Add |
| Alyeska Investment Group, L.P. |
| 0.02% | 0.02% | #45 | $6.0M | 136,222 | $5.5M | 136,222 | 00.00% | Unchanged |
| GordonMD Global Investments LP |
| 2.37% | 3.8% | #7 | $6.0M | 136,000 | $5.5M | 136,000 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #90 | $5.7M | 129,753 | $4.8M | 120,253 | +9,500+7.90% | Add |
| Sio Capital Management, LLC |
| 0.93% | 1.69% | #11 | $5.6M | 127,808 | $11.8M | 294,340 | -166,532-56.58% | Reduce |
| Ishara Investments LP |
| 3.91% | 1.87% | #5 | $5.4M | 123,000 | $2.0M | 49,200 | +73,800+150.00% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #84 | $5.3M | 121,442 | $4.5M | 112,175 | +9,267+8.26% | Add |
| Artia Global Partners LP |
| 0.97% | 0.96% | #10 | $5.3M | 119,741 | $4.8M | 119,741 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #95 | $5.1M | 116,206 | $5.9M | 147,641 | -31,435-21.29% | Reduce |
| First Turn Management, LLC |
| 0.52% | — | #15 | $4.9M | 110,493 | $0 | 0 | +110,493 | New Buy |
| CITIGROUP INC |
| <0.01% | <0.01% | #76 | $4.8M | 110,163 | $723,945 | 18,058 | +92,105+510.05% | Add |
| Ikarian Capital, LLC |
| 0.5% | — | #16 | $4.7M | 107,500 | $0 | 0 | +107,500 | New Buy |
| D. E. Shaw & Co., Inc. |
| <0.01% | — | #69 | $4.5M | 101,644 | $0 | 0 | +101,644 | New Buy |
